Article
Biochemistry & Molecular Biology
Peiling Wang, Xiangmei Hua, Yang Sun, Hongyu Li, Yuge Han Bryner, Richard P. Hsung, Jun Dai
Summary: Recent studies have shown that Haspin, a protein kinase essential for mitosis, plays a crucial role in the interphase progression of cancer cells. Loss of Haspin results in cell cycle defects, prolonging S/G2 phase, leading to mitotic cell death or postmitotic G1 arrest. Additionally, Haspin deficiency induces p21 checkpoint protein expression and co-depletion with p21 or p53 can partially restore cell proliferation.
Article
Multidisciplinary Sciences
Yoshiko Oyama, Shogo Shigeta, Hideki Tokunaga, Keita Tsuji, Masumi Ishibashi, Yusuke Shibuya, Muneaki Shimada, Jun Yasuda, Nobuo Yaegashi
Summary: Platinum sensitivity is an important prognostic factor in ovarian cancer patients. CHD4, a core member of the nucleosome remodeling complex, has been found to regulate MDR1 expression in ovarian cancer, affecting platinum sensitivity. Overexpression of CHD4 is associated with platinum resistance and poor patient survival in ovarian cancer.
Article
Biochemistry & Molecular Biology
Zhiyuan Zhang, Qi Wu, Meimiao Fang, Yu Liu, Ji Jiang, Qingyang Feng, Ronggui Hu, Jianmin Xu
Summary: In this study, it was found that HERC3 controls colorectal cancer (CRC) proliferation and the cell cycle by ubiquitination degradation of RPL23A, and further modulates cell proliferation through the c-Myc/p21 axis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yu Liu, Risheng Huang, Deyao Xie, Xiaoming Lin, Liangcheng Zheng
Summary: ZNF674-AS1 expression is decreased in NSCLC compared to normal tissues, and its downregulation is significantly correlated with advanced TNM stage and decreased overall survival of NSCLC patients. ZNF674-AS1 inhibits NSCLC cell proliferation, colony formation, and tumorigenesis, accompanied by G0/G1 cell cycle arrest, through upregulation of p21 and downregulation of miR-423-3p. This study suggests the therapeutic potential of ZNF674-AS1 in NSCLC treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Alisha Shaikh, Austin A. Wesner, Mohanad Abuhattab, Raman G. Kutty, Priyatha Premnath
Summary: Cell cycle regulators have been found to prevent cancerogenesis by acting as inhibitors or activators, and they also play active roles in differentiation, apoptosis, senescence, and other cellular processes. Recent evidence suggests that they are involved in bone healing/development cascade. Our study showed that deletion of p21, a cell cycle regulator, at the G1/S transition, enhanced bone repair capacity after a burr-hole injury in mice. Similarly, another study demonstrated that inhibition of p27 can increase bone mineral density and bone formation. In this review, we provide a concise overview of cell cycle regulators in osteoblasts, osteoclasts, and chondrocytes during bone development and/or healing. Understanding the regulatory processes of cell cycle during bone healing and development is crucial for the development of novel therapies to improve bone healing in aged or osteoporotic fractures.
CELL AND BIOSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Review
Pharmacology & Pharmacy
Dharambir Kashyap, Vivek Kumar Garg, Elise N. Sandberg, Neelam Goel, Anupam Bishayee
Summary: Cancer, a disease of inappropriate cell proliferation, is closely linked to the cell cycle, with multiple genetic alterations leading to cancer development. Both oncogenes and tumor suppressor genes regulate the cell cycle and play key roles in breast cancer progression. These components are tightly controlled in normal breast epithelial cells, but following mitogenic stimuli, their deregulation promotes neoplastic transformation. Numerous clinical studies have revealed prognostic significance in screening for these components, impacting patient outcomes and treatment responses. The review aims to summarize the roles of oncogenic and tumor-suppressive components in breast cancer progression and prognosis.
Article
Environmental Sciences
Mingjun Sun, Jingwen Tan, Mengjie Wang, Weihua Wen, Yuefeng He
Summary: The study found that arsenic increased the expression of AS3MT in vivo and in vitro, directly acting on cells and affecting the progression of non-small cell lung cancer by regulating cell cycle genes.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cell Biology
Stephanie Chrysanthou, Julio C. Flores, Meelad M. Dawlaty
Summary: Tet1 plays a non-catalytic role in regulating cell cycle progression and proliferation in mouse embryonic stem cells, mainly by suppressing p21 to ensure a rapid G1-to-S progression.
Article
Biochemistry & Molecular Biology
Ann-Kathrin Schmidt, Karoline Pudelko, Jan-Eric Boekenkamp, Katharina Berger, Maik Kschischo, Holger Bastians
Summary: Whole chromosome instability is a hallmark of human cancer and can be induced by abnormal microtubule assembly rates during mitosis, triggering errors in chromosome segregation. Loss of tumor suppressor genes can lead to increased mitotic microtubule assembly rates and contribute to chromosome instability in cancer cells.
Article
Biochemistry & Molecular Biology
Haibo Zhang, Weiping Yao, Minjun Zhang, Yanwei Lu, Jianming Tang, Mingyun Jiang, Xiaozhou Mou, Guangxian You, Xiaodong Liang
Summary: The study showed that the TTK inhibitor can enhance the radiosensitivity of liver cancer cells by regulating cell cycle and centrosome abnormalities, leading to apoptosis and necrosis. The TTK inhibitor may be a potential radiosensitizer for patients with liver cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ali Ghorbani Ranjbary, Ali Bagherzadeh, Seyed Sina Sabbaghi, Arshida Faghihi, Delaram Nassaj Karimi, Shahryar Naji, Mohsen Kardani
Summary: CGA exhibits anticancer activity in colorectal cancer cells by regulating cell cycle and inducing apoptosis.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Cell Biology
Yixin Tong, Yuan Huang, Yuchao Zhang, Xiangtai Zeng, Mei Yan, Zhongsheng Xia, Dongming Lai
Summary: DPP3 plays an oncogene-like role in the development and progression of CRC by targeting CDK1, which is correlated with lymphatic metastasis, pathological stage, and number of positive lymph nodes. Downregulation of DPP3 inhibits cell proliferation, migration and promotes apoptosis by upregulating multiple apoptosis-related genes.
CELL DEATH & DISEASE
(2021)
Article
Biology
Levin Lataster, Hanna Mereth Huber, Christina Boettcher, Stefanie Foeller, Ralf Takors, Gerald Radziwill
Summary: The cell cycle includes four phases, and optogenetic methods can be used to control the function of p21. Stimulation with light can increase the number of cells arrested in the G1 phase, thereby increasing the production of biotherapeutic proteins.
Review
Cell Biology
Md Gulam Musawwir Khan, Yi Wang
Summary: This review summarizes the regulation of the cell cycle and cell-cycle-associated proteins by low-dose ionizing radiation (LDIR) and discusses the conceptual function and possible dichotomous role of p21(Waf1) in response to LDIR.
Article
Biotechnology & Applied Microbiology
Constanca Figueiredo, Marco Carvalho Oliveira, Chen Chen-Wacker, Katharina Jansson, Klaus Hoeffler, Yuliia Yuzefovych, Olena Pogozhykh, Zhu Jin, Mark Kuehnel, Danny Jonigk, Bettina Wiegmann, Wiebke Sommer, Axel Haverich, Gregor Warnecke, Rainer Blasczyk
HUMAN GENE THERAPY
(2019)
Article
Genetics & Heredity
Giovanna Cruz, Xiaorong Shao, Hong Quach, Diana Quach, Kimberly A. Ho, Kirsten Sterba, Janelle A. Noble, Nikolaos A. Patsopoulos, Michael P. Busch, Darrell J. Triulzi, Nektarios Ladas, Rainer Blasczyk, Wendy S. W. Wong, Benjamin D. Solomon, John E. Niederhuber, Lindsey A. Criswell, Lisa F. Barcellos
GENES AND IMMUNITY
(2020)
Article
Biochemistry & Molecular Biology
Damaris A. Schillingmann, Sebastian B. Riese, Vijith Vijayan, Sabine Tischer-Zimmermann, Helga Schmetzer, Britta Maecker-Kolhoff, Rainer Blasczyk, Stephan Immenschuh, Britta Eiz-Vesper
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Caroline Mangare, Sabine Tischer-Zimmermann, Sebastian B. Riese, Anna C. Dragon, Immo Prinz, Rainer Blasczyk, Britta Maecker-Kolhoff, Britta Eiz-Vesper
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Genetics & Heredity
F. Stieglitz, A. A. Celik, C. von Kaisenberg, M. A. Camps, R. Blasczyk, Christina Bade-Doeding
Review
Biochemistry & Molecular Biology
Trishna Manandhar, Gia-Gia T. Ho, Wiebke C. Pump, Rainer Blasczyk, Christina Bade-Doeding
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Cell Biology
Constanca Figueiredo, Felix Oldhafer, Eva-Maria Wittauer, Marco Carvalho-Oliveira, Ali Akhdar, Oliver Beetz, Chen Chen-Wacker, Yuliia Yuzefovych, Christine S. Falk, Rainer Blasczyk, Florian W. R. Vondran
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Immunology
Rebecca E. Schultze-Florey, Sabine Tischer-Zimmermann, Hans-Gert Heuft, Christoph Priesner, Britta Lamottke, Albert Heim, Martin Sauer, Karl-Walter Sykora, Rainer Blasczyk, Britta Eiz-Vesper, Britta Maecker-Kolhoff
TRANSPLANT INFECTIOUS DISEASE
(2020)
Article
Pharmacology & Pharmacy
Gwendolin S. Simper, Lareen S. Graeser, Alexander A. Celik, Joachim Kuhn, Heike Kunze-Schumacher, Gia-Gia T. Ho, Rainer Blasczyk, Andreas Pich, Christina Bade-Doeding
Article
Pediatrics
Fabio Ius, Carsten Mueller, Wiebke Sommer, Murielle Verboom, Michael Hallensleben, Jawad Salman, Thierry Siemeni, Christian Kuehn, Murat Avsar, Dmitry Bobylev, Reza Poyanmehr, Caroline Erdfelder, Dietmar Boethig, Julia Carlens, Lale Bayir, Gesine Hansen, Rainer Blasczyk, Christine Falk, Andreas Tecklenburg, Axel Haverich, Igor Tudorache, Nicolaus Schwerk, Gregor Warnecke
PEDIATRIC PULMONOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Gia-Gia T. Ho, Alexander A. Celik, Trevor Huyton, Wiebke Hiemisch, Rainer Blasczyk, Gwendolin S. Simper, Christina Bade-Doeding
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Denys Pogozhykh, Dorothee Eicke, Oleksandr Gryshkov, Willem E. Wolkers, Kai Schulze, Carlos A. Guzman, Rainer Blasczyk, Constanca Figueiredo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Eline Gall, Florian Stieglitz, Andreas Pich, Georg Martin Norbert Behrens, Joachim Kuhn, Rainer Blasczyk, Funmilola Josephine Haukamp, Christina Bade-Doeding
Summary: Type B adverse drug reactions pose a significant threat to patients due to their unpredictable occurrence. In the treatment of HIV-positive patients, a severe immune reaction known as Abacavir Hypersensitivity Syndrome (AHS) can arise, which is strongly correlated to a specific gene. However, not all patients carrying this gene are affected by the reaction, suggesting the involvement of other factors. By classifying patients based on their gene profile and analyzing the cellular proteome, potential biomarkers for predicting drug susceptibility have been identified.
Article
Biology
Miriam Laubert, Agnes Bonifacius, Anna Christina Dragon, Caroline Mangare, Rainer Blasczyk, Jochen Huehn, Britta Eiz-Vesper
Summary: This study investigates the impact of vitamin C on virus-specific T cells, showing that vitamin C can increase the activation state of these cells, especially in male donors and donors above 40 years of age. This suggests the potential application of vitamin C as an additional selection criterion and strategy to improve virus-specific T-cell therapy.
Article
Biochemistry & Molecular Biology
Gia-Gia T. Ho, Wiebke Hiemisch, Andreas Pich, Georg M. N. Behrens, Rainer Blasczyk, Christina Bade-Doeding
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)