Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1826, Issue 1, Pages 83-88Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2012.03.009
Keywords
Cancer; Cancer stem cell; Epigenetics; Differentiation; DNA methylation; Histone modifications
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Funding
- Association pour la Recherche sur le Cancer (ARC)
- la Ligue Nationale contre le Cancer
- grant Contrat Hospitaller de Recherche Translationnelle/CHRT, AVIESAN
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Epigenetic mechanisms are the key component of the dynamic transcriptional programming that occurs along the process of differentiation from normal stem cells to more specialized cells. In the development of cancer and according to the cancer stem cell model, aberrant epigenetic changes may ensure the property of cancer cells to switch cancer stem cell markers on and off in order to generate a heterogeneous population of cells. The tumour will then be composed of tumourigenic (cancer stem cells) and non-tumourigenic (the side population that constitutes the bulk of the tumour) cells. Characterizing epigenetic landscapes may thus help discriminate aberrant marks (good candidates for tumour detection) from cancer stem cell specific profiles. In this review, we will give some insights about what epigenetics can teach us about the origin of cancer stem cells. We will also discuss how identification of epigenetic reprogramming may help designing new drugs that will specifically target cancer stem cells. (C) 2012 Elsevier B.V. All rights reserved.
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