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Medicine, Research & Experimental
Shahin Alizadeh-Fanalou, Mohsen Khosravi, Fatemeh Alian, Shirin Rokhsartalb-Azar, Ali Nazarizadeh, Maryam Karimi-Dehkordi, Forogh Mohammadi
Summary: miR-1297, a microRNA with dual functions, exhibits abnormal expression in various human cancers, acting as both a tumor suppressor and an oncogene.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Oncology
Suliman Khan, De-Yu Zhang, Ji-Yu Zhang, Mian Khizar Hayat, Jingli Ren, Safyan Nasir, Muhammad Fawad, Qian Bai
Summary: The expression and function of miRNAs play a crucial role in the development of HCC, affecting the biological behavior and clinical pathological features of liver cancer. Despite the unclear regulatory mechanisms, the potential of miRNA-based therapy for HCC warrants further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: KDM6B is a histone demethylase that can act as a tumor suppressor or an oncogene depending on the cellular context. This study summarizes the role of KDM6B in different oncological contexts, aiming to guide its clinical application.
Review
Oncology
Ludek Zavesky, Eva Jandakova, Vit Weinberger, Veronika Hanzikova, Ondrej Slanar, Milada Kohoutova
Summary: This article focuses on the differential expression of miRNAs in ascitic fluid and their potential roles in ovarian cancer. Let-7b and miR-143 act as tumor suppressors, while miR-26a-5p and miR-145-5p have both tumor-suppressing and oncogenic roles. The role of miR-95-3p is still debated, and conflicting findings have been reported for miR-182-5p and miR-200c-3p.
Article
Oncology
Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith, Mousa Alreshidi
Summary: This article reviews the spectrum of full-length BARD1 genes and their different isoforms, highlighting their anticipated associated risk. Additionally, the study emphasizes the role of BARD1 as an oncogene in breast cancer patients and its potential uses as a prognostic/diagnostic biomarker and therapeutic target for cancer susceptibility testing and treatment.
Review
Biochemistry & Molecular Biology
Surendra Kumar Sagar
Summary: This review focuses on the function of miR-106b and its downstream targets in cancer, providing insights into how miR-106b regulates cancer cell proliferation, migration, invasion, and metastasis by modulating tumor suppressor genes. The potential of miR-106b as a candidate for detection, diagnosis, and prognosis assessment in different cancer types is highlighted.
Article
Oncology
Antonio Ferreira, Jon C. Aster
Summary: Notch receptors participate in a conserved signaling pathway that has diverse effects on normal cells and is highly dependent on the cellular context and signaling dosage. Notch plays different roles in various types of cancers, acting as either an oncogene or a tumor suppressor and affecting tumor cells and stromal elements in multiple ways. This review provides an overview of the roles of Notch in cancer and discusses the challenges and potential approaches for clinical translation of Notch targeting agents.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Sarah M. Zimmerman, Phyo Nay Lin, George P. Souroullas
Summary: Mutations in chromatin modifying genes frequently occur in many kinds of cancer. Recent studies suggest that non-canonical functions of chromatin modifiers may be equally important and therapeutically actionable in different types of cancer. EZH2, a histone methyltransferase, demonstrates such a dual role in cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yichen Liu, Qiong Zhao, Tao Xi, Lufeng Zheng, Xiaoman Li
Summary: Metastasis refers to secondary tumor growth at a distant site from the primary tumor, which is closely linked to poor prognosis and mortality. miR-9 plays a dual role as a promoter or suppressor in cancer metastasis and is involved in coordinating multiple steps of the metastatic process. Studying the various mechanisms of miR-9 in regulating metastasis can facilitate further research and potentially inform clinical applications in the future.
Review
Oncology
Maria Victoria Castro, Pablo Lopez-Bergami
Summary: ROR1 and ROR2 are Wnt receptors, and they are associated with tumor progression. While ROR1 always promotes tumorigenesis, ROR2 has a complex role in different tumor types, either promoting or inhibiting tumor progression.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Oncology
Yafei Guo, Ping Lin, Yimin Hua, Chuan Wang
Summary: This review comprehensively overviews the structure, expression, and regulation of TRIM31 in cancer, discussing its dual role and influence on multiple cellular signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Review
Multidisciplinary Sciences
Fatemeh Tajik, Fatemeh Alian, Mohammad Yousefi, Ali Azadfallah, Aref Hoseini, Forogh Mohammadi, Maryam Karimi-Dehkordi, Shahin Alizadeh-Fanalou
Summary: miR-372 is a non-coding, single-stranded, endogenous RNA that regulates various biological processes by binding to 3'-UTR mRNAs and controlling gene expression at the post-transcriptional level. It has abnormal expression in many human malignancies, suggesting its role in carcinogenesis, where it can function both as an oncogene and a tumor suppressor.
Article
Genetics & Heredity
Gracjan Wator, Michal Seweryn, Przemyslaw Kapusta, Jaroslaw Swirta, Piotr Walega, Marcin Barczynski, Pawel P. Wolkow
Summary: This study used deep sequencing to investigate the heterogeneity of colorectal tumors, finding that the central and peripheral regions have different mutation frequencies and types. Somatic mutations were also identified in the healthy mucosa, suggesting clonal expansion of specific mutant alleles.
Review
Biology
Junaid Ali Shah, Saadullah Khattak, Mohd Ahmar Rauf, Yong Cai, Jingji Jin
Summary: miRNAs are small non-coding RNA transcripts that regulate gene expression in cells, including tumorigenesis. The miR-371-373 genes are found to be abnormally expressed in various cancers and may serve as molecular biomarkers for cancer diagnosis and prevention. Further studies linking miR-371-373 functions to tumorigenesis suggest their potential applications in cancer diagnosis and treatment.