Journal
BIOCONJUGATE CHEMISTRY
Volume 19, Issue 8, Pages 1510-1513Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc8001826
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Funding
- National Institutes of Health [GM51814, GM58025]
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A fluorescently labeled, persulfated molecular umbrella (1) has been synthesized from cholic acid, lysine, spermine, and Coumarin 343 and found capable of entering live HeLa cells. The distributions of 1 throughout the cytoplasm and the nucleus were diffuse and punctate, respectively. This finding, together with its ability to cross liposomal membranes by passive diffusion, suggests that passive diffusion plays a significant role in the ability of I to enter cells. The fact that I is concentrated at the nucleus raises the possibility that molecular umbrellas of this type could be used for the nuclear targeting of drugs.
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