Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1843, Issue 11, Pages 2698-2704Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2014.08.001
Keywords
Focal CNA; Chromosomal aberrations; Driver genes; Oncogenes; Tumor suppressor genes
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Funding
- VUmc Cancer Center Amsterdam (VUmc-CCA)
- Center for Translational Molecular Medicine (CTMM)
- DeCoDe project [03O-101]
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The extent of focal chromosomal copy number aberrations (CNAs) in cancer has been uncovered through technical innovations, and this discovery has been critical for the identification of new cancer driver genes in genomics projects such as TCGA and ICGC. Unlike constitutive copy number variations (CNVs), focal CNAs are the result of many selection events during the evolution of cancer genomes. Therefore, it is possible that a single gene in a focal CNA gives the tumor a selective growth advantage. This concept has been instrumental in the discovery of new cancer driver genes. However, focal CNAs lack a consensus definition; therefore, we propose one based on pragmatic considerations. We also describe different strategies to identify focal CNAs and procedures to distinguish them from large CNAs and CNVs. (C) 2014 Elsevier B.V. All rights reserved.
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