Article
Multidisciplinary Sciences
Masataka Umeda, Nobuya Yoshida, Ryo Hisada, Catalina Burbano, Seo Yeon K. Orite, Michihito Kono, Vasileios C. Kyttaris, Suzanne Krishfield, Caroline A. Owen, George C. Tsokos
Summary: ADAM9 proteinase plays a role in Th17 cell differentiation by promoting the activation of transforming growth factor beta 1. Adam9-deficient mice show reduced autoimmune symptoms, and ADAM9 gene deletion attenuates the ability of CD4(+) T cells from lupus patients to differentiate into Th17 cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Hung-Chih Lo, Wei-Jyun Hua, Hsin Yeh, Zhi-Hu Lin, Li-Chen Huang, Yi -Ru Ciou, Runcheng Ruan, Kai-Fan Lin, Ai -Jung Tseng, Alexander T. H. Wu, Wei-Hung Hsu, Chi -Hong Chao, Tung-Yi Lin
Summary: This study demonstrates that GMI protein inhibits lung cancer metastasis by suppressing cell migration and disrupting cell adhesion. GMI also induces degradation of integrins and increases expression of epithelial markers, leading to reduced pulmonary lesions in mice.
Article
Oncology
Tadakazu Ao, Satsuki Mochizuki, Yoshiki Kajiwara, Keisuke Yonemura, Takehiro Shiraishi, Ken Nagata, Eiji Shinto, Koichi Okamoto, Ines P. Nearchou, Hideyuki Shimazaki, Yoji Kishi, Yasunori Okada, Hideki Ueno
Summary: The tumor microenvironment, specifically the desmoplastic reaction (DR) composed of cancer-associated fibroblasts (CAFs), plays a crucial role in cancer aggressiveness. The study found that patients with immature-type DR have the worst relapse-free survival compared to other types. CAFs from the immature-type DR promote CRC cell proliferation and migration through the secretion of ADAM9s, leading to tumor growth and dissemination.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Briana E. Heinly, Christa N. Grant
Summary: Neuroblastoma is a biologically heterogeneous tumor derived from neural crest cells, and its treatment remains challenging. The expression of cell adhesion molecules in neuroblastoma is closely associated with clinical prognosis, and targeted therapies against cell adhesion molecules may represent an innovative treatment strategy in the future.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Cong Wang, Jing Dong, Jinru Sun, Shu Huang, Feifei Wu, Xinyu Zhang, Defang Pang, Yuan Fu, Longxuan Li
Summary: The study investigated the role of lncRNA XIST in cerebral ischemic stroke (CIS) and found that it regulates angiogenesis and alleviates cerebral vascular injury following CIS through modulation of the miR-92a/Itgα5 or KLF4 axis. This suggests that lncRNA XIST could be a potential target for the prevention and treatment of CIS.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Developmental Biology
Naoya Yamaguchi, Holger Knaut
Summary: Cell-extracellular matrix interactions are essential for cell anchoring and migration, with focal adhesions (FAs) playing a key role. However, the role of FAs in vivo is still not well understood.
Article
Multidisciplinary Sciences
Li Tang, Chengming Guo, Xu Li, Bo Zhang, Liuye Huang
Summary: TAF15 is significantly upregulated in gastric cancer tissues and cell lines, and promotes cell proliferation, migration, and invasion in gastric cancer via the RAF1/MEK/ERK signaling pathway. This suggests that TAF15 may serve as a potential molecular diagnostic marker or therapeutic target for gastric cancer.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Kazunori Mori, Masato Higurashi, Fumihiro Ishikawa, Motoko Shibanuma
Summary: This study showed that non-malignant mammary epithelial cells lose reattachment ability before undergoing cell death upon detachment, while breast cancer cells retain integrin levels and efficiently reattach to substrata. The sustained levels of beta 4 integrin, mediated by Rac1, were critical for reattachment ability and lung metastasis of breast cancer cells. High expression of ITGB4 and RAC1 was associated with poor prognosis in patients with breast cancer, suggesting them as potential therapeutic targets to prevent cancer cells from colonizing secondary organs during metastasis.
Article
Oncology
Giulia Spennati, Lisa F. Horowitz, David J. McGarry, Dominika A. Rudzka, Garett Armstrong, Michael F. Olson, Albert Folch, Huabing Yin
Summary: Metastasis is the primary cause of cancer patient mortality, and studying this process using organotypic liver and brain slices shows promise in closely replicating the tumour microenvironment for in vitro testing. Different invasion patterns and behaviors were observed in the breast cancer cells within the brain and liver slices, with variations in cell stiffness and adhesion forces influencing invasiveness. Inhibition of the Ras/MAPK/ERK pathway resulted in reduced invasiveness, highlighting the potential of organotypic tissue slices to better mimic in vivo conditions during cancer cell metastasis compared to traditional in vitro models.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Anatomy & Morphology
Margarita Lamprou, Marina Koutsioumpa, Angelos Kaspiris, Katerina Zompra, Theodoros Tselios, Evangelia Papadimitriou
Summary: Pleiotrophin (PTN) is a growth factor that plays an important role in prostate cancer growth and angiogenesis. This study suggests that PTN mediates the adhesion of prostate cancer cells to osteoblasts through its interaction with nucleolin (NCL). The findings provide insights into the mechanisms of prostate cancer bone metastasis and offer potential targets for therapeutic development.
Article
Multidisciplinary Sciences
Jianhua Qu, Biao Zheng, Kenoki Ohuchida, Haimin Feng, Stephen Jun Fei Chong, Xianbin Zhang, Rui Liang, Zhong Liu, Kengo Shirahane, Kazuhiro Mizumoto, Peng Gong, Masafumi Nakamura
Summary: This study found that PIK3CB is involved in PAAD metastasis and may serve as a potential therapeutic target for PAAD treatment. PIK3CB depletion significantly reduced PAAD metastasis potential by suppressing cell adhesion to collagen I in PAAD cells.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cell Biology
Mahbube Jafari, Nasibeh Rahimi, Mohammad-Saeid Jami, Morteza Hashemzadeh Chaleshtori, Fatemeh Elahian, Seyed Abbas Mirzaei
Summary: The study revealed that the elevated level of the NAGA gene in cancer cells has effects on drug resistance, cell apoptosis, and migration. Downregulation of the NAGA gene enhanced late apoptosis and decreased migration ability in cancer cells.
CELL BIOLOGY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Tatiane Senna Bialves, Claudio L. Q. Bastos, Marcos Freitas Cordeiro, Robert Tew Boyle
Summary: Despite advances in melanoma treatment, there are still challenges. Snake venom proteins/peptides show potential for binding and inhibiting melanoma cell proliferation. Combining these compounds with current therapies could lead to more effective treatments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Aibin Liu, Huayan Xie, Ronggang Li, Liangliang Ren, Baishuang Yang, Longxia Dai, Wenjie Lu, Baoyi Liu, Dong Ren, Xin Zhang, Qiong Chen, Yanming Huang, Ke Shi
Summary: ZIC2 was found to be upregulated in NSCLC tissues and high expression of ZIC2 correlated with worse overall and progression-free survival in NSCLC patients. Silencing ZIC2 inhibited tumorigenesis and reduced anoikis resistance in NSCLC cells. Further investigation revealed that silencing ZIC2 transcriptionally inhibited Src expression and inactivated steroid receptor coactivator/focal adhesion kinase signaling, thereby attenuating anoikis resistance in NSCLC cells.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Cell Biology
Sophie Ayama-Canden, Rodolfo Tondo, Martha Liliana Pineros Leyton, Noelle Ninane, Catherine Demazy, Marc Dieu, Antoine Fattaccioli, Aude Sauvage, Tijani Tabarrant, Stephane Lucas, Davide Bonifazi, Carine Michiels
Summary: Metastasis is the leading cause of mortality in breast cancer, especially in triple negative breast cancer. The extracellular matrix, specifically the IGDQ motif in fibronectin, plays a significant role in regulating cell migration before metastasis formation. SRSF6 is identified as a potential master regulator of cell migration and integrin trafficking, with Indacaterol showing potential as a therapy to prevent cell migration and reduce metastasis formation in breast cancer.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Geriatrics & Gerontology
Izabela Pereira Vatanabe, Renata Valle Pedroso, Ramon Handerson Gomes Teles, Julio Cesar Ribeiro, Patricia Regina Manzine, Henrique Pott-Junior, Marcia Regina Cominetti
Summary: This is the first systematic review and meta-analysis on cognitive frailty, which identified a significant association between older age and a history of falls in cross-sectional studies and showed a significant increase in mortality and dementia risk for those with cognitive frailty in longitudinal studies. It highlights the clinical importance of identifying cognitive frailty in vulnerable groups for prevention and management.
AGING & MENTAL HEALTH
(2022)
Article
Behavioral Sciences
Renata Valle Pedroso, Francisco Jose Fraga, Carla Manuela Crispim Nascimento, Henrique Pott-Junior, Marcia Regina Cominetti
Summary: This study investigated the impact of APOE genotype on cortical activity and found that the APOEε4 allele negatively influenced P300 latency and amplitude in both healthy older adults and individuals with Alzheimer's disease.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Gregory F. Grawe, Katia M. Oliveira, Celisnolia M. Leite, Tamires D. de Oliveira, Joao Honorato, Antonio G. Ferreira, Eduardo E. Castellano, Marcia R. Cominetti, Rodrigo S. Correa, Alzir A. Batista
Summary: Three new ruthenium(ii) diphosphine complexes containing an acylthiourea ligand were synthesized and characterized, showing cytotoxicity against lung cancer cell lines. These complexes can act as cytotoxic agents for lung cancer treatment.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Celisnolia M. Leite, Joao Honorato, Ana Carolina B. M. Martin, Rafael G. Silveira, Felippe M. Colombari, Jessica C. Amaral, Analu R. Costa, Marcia R. Cominetti, Ana M. Plutin, Debora de Aguiar, Boniek G. Vaz, Alzir A. Batista
Summary: The study synthesized and characterized six copper(I) complexes, which exhibited cytotoxicity towards three tumor cell lines, with one complex showing significant effects on the cytoskeleton and induction of apoptosis in TNBC cells.
INORGANIC CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Fabio Fernandes Neves, Henrique Pott-Junior, Sigrid de Sousa Santos, Marcia Regina Cominetti, Caio Cesar de Melo Freire, Anderson Ferreira da Cunha, Alceu Afonso Jordao
Summary: This study aimed to evaluate the relationship between vitamin D deficiency and mortality in patients with COVID-19. The results showed that patients with deficient plasma 25(OH)D levels had a higher mortality rate, which remained a significant predictor even after adjusting for potential confounders.
CLINICAL NUTRITION ESPEN
(2022)
Article
Biochemistry & Molecular Biology
Tamires D. de Oliveira, Gabriel H. Ribeiro, Joao Honorato, Celisnolia M. Leite, Aline Caroline da S. Santos, Elis D. Silva, Valeria Rego A. Pereira, Ana M. Plutin, Marcia R. Cominetti, Eduardo E. Castellano, Alzir A. Batista
Summary: In this study, group 10 transition metal complexes bearing dppe and acylthiourea ligands were evaluated for their cytotoxic and antiparasitic activities. The complexes showed higher cytotoxicity against breast cancer cells and exhibited good anti-parasitic activity against Trypanosom Cruzi and Leishmania sp. parasites.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kelli C. Micocci, Ariele C. Moreira, Amanda D. Sanchez, Jessica L. Pettinatti, Marina C. Rocha, Bruna S. Dionizio, Katia C. S. Correa, Iran Malavazi, Felipe C. Wouters, Odair C. Bueno, Dulce Helena F. Souza
Summary: This study describes the first obtaining of a recombinant chitinase from ants and the characterization of its insecticidal and antifungal activities.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Chemistry, Medicinal
Angelica E. Graminha, Cecilia Popolin, Joao Honorato de Araujo-Neto, Rodrigo S. Correa, Katia M. de Oliveira, Luani R. Godoy, Legna Colina Vegas, Javier Ellena, Alzir A. Batista, Marcia R. Cominetti
Summary: In this work, new ruthenium compounds with specific ligands were synthesized and characterized. The properties of these compounds in different solvents were studied, and their cytotoxicity against breast tumor cells and non-tumor cell lines was evaluated. One specific compound showed excellent selectivity towards the MDA-MB-231 cell line and induced apoptosis through the intrinsic pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Katia Celina Santos Correa, Ariele Cristina Moreira, Amr Galal Abd El-Raheem Ibrahim, Hugo Cesar Ramos de Jesus, Kelli Cristina Micocci, Flavio Vinicius Crizostomo Kock, Odair C. Bueno, Tiago Venancio, Flavio Henrique-Silva, Dulce Helena F. Souza
Summary: Cysteine peptidases play important roles in insect development and could be potential targets for insect control. In this study, a cysteine cathepsin L was characterized from the leaf-cutting ant, Atta sexdens. The protein, AsCathL, showed expression throughout insect development and in all body parts of the adult ant, indicating its function as a lysosomal cathepsin. Phylogenetic analysis revealed its similarity to other predicted cathepsins in ants. The enzyme exhibited hydrolytic activity at acidic pH and was inhibited by recombinant sugarcane cystatins. This study provides valuable insights into the cysteine peptidases of leaf-cutting ants and may contribute to future research on ant cathepsins.
PROTEIN EXPRESSION AND PURIFICATION
(2023)
Review
Psychiatry
Robert Whelan, Florentine M. Barbey, Marcia R. Cominetti, Claire M. Gillan, Anna M. Rosicka
Summary: Effective strategies for early detection of cognitive decline would provide individual and societal benefits, but the current methods are invasive or time-consuming. This article describes scalable and non-invasive strategies, such as blood sample analysis and smartphone measurements, for detecting the earliest markers of cognitive decline. However, there are technical and societal challenges that need to be addressed.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Marcia Regina Cominetti, Henrique Pott, Roman Romero-Ortuno, Raquel Gutierrez Zuniga
Summary: This study aimed to evaluate the impact of age-related hearing loss (ARHL) on cognitive decline in older adults. The results revealed a significant association between ARHL and cognitive decline, highlighting the importance of timely intervention. Additionally, the use of hearing aids was found to reduce the risk of cognitive decline.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yasmim G. Goncalves, Amanda B. Becceneri, Angelica E. Graminha, Victor M. Miranda, Rafaella R. Rios, Francisco Rinaldi-Neto, Monica S. Costa, Ana C. R. Goncalves, Victor M. Deflon, Kelly A. G. Yoneyama, Pedro I. S. Maia, Eduardo F. Franca, Marcia R. Cominetti, Roberto S. Silva, Gustavo Von Poelhsitz
Summary: This article describes the synthesis, physicochemical characterization, and in vitro antitumor assays of four novel ruthenium(II) complexes. The results demonstrate that these complexes have potential in vitro antitumor activity and contribute to further studies in medicinal inorganic chemistry.
DALTON TRANSACTIONS
(2023)
Article
Audiology & Speech-Language Pathology
Ruana Danieli da Silva Campos, Marisa Silvana Zazzetta, Fabiana de Souza Orlandi, Sofia Cristina Iost Pavarini, Marcia Regina Cominetti, Ariene Angelini dos Santos-Orlandi, Isabela Thais Machado de Jesus, Grace Angelica de Oliveira Gomes, Aline Cristina Martins Gratao, Leticia Pimenta Costa-Guarisco
Summary: The purpose of this study was to verify the relationship between hearing handicap and frailty in community-dwelling older adults. The results showed that there was a positive correlation between hearing handicap and frailty. This suggests that hearing handicap may be a potential risk factor for frailty.
Article
Veterinary Sciences
Silvia A. Teixeira, Mayara de Cassia Luzzi, Ana Carolina Baptista Moreno Martin, Terence Teixeira Duarte, Monica de Oliveira Leal, Gustavo Ramos Teixeira, Monise Tadin Reis, Carlos Roberto Almeida Junior, Karina Santos, Matias Eliseo Melendez, Diego da Cunha Silveira Alves da Silva, Priscila Neves Bernecule, Higor Vinicius Lourenco Firmino, Ana Laura Vieira Alves, Denise Peixoto Guimaraes, Joao Vitor Borduqui, Ana Carolina Laus, Bruna Minniti Mancano, Rui Manuel Reis
Summary: This study presents a unique animal facility in Brazil dedicated to cancer research, which has established various cancer models including conventional mouse models, genetically modified mouse models, and patient-derived xenograft models. These models have helped enhance our understanding of cancer biology and identify potential therapeutic targets for personalized therapy.
VETERINARY SCIENCES
(2022)
Meeting Abstract
Oncology
Ana Carolina Baptista Moreno Martin, Terence Duarte, Gustavo Teixeira, Renato Jose Da Silva Oliveira, Bruna Mancano, Carlos Almeida Junior, Rui Reis, Silvia Teixeira
PEDIATRIC BLOOD & CANCER
(2022)
Article
Biochemistry & Molecular Biology
Siva Santhiya Arul, Brinda Balakrishnan, Savithri S. Handanahal, Sangita Venkataraman
Summary: Viral nanoparticles are self-assembling delivery systems used for vaccines and therapeutic agents. They have improved biocompatibility and are widely used in various biomedical applications. However, large-scale production of VNPs still faces challenges.
Article
Biochemistry & Molecular Biology
Wisely Chua, Carl O. Marsh, Si En Poh, Winston LC. Koh, Melody Li Ying Lee, Li Fang Koh, Xin-Zi Emily Tang, Peter See, Zheng Ser, Shi Mei Wang, Radoslaw M. Sobota, Thomas L. Dawson Jr, Yik Weng Yew, Steven Thng, Anthony J. O'Donoghue, Hazel H. Oon, John E. Common, Hao Li
Summary: In this study, the gene expression of enzymes secreted by Malassezia globosa in the skin was investigated using targeted RNA sequencing. The study found that the expression of these enzymes is regulated by the fungus's environment and differs significantly from healthy skin sites. Additionally, a pseudoprotease MGL_3331 was identified to elicit an immune reaction in patients with atopic dermatitis. This highlights the importance of studying fungal proteins in physiologically relevant environments and their role in host immunity.
Article
Biochemistry & Molecular Biology
Belisa Parmeggiani, Marian Flores Signori, Cristiane Cecatto, Marina Rocha Frusciante, Manuela Bianchin Marcuzzo, Debora Guerini Souza, Rafael Teixeira Ribeiro, Bianca Seminotti, Diogo Onofre Gomes de Souza, Cesar Augusto Joa o Ribeiro, Moacir Wajner, Guilhian Leipnitz
Summary: Non ketotic hyperglycinemia (NKH) is a disorder caused by mutations in the genes encoding glycine cleavage system proteins, leading to severe neurodegeneration and white matter alterations. The study found that glycine affects myelin structure, glutamatergic system, and induces oxidative stress in neonatal rats and MO3.13 oligodendroglial cells.
Review
Biochemistry & Molecular Biology
Marie Rose Ndella Thiaw, Pascal Gantet
Summary: Mini zinc fingers play important roles in plant development, including control of cell division and expansion, meristem state transition, and growth and organ development. They have diverse modes of action, such as direct gene activation, interaction with specific transcription factors, and aggregation of protein complexes for chromatin remodeling. Further research is needed to explore their wider range of biological functions and their involvement in biotic and abiotic stress responses.
Article
Biochemistry & Molecular Biology
Shao-Jui Lai, Takahiro Kameda, Maasa Morita, Yuka Yamagata, Kaoruko Nishizaka, Yuna Horiuchi, Yukihiro Kobayashi, Yoko Usami, Jun-Jen Liu, Takeshi Kasama, Minoru Tozuka, Ryunosuke Ohkawa
Summary: In this study, the co-modification and impact of chymase and MPO on HDL were investigated. Sequential treatment with MPO and chymase generated two novel apoA-I fragments from HDL, one of which has a specific immunological property and can be used to predict patients with normal HDL-C levels and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Xiao-Mi Sun, Asami Yoshida, Takuya Ishii, Yan-Rong Jiang, Yi-Li Gao, Mikinori Ueno, Katsuya Hirasaka, Kiyoshi Osatomi
Summary: This study found that infection with the causative bacteria of edwardsiellosis, Edwardsiella tarda NUF251, leads to the production of superoxide radicals, causing oxidative stress. The research on the Jfsod1 gene suggests that the transcription factor NF-IL6 plays a significant role in upregulating the transcriptional activity of the gene in response to oxidative stress induced by NUF251 infection.
Article
Biochemistry & Molecular Biology
Shane M. Carey, Sean P. Kearns, Matthew E. Millington, Gregory S. Buechner, Beda E. Alvarez Jr, Leily Daneshian, Brendan Abiskaroon, Maksymilian Chruszcz, Edward L. D'Antonio
Summary: The importance of F337 in TcGlcK was investigated using the hole mutagenesis approach, revealing its key interactions with aromatic tail groups in inhibitor molecules. Mutants retaining activity and structural similarity were obtained, suggesting the possibility of TcHxK existing as a monomer lacking the F337 residue. Similar D-glucosamine inhibitors may bind less strongly to TcHxK due to the absence of van der Waals contacts from residue side chains.
Article
Biochemistry & Molecular Biology
Catia Barria, Diogo Athayde, Guillem Hernandez, Leonor Fonseca, Jorge Casinhas, Tiago N. Cordeiro, Margarida Archer, Cecilia M. Arraiano, Jose A. Brito, Rute G. Matos
Summary: Ribonucleases play a crucial role in RNA regulation by processing, degrading, and quality controlling cellular transcripts. Campylobacter jejuni, the main cause of human gastroenteritis, relies on the exoribonuclease PNPase (CjPNP) for low-temperature survival, virulence factor synthesis, and swimming, cell adhesion/invasion, and chick colonization abilities. The crystallographic structure of CjPNP, along with SAXS analysis, confirms its trimeric arrangement and provides insight into domain arrangement and flexibility. Mutations in highly conserved residues reveal unexpected RNA degradation activity even under conditions favoring polymerization. These findings have significant implications for the development of strategies to combat C. jejuni infections.
Article
Biochemistry & Molecular Biology
Elvira R. Shaykhutdinova, Maria S. Severyukhina, Inna V. Kholoshenko, Elena A. Gondarenko, Irina V. Shelukhina, Elena V. Kryukova, Alina M. Ismailova, Elena S. Sadovnikova, Igor A. Dyachenko, Arkady N. Murashev, Victor I. Tsetlin, Yuri N. Utkin
Summary: Evidence suggests that activating nicotinic acetylcholine receptors (nAChRs) can reduce cardiac injury caused by ischemia and reperfusion. In this study, the expression of a4, a6, and a132 nAChR subunits in the rat heart's left ventricle was demonstrated. The nAChR agonists cytisine and varenicline, commonly used for nicotine addiction treatment, were found to significantly reduce myocardial ischemia-reperfusion injury, with varenicline showing greater protection. The presence of a4132, a7, and/or a6132-containing receptors suggests that the protective effect of varenicline may be mediated by these subunits. These findings indicate a potential new use for cytisine and varenicline as cardioprotective agents.
Article
Biochemistry & Molecular Biology
Xinhai Xiong, Wenjie Chen, Cheng Chen, Qi Wu, Chaopeng He
Summary: This article summarizes the important roles of Cx43 in disease development from the perspective of subcellular localization and provides new ideas for Cx43 as a therapeutic target and the search for related pathological mechanisms.
Article
Biochemistry & Molecular Biology
Veronica Bastos, Simone Pascoal, Kamila Lopes, Marcia Mortari, Helena Oliveira
Summary: Cancer, especially melanoma, is a major global health problem due to its metastatic capacity, treatment resistance, and high mortality rates. The Chartergellus-CP1 peptide isolated from Chartergellus communis wasp venom showed selective cytotoxicity towards melanoma cell lines, inducing apoptosis, cell cycle impairment, and intracellular ROS increase.
Article
Biochemistry & Molecular Biology
Charlotte Claeyssen, Nathan Bulangalire, Bruno Bastide, Onnik Agbulut, Caroline Cieniewski-Bernard
Summary: Maintenance of striated muscle tissue relies on a dynamic network of protein-protein interactions. Desmin intermediate filaments play a crucial role in heart and skeletal muscle by maintaining cell structure and contributing to various cellular processes. The assembly of desmin intermediate filaments requires aB-crystallin, which is involved in multiple cellular functions.
Article
Biochemistry & Molecular Biology
Dhritiman Dey, Adhiraj Dasgupta, Dipanjan Ghosh, Oindrila Bhattacharjee, Abhrajyoti Ghosh, Ayae Honda, Dhrubajyoti Chattopadhyay
Summary: This study successfully identified host factors that interact with Chandipura Virus (CHPV) and play a critical role in infection, including A2M, LRP1, and GRP78. Knocking out A2M has a severe effect on viral infection, indicating the potential role of these host proteins in viral entry into host cells.
Article
Biochemistry & Molecular Biology
Anna Dotsenko, Igor Sinelnikov, Aleksandra Rozhkova, Ivan Zorov, Arkady Sinitsyn
Summary: Xylanases play important roles in various industrial applications, such as feed additives, pulp and paper bleaching, and the production of bread, food, and drinks. Xylanases from the GH10 family show high thermostability and resistance to protein inhibitors, making them promising candidates for these processes. This study successfully improved the thermostability and enzymatic activity of GH10 xylanase, which could enhance its effectiveness as a feed additive and during pulp and paper bleaching.
Article
Biochemistry & Molecular Biology
M. Jaquet, M. Bengue, K. Lambert, G. Carnac, D. Misse, C. Bisbal
Summary: Changes to our environment have led to the emergence of human pathogens such as chikungunya virus, which is now a major public health concern. In this study, the interconnection between skeletal muscle cells metabolism, their differentiation stage, and the infectivity of chikungunya virus was investigated. The results showed that chikungunya virus infectivity is dependent on cell differentiation and metabolism and that the virus interferes with cellular metabolism.
