Review
Biochemistry & Molecular Biology
Asma Rafiq, Sabreena Aashaq, Iqra Jan, Mushtaq A. Beigh
Summary: Sine Oculis Homeobox 1 (SIX1) is a vital member of the homeobox transcription factor family, playing crucial roles in organismal development and differentiation. Its aberrant expression has been linked to hearing impairment, renal anomalies, and tumorigenesis, highlighting its importance in various pathological conditions. As a transcription factor, SIX1 primarily regulates cellular functions by controlling the expression of different proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Kay Zin Kyaw, Woong Sub Byun, Yern-Hyerk Shin, Thanh-Hau Huynh, Ji Yun Lee, Eun Seo Bae, Hyen Joo Park, Dong-Chan Oh, Sang Kook Lee
Summary: Piceamycin (1), a macrocyclic lactam isolated from the silkworm's gut, has been found to possess antibacterial activity. This study investigates the potential anticancer activity of 1 and its underlying mechanisms in colorectal cancer (CRC) cells. The results show that 1 inhibits CRC cell growth by upregulating NDRG1, inducing cell cycle arrest and apoptosis, and inhibiting cell migration. The disruption of the interaction between NDRG1 and c-Myc is also observed. This suggests that 1 may serve as a potential candidate for CRC treatment by regulating NDRG1-mediated functionality.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Oncology
Jeeshan Jiffry, Thongthai Thavornwatanayong, Devika Rao, Elisha J. Fogel, Durvanand Saytoo, Rishika Nahata, Hillary Guzik, Imran Chaudhary, Titto Augustine, Sanjay Goel, Radhashree Maitra
Summary: The study revealed that Pelareorep can enhance its propagation and oncolytic effect in colorectal cancer cells by regulating autophagy-related genes and proteins.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jiawei Sun, Zizhen Zhang, Jingyu Chen, Meng Xue, Xia Pan
Summary: High expression of ELTD1 is correlated with lymph node metastasis and poor outcomes in colorectal cancer, promoting invasion and metastasis of CRC both in vitro and in vivo. Additionally, ELTD1 accelerates MMP2 transcriptional activity, potentially serving as a novel target for CRC metastasis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tamuro Hayama, Kotaro Hama, Tsuyoshi Ozawa, Yuko Fujiwara, Keijiro Nozawa, Keiji Matsuda, Kazuaki Yokoyama, Yojiro Hashiguchi, Hiroki Ochiai, Takeyuki Misawa, Takeo Fukagawa
Summary: This study explores the association between sphingolipid metabolism, genetic variations, and clinicopathological factors in colorectal cancer (CRC). By examining the expression levels of genes related to sphingolipid metabolism, the researchers found that CERS4 expression was significantly reduced in CRC with KRAS gene mutation, and high CERS4 expression was more common in colorectal cancer patients with vascular invasion.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Chih-Jie Shen, Ren-Hao Chan, Bo-Wen Lin, Nien-Chi Li, Ying-Hsuan Huang, Wen-Chang Chang, Ben-Kuen Chen
Summary: This study found that IL-8 and the activation of KRAS affect ROS production and metastasis in hyperlipidemia-associated CRC, providing potentially new treatment options for this type of CRC.
Article
Biochemistry & Molecular Biology
Huashan Liu, Zhenxing Liang, Chi Zhou, Ziwei Zeng, Fengwei Wang, Tuo Hu, Xiaowen He, Xiaojian Wu, Xianrui Wu, Ping Lan
Summary: This study reveals a cell-extrinsic role of KRAS in modulating the tumor microenvironment by reprogramming tumor-associated macrophages, promoting tumor progression and inducing resistance to cetuximab therapy. Mechanistically, mutant KRAS stabilizes HIF-1 alpha to drive the production of CSF2 and lactate in tumor cells, enhancing HIF-1 alpha stabilization and contributing to a permissive microenvironment for tumor malignancy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Biochemistry & Molecular Biology
You-Take Oh, Shi-Yong Sun
Summary: The involvement of the TRAIL/death receptor signaling pathway in the regulation of cancer invasion and metastasis is complex, with both positive and negative roles reported. The underlying molecular mechanisms are even more complicated. This review focuses on discussing the current understanding of how TRAIL/death receptor-mediated signaling regulates cancer cell invasion and metastasis.
Article
Oncology
Patricia Dias Carvalho, Flavia Martins, Susana Mendonca, Andreia Ribeiro, Ana Luisa Machado, Joana Carvalho, Maria Jose Oliveira, Sergia Velho
Summary: This study reveals the role of mutant KRAS in modulating cell fate through autonomous and nonautonomous signaling mechanisms in colorectal cancer cells. Mutant KRAS autonomously controls processes such as proliferation and cell-cell aggregation, while cancer cell invasion depends on the cooperation between fibroblast-derived HGF and mutant KRAS regulation of C-MET expression.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Junfeng Qiu, Mingzhou Li, Cailin Su, Yihao Liang, Ruizhang Ou, Xiaoning Chen, Chengmei Huang, Yaxin Zhang, Yaping Ye, Wenting Liao, Chao Zhang
Summary: This study found that in colorectal cancer (CRC), the expression of FOXS1 is upregulated and is positively correlated with poor survival. FOXS1 promotes malignant behavior of CRC cells, including proliferation, invasion, and angiogenesis, both in vitro and in vivo. Mechanistically, FOXS1 upregulates the transcriptional level of CXCL8 to regulate tumor growth and metastasis. These findings suggest that the FOXS1/CXCL8 axis may serve as a potential therapeutic target for the treatment of metastatic CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaohui Zhang, Tingyu Li, Ya-Nan Han, Minghui Ge, Pei Wang, Lina Sun, Hao Liu, Tianyu Cao, Yongzhan Nie, Daiming Fan, Hao Guo, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu
Summary: In this study, we identified a novel mechanism by which miR-125b enhances metastasis in CRC by targeting CFTR and CGN, promoting EMT and uPA expression and secretion, and enhancing RhoA/ROCK signaling pathway. These findings suggest miR-125b as a key functional molecule in CRC and a promising biomarker for the diagnosis and treatment of CRC.
Article
Oncology
Yunzhi Dang, Jiao Yu, Shuhong Zhao, Ximing Cao, Qing Wang
Summary: This study reveals that elevated expression of HOXA7 is associated with metastasis and poor prognosis in KRAS mutant colorectal cancer (CRC) patients. HOXA7 overexpression enhances the metastatic ability of KRAS mutant cells and promotes the infiltration of myeloid-derived suppressor cells (MDSCs). Furthermore, blocking MDSC infiltration can effectively suppress the metastasis of KRAS mutant CRC. Therefore, interrupting the HOXA7-mediated loop may provide a promising strategy for the treatment of this disease.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Shuyun Wang, Limin Nie, Yuxiao Song, Fang Zhang, Xiaozheng Chen, Wenjing Shi, Zijiang Yang, Yuping Sun, Qi Dang, Aiqin Gao
Summary: The study found that NRTN is enriched in colorectal cancer cells and predicts poor patient outcomes. Upregulated NRTN enhances cancer cell motility and angiogenesis, promoting tumor invasion and metastasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Cell Biology
Loretta Laszlo, Anita Kurilla, Tamas Takacs, Gyongyi Kudlik, Kitti Koprivanacz, Laszlo Buday, Virag Vas
Summary: This review focuses on the special role of the most common mutated isoform of RAS, KRAS, in colorectal cancer (CRC), including its effects on cell signalling, research models, and processes related to CRC development. The article attempts to cover the diverse effects of KRAS mutations on age-related CRC development, as well as the driving forces behind the rising incidence of CRC in young adults.
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Oncology
Thomas T. Vellinga, Tijana Borovski, Vincent C. J. de Boer, Szabolcs Fatrai, Susanne van Schelven, Kari Trumpi, Andre Verheem, Nikol Snoeren, Benjamin L. Emmink, Jan Koster, Inne H. M. Borel Rinkes, Onno Kranenburg
CLINICAL CANCER RESEARCH
(2015)
Article
Gastroenterology & Hepatology
Szabolcs Fatrai, Susanne J. van Schelven, Inge Ubink, Klaas M. Govaert, Danielle Raats, Jan Koster, Andre Verheem, Inne H. M. Borel Rinkes, Onno Kranenburg
Editorial Material
Oncology
Onno Kranenburg
Article
Biochemistry & Molecular Biology
Kari Trumpi, David A. Egan, Thomas T. Vellinga, Inne H. M. Borel Rinkes, Onno Kranenburg
Article
Gastroenterology & Hepatology
Yara Backes, Tom C. J. Seerden, Rosanne S. F. E. van Gestel, Onno Kranenburg, Inge Ubink, Raymond M. Schiffelers, Demian van Straten, Malu S. van der Capellen, Simone van de Weerd, Wendy W. J. de Leng, Peter D. Siersema, G. Johan A. Offerhaus, Folkert H. Morsink, Winesh Ramphal, Jochiim Terhaar Sive Droste, Anja U. G. van Lent, Joost M. J. Geesing, Frank P. Vleggaar, Sjoerd G. Elias, Miangela M. Lacle, Leon M. G. Moons
Review
Oncology
Emerens Wensink, Marinde Bond, Emre Kucukkose, Anne May, Geraldine Vink, Miriam Koopman, Onno Kranenburg, Jeanine Roodhart
Summary: The article summarizes the differences in treatment efficacy of different types of chemotherapy and monoclonal antibodies in dMMR mCRC patients, while also providing specific recommendations to accelerate research in this area.
CANCER TREATMENT REVIEWS
(2021)
Article
Geriatrics & Gerontology
Liza A. Wijler, Danielle A. E. Raats, Sjoerd G. Elias, Francina J. Dijk, Hanil Quirindongo, Anne M. May, Matthew J. W. Furber, Bram Dorresteijn, Miriam van Dijk, Onno Kranenburg
Summary: The study found that specialized nutritional support can improve muscle function and reduce systemic inflammation in cancer patients undergoing chemotherapy, without affecting the efficacy of chemotherapy. This provides a new potential avenue for maintaining overall well-being during chemotherapy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Review
Cell Biology
Stijn Wenmaekers, Bastiaan J. Viergever, Gunjan Kumar, Onno Kranenburg, Peter C. Black, Mads Daugaard, Richard P. Meijer
Summary: HUWE1 is postulated as a therapeutic response modulator that may affect platinum-DNA adducts and replication forks interaction to regulate the cytotoxic response to platinum drugs, targeting components of the DNA damage response to alter cellular sensitivity and resistance to platins. Further research on the relationship between HUWE1 and platinum drugs could provide new mechanistic insights into therapy resistance, potentially serving as a clinical biomarker for personalized cancer treatment strategies to enhance patient outcomes.
Article
Oncology
Susanna Poghosyan, Nicola Frenkel, Aristeidis Lentzas, Jamila Laoukili, Inne Borel Rinkes, Onno Kranenburg, Jeroen Hagendoorn
Summary: This study investigates the role of Nrp2 in colorectal cancer (CRC) progression. Nrp2 expression is associated with aggressive CRC and poor prognosis. Using murine CRC tumor-derived organoids, the researchers demonstrate that Nrp2 depletion leads to a change in phenotype, MET, and a dependence on IR signaling and autophagy. The study highlights the complex interaction between Nrp2 and alternative pro-survival mechanisms in aggressive CRC.
Article
Oncology
Dieuwke L. Marvin, Li You, Laura Bornes, Maarten van Dinther, Niek Peters, Hao Dang, Sarah K. Hakuno, Marten Hornsveld, Onno Kranenburg, Jacco van Rheenen, Jos H. T. Rohling, Miao-Ping Chien, Peter ten Dijke, Laila Ritsma
Summary: This study developed a dynamic TGF-beta/SMAD3 transcriptional fluorescent reporter to monitor the kinetics of TGF-beta/SMAD3 signaling. The reporter showed specificity and sensitivity in both in vitro and in vivo systems, and observed heterogeneity in cellular response to TGF-beta challenge.
Article
Oncology
Karen Bolhuis, G. Emerens Wensink, Marloes A. G. Elferink, Marinde J. G. Bond, Willemieke P. M. Dijksterhuis, Remond J. A. Fijneman, Onno W. Kranenburg, Inne H. M. Borel Rinkes, Miriam Koopman, Rutger-Jan Swijnenburg, Geraldine R. Vink, Jeroen Hagendoorn, Cornelis J. A. Punt, Sjoerd G. Elias, Jeanine M. L. Roodhart
Summary: Two clinical risk scores (CRSs) show predictive ability in a population-based cohort and predefined subgroups, but their limited discriminative ability hinders sufficient preoperative risk stratification for clinical decision-making.
Article
Multidisciplinary Sciences
Ewart Kuijk, Onno Kranenburg, Edwin Cuppen, Arne Van Hoeck
Summary: In this study, the impact of specific anti-cancer therapies on normal stem cells was investigated using organoids and whole-genome sequencing. The results demonstrate that certain anti-cancer drugs have a high mutational impact on cancer cells, but the mutational effect on normal cells remains unclear. The study also shows that chemotherapy drugs can effectively kill cancer cells, but they also increase the risk of developing second cancers by increasing the mutational burden on long-lived normal stem cells responsible for tissue renewal.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Esther Strating, Sjoerd Elias, Guus van Scharrenburg, Kaisa Luoto, Andre Verheem, Inne Borel Rinkes, Herman Steen, Onno Kranenburg
Summary: Colorectal cancer peritoneal metastases are difficult to detect using conventional imaging methods. This study explores the potential use of a PDGFRB-binding llama nanobody in detecting peritoneal metastases in mice. The results demonstrate the potential value of PDGFRB-targeted molecular imaging as a novel strategy for the non-invasive detection of peritoneal metastases in colorectal cancer.
Article
Cell Biology
Jamila Laoukili, Susanne van Schelven, Emre Kucukkose, Andre Verheem, Kaitlyn Goey, Miriam Koopman, Inne Borel Rinkes, Onno Kranenburg
Summary: The presence of BRAFV600E in colorectal cancer is associated with a higher chance of distant metastasis. Oxidative stress limits the metastatic capacity of disseminated tumor cells. This study using patient-derived organoids and tissue samples found that GCL-driven glutathione synthesis protects BRAFV600E-expressing tumors from oxidative stress during metastasis to the liver and the lungs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Esther Strating, Anne van de Loo, Sjoerd Elias, Marnix Lam, Onno Kranenburg
