Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations

Inhibition of Janus kinases by tyrosine phosphorylation inhibitor, Tyrphostin AG-490

(2015) Sajid Rashid et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family

(2015) Jennifer Munkert et al.   Molecular Plant

Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers

(2015) J. Munkert et al.   PLANT BIOLOGY

The role of substrate binding pocket residues phenylalanine 176 and phenylalanine 196 onPseudomonassp. OX1 tolueneo-xylene monooxygenase activity and regiospecificity

(2014) Burcu Sönmez et al.   BIOTECHNOLOGY AND BIOENGINEERING

Conversion of Substrate Analogs Suggests a Michael Cyclization in Iridoid Biosynthesis

(2014) Stephanie Lindner et al.   CHEMISTRY & BIOLOGY

A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase

(2014) Markus A. Keller et al.   Nature Communications

Truncation of N-terminal regions of Digitalis lanata progesterone 5β-reductase alters catalytic efficiency and substrate preference

(2013) Kristin Rudolph et al.   BIOCHIMIE

Nicotinamide-Dependent Ene Reductases as Alternative Biocatalysts for the Reduction of Activated Alkenes

(2012) Katharina Durchschein et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

(2012) Fernando Geu-Flores et al.   NATURE

Vein Patterning 1-encoded progesterone 5β-reductase: Activity-guided improvement of catalytic efficiency

(2012) Peter Bauer et al.   PHYTOCHEMISTRY

Progesterone 5β-reductase of Erysimum crepidifolium: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant protein

(2011) Jennifer Munkert et al.   PHYTOCHEMISTRY

Displacement of disordered water molecules from hydrophobic pocket creates enthalpic signature: Binding of phosphonamidate to the S1'-pocket of thermolysin

(2010) L. Englert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Highly conserved progesterone 5β-reductase genes (P5βR) from 5β-cardenolide-free and 5β-cardenolide-producing angiosperms

(2010) Peter Bauer et al.   PHYTOCHEMISTRY

Recombinant Δ4,5-Steroid 5 β-Reductases as Biocatalysts for the Reduction of Activated CC-Double Bonds in Monocyclic and Acyclic Molecules

(2009) Edyta Burda et al.   ADVANCED SYNTHESIS & CATALYSIS

The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Δ4,5-steroid 5β-reductase activity in Arabidopsis thaliana L.

(2009) V. Herl et al.   BIOCHIMIE

Digitalis purpurea P5βR2, encoding steroid 5β-reductase, is a novel defense-related gene involved in cardenolide biosynthesis

(2009) Pedro Pérez-Bermúdez et al.   NEW PHYTOLOGIST

A structure-based mechanism for benzalacetone synthase from Rheum palmatum

(2009) H. Morita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of Human Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition†,‡

(2008) Frédérick Faucher et al.   BIOCHEMISTRY

Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB

(2008) J. A. Bohnert et al.   JOURNAL OF BACTERIOLOGY

Determination of Alkali and Halide Monovalent Ion Parameters for Use in Explicitly Solvated Biomolecular Simulations

(2008) In Suk Joung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH