Review
Chemistry, Analytical
Haojie Wang, Jin-Kun Guo, Han Mo, Xikang Zhou, Yiping Han
Summary: Structural health monitoring plays a crucial role in analyzing structural safety and has been successfully applied in various structures as a cost-effective management approach. This paper focuses on the basic principles, recent advances, and current status of fiber optic sensing technology and vision sensing technology, providing a comprehensive literature review. It introduces the advantages, limitations, and future directions of these two sensing technologies. The main contribution of this paper lies in the discussion on the integration of fiber optic sensing technology and vision sensing technology, demonstrating the feasibility and application potential of this integration through numerous examples. The conclusions highlight the effectiveness of this new integrated sensing technology in utilizing the advantages of both fields.
Article
Biophysics
A. M. Cusano, G. Quero, P. Vaiano, P. Cicatiello, M. Principe, A. Micco, M. Ruvo, M. Consales, A. Cusano
Summary: The study developed a label-free Lab-on-Fiber biosensing platform for highly sensitive detection of the major circulating form of vitamin D, 25(OH)D3. The platform combines plasmonic metasurfaces with optical fibers to enable direct and sensitive detection of 25(OH)D3 in clinically relevant ranges. This platform has the potential to be used in developing low-cost, fast, simple, and ready-to-use Point-of-Care diagnostic devices.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biochemical Research Methods
Jian-Zhang Pan, Chen Fan, Zhi-Qiang Zuo, Ying-Xin Yuan, Hui-Feng Wang, Zhi Dong, Qun Fang
Summary: This paper discusses the urgent needs, challenges, and future prospects of home laboratory (LAH), and proposes a possible roadmap for achieving the goal of LAH.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Biochemical Research Methods
Liuzheng Zheng, Nathan Hart, Yong Zeng
Summary: The field of micro-/nanorobotics has made significant progress and attracted interest from various research communities. Micro-/nanoscale robots offer unique advantages in chemical and biological sensing, making them a promising platform for future developments. This review provides an overview of the current state-of-the-art in micro-/nanorobotics, discusses the challenges faced, and presents the potential future applications of soft robotics in chemical and biological sensing.
Article
Chemistry, Analytical
F. Gambino, P. Cicatiello, M. Giaquinto, A. M. Cusano, A. Aliberti, A. Micco, A. Iele, E. Iaccarino, M. Ruvo, A. Ricciardi, A. Cusano
Summary: The development of photonic-based point of care devices requires the use of compact integrated biosensing platforms enabling reliable detection performances in small volumes. The Labon-Fiber technology aims to develop miniaturized, lightweight, and light-coupled optrodes with unprecedented detection performances associated with portable, plug-and-play, and user-friendly features. It represents a step forward in establishing LOF optrodes as sensing units for optical POC, further enlarging their applicability for the detection of a broad range of relevant biomarkers.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Chemistry, Analytical
Baptiste Moeglen Paget, Keertana Vinod Ram, Shuyan Zhang, Jayakumar Perumal, Sylvain Vedraine, Georges Humbert, Malini Olivo, U. S. Dinish
Summary: Photonic crystal fibers (PCFs) have unique light-guiding properties and have been widely studied for biomedical applications. PCF-based fluorescence sensors offer highly sensitive detection of biomolecules at low sample volumes. This review discusses recent advancements in fluorescence detection using different PCF configurations and compares them with conventional fluorescence methods. Prospective applications of PCF-based fluorescence sensing and their potential use as optofluidic biopsy needles for clinically relevant biomarker detection are also discussed.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Optics
Fei Liu, Wen Zhang, Xianzheng Lang, Xuecheng Liu, Ragini Singh, Guoru Li, Yiyan Xie, Bingyuan Zhang, Santosh Kumar
Summary: This paper presents the development of taper-in-taper fiber (TITF)-optical fiber-based sensors for chemical and biological detection. The TITF structure has a lower transmitted intensity than the traditional taper fiber structure, making it more sensitive to changes in the refractive index of the external environment. Experimental results demonstrate the chemical sensing capability of the TITF sensor with measurements of ethanol solutions. Additionally, the TITF sensor modified with ZnO-NPs shows high sensitivity for biological sensing, specifically for creatinine detection.
Article
Chemistry, Physical
Li Wang, Xiaoping Yue, Qizeng Sun, Linrong Zhang, Guozhang Ren, Gang Lu, Hai-Dong Yu, Wei Huang
Summary: Flexible organic electrochemical transistors (OECTs) have great potential in chemical and biological sensing due to their high sensitivity, biocompatibility, low cost, and light weight. This review summarizes recent progress in the fabrication and applications of flexible OECTs in sensing. Material selection, structural engineering, gate modification, and array-based sensors are discussed, highlighting the versatility and promising applications of OECT sensors.
Article
Chemistry, Analytical
Sarassunta Ucci, Sara Spaziani, Giuseppe Quero, Patrizio Vaiano, Maria Principe, Alberto Micco, Annamaria Sandomenico, Menotti Ruvo, Marco Consales, Andrea Cusano
Summary: Lab-on-fiber (LoF) optrodes offer advantages for real-time and label-free detection of biomarkers. Improving immobilization strategies using hinge carbohydrates significantly enhances the detection capability. By optimizing and validating the LoF platform, detection of the cancer-related biomarker Cripto-1 has been greatly improved.
Article
Engineering, Electrical & Electronic
Samith Hettiarachchi, Gehan Melroy, Amith Mudugamuwa, Peshan Sampath, Charith Premachandra, Ranjith Amarasinghe, Van Dau
Summary: This paper discusses the modeling, simulation, and experimentation of an active droplet generator used in LOC devices, focusing on the key factor of droplet generation. The study found that optimized droplet contraction width and flow rate ratios are crucial for effective droplet generation. Experimental results show that droplet formation occurs within a certain range of flow rate ratios, with droplet diameter decreasing as the flow rate ratio decreases.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Materials Science, Multidisciplinary
Armando Ricciardi, Michael Zimmer, Norbert Witz, Alberto Micco, Federica Piccirillo, Martino Giaquinto, Mathias Kaschel, Joachim Burghartz, Michael Jetter, Peter Michler, Andrea Cusano, Simone Luca Portalupi
Summary: This study presents a method to integrate optoelectronic chips onto optical fibers, achieving electrical contacting and light in-coupling. The successful integration of a laser onto a fiber opens new possibilities for the development of optoelectronic systems on fiber.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Analytical
Yu Wu, Jing Feng, Guang Hu, En Zhang, Huan-Huan Yu
Summary: This review discusses the recent advances in the design, fabrication, and applications of colorimetric sensors from 2015 to 2022. The classification and sensing mechanisms of colorimetric sensors are briefly described, and the design of colorimetric sensors based on several typical nanomaterials is discussed. The applications of colorimetric sensors in detecting various analytes are summarized, and the remaining challenges and future trends in the development of colorimetric sensors are also discussed.
Review
Biochemistry & Molecular Biology
Shiji Zhang, Danqing Liu, Guangtong Wang
Summary: Covalent organic frameworks (COFs) are highly ordered crystalline porous organic polymers with wide-ranging applications in fields such as gas storage, pollution removal, catalysis, and optoelectronics. The unique feature of COFs is their modifiable one-dimensional pores, which enable them to be used in chemical and biological sensing. This review provides an overview of the basic principles and diverse applications of COFs in sensing various substances, as well as discussing future trends and challenges in COFs-based chemical and biological sensing.
Review
Chemistry, Analytical
Gregorio Laucirica, Yamili Toum Terrones, Vanina Cayon, Maria Lorena Cortez, Maria Eugenia Toimil-Molares, Christina Trautmann, Waldemar Marmisolle, Omar Azzaroni
Summary: This article describes recent advances in solid-state nanochannel-based (bio)chemical sensors, including sensing principles, nanofabrication techniques and strategies for detecting specific targets. These solid-state nanochannels exhibit customized sensing functions due to their unique ion transport properties and integration of molecular recognition elements, showing great potential for various applications.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Stefano Manago, Giuseppe Quero, Gianluigi Zito, Gabriele Tullii, Francesco Galeotti, Marco Pisco, Anna Chiara De Luca, Andrea Cusano
Summary: This study investigated the influence of geometric configuration of SERS-active substrates on interaction with biological targets of various sizes. Results showed that SERS intensity was dependent on substrate geometry and its specific steric interfacing with biological targets.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Electrical & Electronic
Gaia Maria Berruti, Patrizio Vaiano, Alessandra Boniello, Sofia Principe, Giuseppe Quero, Giovanni Vito Persiano, Marco Consales, Andrea Cusano
Summary: In this study, we demonstrate the use of TAP LPG as a resonant core-to-cladding light coupling mechanism for the fabrication of a highly efficient heating device based on metallic coated FBG. Comparing with other coupling components, the TAP LPG-based device exhibits an actuation efficiency 2.5 times greater, making it the most effective and highly performing solution for energy transfer.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
L. Scherino, E. J. Schioppa, A. Arapova, G. M. Berruti, W. J. Bock, A. Boniello, A. Borriello, S. Campopiano, M. Consales, A. Cusano, F. Esposito, A. Iadicicco, S. Kachiguine, P. Mikulic, K. Nagai, T. Neves, P. Petagna, G. Quero, D. Robinson, A. Srivastava, P. Vaiano, N. Venturi, M. Zarrelli, A. Zotti, S. Zuppolini
Summary: This article presents the installation and operation of a prototype system of Fiber Optic Sensors (FOS) in the ATLAS experiment, aiming to evaluate its performance against radiation effects and assess its suitability for future collider experiments.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2022)
Article
Materials Science, Multidisciplinary
Armando Ricciardi, Michael Zimmer, Norbert Witz, Alberto Micco, Federica Piccirillo, Martino Giaquinto, Mathias Kaschel, Joachim Burghartz, Michael Jetter, Peter Michler, Andrea Cusano, Simone Luca Portalupi
Summary: This study presents a method to integrate optoelectronic chips onto optical fibers, achieving electrical contacting and light in-coupling. The successful integration of a laser onto a fiber opens new possibilities for the development of optoelectronic systems on fiber.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Analytical
Hiba Alhalaby, Maria Principe, Haitham Zaraket, Patrizio Vaiano, Anna Aliberti, Giuseppe Quero, Alessio Crescitelli, Valentina Di Meo, Emanuela Esposito, Marco Consales, Andrea Cusano
Summary: This paper presents the design and development of advanced LOF devices for labeled biosensing applications based on fluorescence enhancement. By integrating plasmonic and dielectric materials onto the tip of optical fibers, high-performance biological sensors can be realized, and the overall sensitivity can be further improved through fluorescence enhancement strategies.
Article
Chemistry, Analytical
Valentina Di Meo, Massimo Moccia, Gennaro Sanita, Alessio Crescitelli, Annalisa Lamberti, Vincenzo Galdi, Ivo Rendina, Emanuela Esposito
Summary: In this study, surface-enhanced infrared absorption spectroscopy was used to monitor the denaturation process of a surface-bound protein A monolayer. By comparing the reflectance spectra of different states, changes in the protein's vibration modes can be determined. It was found that hydrogen bond breaking during denaturation caused red-shifts in the principal vibration modes, creating barriers for refolding.
Article
Chemistry, Analytical
Sarassunta Ucci, Sara Spaziani, Giuseppe Quero, Patrizio Vaiano, Maria Principe, Alberto Micco, Annamaria Sandomenico, Menotti Ruvo, Marco Consales, Andrea Cusano
Summary: Lab-on-fiber (LoF) optrodes offer advantages for real-time and label-free detection of biomarkers. Improving immobilization strategies using hinge carbohydrates significantly enhances the detection capability. By optimizing and validating the LoF platform, detection of the cancer-related biomarker Cripto-1 has been greatly improved.
Article
Optics
Patrizio Vaiano, Giuseppe Quero, Francesco Fienga, Valentina Di Meo, Pierluigi Casolaro, Luigi Campajola, Giovanni Breglio, Alessio Crescitelli, Emanuela Esposito, Antonello Cutolo, Federico Ravotti, Salvatore Buontempo, Marco Consales, Andrea Cusano
Summary: Next generation High Energy Physics (HEP) accelerators require new devices and technologies capable of operating in extreme environments with ultra-high radiation doses. A Lab-On-Fiber (LOF) probe based on a metallo-dielectric nanostructured grating has been developed for real-time dose monitoring. Experimental results show that the LOF resonance wavelength and depth are dependent on the absorbed dose, and the main effect of radiation is the reduction of the PMMA thickness, which affects the resonance behavior.
OPTICS AND LASER TECHNOLOGY
(2023)
Review
Chemistry, Analytical
Aldo Minardo, Romeo Bernini, Gaia Maria Berruti, Giovanni Breglio, Francesco Antonio Bruno, Salvatore Buontempo, Stefania Campopiano, Ester Catalano, Marco Consales, Agnese Coscetta, Andrea Cusano, Maria Alessandra Cutolo, Pasquale Di Palma, Flavio Esposito, Francesco Fienga, Michele Giordano, Antonio Iele, Agostino Iadicicco, Andrea Irace, Mohammed Janneh, Armando Laudati, Marco Leone, Luca Maresca, Vincenzo Romano Marrazzo, Marco Pisco, Giuseppe Quero, Michele Riccio, Anubhav Srivastava, Patrizio Vaiano, Luigi Zeni, Antonello Cutolo
Summary: Our research group, made up of researchers from various universities in Campania, Italy, has been dedicated to studying photonic sensors for safety and security applications in healthcare, industry, and the environment for the past twenty years. This paper is the first in a series of three and it presents the main concepts of the technologies used in our photonic sensors and reviews our key findings in innovative applications for infrastructure and transportation monitoring.
Review
Chemistry, Analytical
Antonello Cutolo, Romeo Bernini, Gaia Maria Berruti, Giovanni Breglio, Francesco Antonio Bruno, Salvatore Buontempo, Ester Catalano, Marco Consales, Agnese Coscetta, Andrea Cusano, Maria Alessandra Cutolo, Pasquale Di Palma, Flavio Esposito, Francesco Fienga, Michele Giordano, Antonio Iele, Agostino Iadicicco, Andrea Irace, Mohammed Janneh, Armando Laudati, Marco Leone, Luca Maresca, Vincenzo Romano Marrazzo, Aldo Minardo, Marco Pisco, Giuseppe Quero, Michele Riccio, Anubhav Srivastava, Patrizio Vaiano, Luigi Zeni, Stefania Campopiano
Summary: In this paper, the employability of photonics technology in aerospace and submarine applications is explored. The main focus is on the use of optical fiber sensors for safety and security purposes. Recent in-field applications of optical fiber sensors in aircraft monitoring and underwater marine applications are presented and discussed.
Review
Chemistry, Analytical
Giovanni Breglio, Romeo Bernini, Gaia Maria Berruti, Francesco Antonio Bruno, Salvatore Buontempo, Stefania Campopiano, Ester Catalano, Marco Consales, Agnese Coscetta, Antonello Cutolo, Maria Alessandra Cutolo, Pasquale Di Palma, Flavio Esposito, Francesco Fienga, Michele Giordano, Antonio Iele, Agostino Iadicicco, Andrea Irace, Mohammed Janneh, Armando Laudati, Marco Leone, Luca Maresca, Vincenzo Romano Marrazzo, Aldo Minardo, Marco Pisco, Giuseppe Quero, Michele Riccio, Anubhav Srivastava, Patrizio Vaiano, Luigi Zeni, Andrea Cusano
Summary: This article focuses on environmental monitoring using photonic technologies, including high precision agriculture, soil water content measurement, landslide early warning, new generation seismic sensors, and optical fiber sensors for radiation environments.
Article
Biophysics
A. M. Cusano, G. Quero, P. Vaiano, P. Cicatiello, M. Principe, A. Micco, M. Ruvo, M. Consales, A. Cusano
Summary: The study developed a label-free Lab-on-Fiber biosensing platform for highly sensitive detection of the major circulating form of vitamin D, 25(OH)D3. The platform combines plasmonic metasurfaces with optical fibers to enable direct and sensitive detection of 25(OH)D3 in clinically relevant ranges. This platform has the potential to be used in developing low-cost, fast, simple, and ready-to-use Point-of-Care diagnostic devices.
BIOSENSORS & BIOELECTRONICS
(2023)