Article
Oncology
Julia Schnoell, Alexandra Scheiflinger, Sega Al-Gboore, Lorenz Kadletz-Wanke, Lukas Kenner, Gregor Heiduschka, Bernhard J. Jank
Summary: PSMD14 is commonly expressed in HNSCC patients and associated with advanced stages. High expression of PSMD14 mRNA is associated with a worse outcome, but this may be due to the association of PSMD14 with poor prognosticators.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Tobias Jagomast, Christian Idel, Luise Klapper, Patrick Kuppler, Anne Offermann, Eva Dreyer, Karl-Ludwig Bruchhage, Julika Ribbat-Idel, Sven Perner
Summary: This study investigated the clinical implications of CDK7 and pMED1 as potential biomarkers in head and neck squamous-cell cancer (HNSCC). The results showed that high levels of CDK7 were associated with lower survival rates and disease-free survival rates in HNSCC patients. Additionally, CDK7 expression was significantly elevated in immune cell infiltrated tumors. In vitro studies also demonstrated the potential of CDK7 inhibition as a therapeutic target.
Article
Dentistry, Oral Surgery & Medicine
Shijin Yu, Zongjun Ma, Tao Chen, Hong Wang, Qin Yao, Jin Li, Jie Cheng
Summary: The overexpression of ETV5 in head and neck squamous cell carcinoma is associated with aggressive features and reduced survival. Silencing ETV5 inhibits cell proliferation, migration, invasion, and induces apoptosis in vitro, and impairs tumor growth in vivo. ETV5 activates Slug transcription by binding its promoter region in HNSCC cells. Patients with ETV5highSlughigh have the worst survival outcomes.
Article
Oncology
William J. Benjamin, Kai Wang, Katherine Zarins, Emily Bellile, Freida Blostein, Ilona Argirion, Jeremy M. G. Taylor, Nisha J. D'Silva, Steven B. Chinn, Samara Rifkin, Maureen A. Sartor, Laura S. Rozek
Summary: Further research is needed to determine the impact of the oral microbiome on head and neck cancer, including its pathogenesis and outcomes. This study used 16s rRNA sequencing to analyze oral wash samples from 52 cases and 102 controls. Significant differences were found in the diversity and composition of the oral microbiome between the cases and controls. The presence of specific bacteria associated with periodontitis was more common in the cases, particularly among older patients and smokers.
Review
Biochemistry & Molecular Biology
Jacek Kabzinski, Monika Maczynska, Ireneusz Majsterek
Summary: This article discusses the potential use of microRNAs in the diagnosis of head and neck squamous cell carcinoma, highlighting their application in radiotherapy and immunotherapy, as well as addressing the challenges and future research directions in developing this promising technology.
Article
Immunology
Ling-ling Fu, Ming Yan, Min-Xian Ma, Yi Luo, Min Shao, Martin Gosau, Reinhard E. Friedrich, Tobias Vollkommer, Hong-chao Feng, Ralf Smeets
Summary: DCBLD1 is highly expressed in head and neck squamous cell carcinoma and is associated with poor patient prognosis. Further research is needed to investigate the underlying mechanism.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yaoting Zhang, Dongsheng Gu
Summary: This study found that pretreatment serum CRP level is associated with prognosis in patients with head and neck squamous cell carcinoma. Patients with high CRP level had worse survival outcomes, and CRP level is correlated with N1-3 stage and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biology
Delphine Avril, Jean-Philippe Foy, Jebrane Bouaoud, Vincent Gregoire, Pierre Saintigny
Summary: This article aims to review recently proposed biomarkers of radioresistance in HPV-negative HNSCC, which can be useful for stratifying tumor patients based on their predicted level of radioresistance.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Genetics & Heredity
Guangjin Chen, Jiwei Sun, Mengru Xie, Shaoling Yu, Qingming Tang, Lili Chen
Summary: High expression of PLAU in HNSCC is associated with poor prognosis, potentially impacting tumor progression by regulating cell adhesion, tissue migration, and the EMT process. Genes associated with PLAU are enriched in the EMT pathway. The bioinformatics analysis results were validated by in vivo and in vitro experiments.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Teresa Magnes, Sandro Wagner, Dominik Kiem, Lukas Weiss, Gabriel Rinnerthaler, Richard Greil, Thomas Melchardt
Summary: Head and neck squamous cell carcinoma is a heterogeneous disease arising from the mucosa of the upper aerodigestive tract, with only about one third of patients responding to checkpoint inhibitors. HPV status and combined positive score are the main biomarkers used in clinical practice, while other factors like tumor mutational burden and immune microenvironment show promise but require validation in prospective trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Article
Oncology
Kodai Nakamura, Naomi Hiyake, Tomofumi Hamada, Seiya Yokoyama, Kazuki Mori, Kouta Yamashiro, Mahiro Beppu, Yasuaki Sagara, Yoshiaki Sagara, Tsuyoshi Sugiura
Summary: The study identified a combination of six microRNAs that could accurately distinguish oral squamous cell carcinoma (OSCC) from the control group with a higher degree of accuracy compared to traditional serum tumor markers like SCC-Ag. This specific microRNA panel may serve as a novel candidate biomarker for oral cancer diagnosis.
Article
Medicine, General & Internal
Sora Kim, Gwang Ha Kim, Su Jin Park, Chae Hwa Kwon, I Hoseok, Moon Won Lee, Bong Eun Lee
Summary: Exosomal miRNAs have the potential to serve as biomarkers for esophageal squamous cell carcinoma (ESCC). This study identified specific exosomal miRNAs that were differentially expressed in ESCC, and validated their expression levels in the plasma of healthy controls and ESCC patients. The results showed that plasma exosomal miR-205-5p, miR-429, and miR-375-3p could be potential biomarkers for the diagnosis of ESCC.
JOURNAL OF CLINICAL MEDICINE
(2022)