Journal
ANALYST
Volume 140, Issue 5, Pages 1416-1420Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4an01675k
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2014R1A1A3051319]
- GRRC program of Gyeonggi province [GRRC Gachon 2014-A01]
- Public Welfare & Safety Research program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [NRF-2012M3A2A1051681]
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We introduce a new strategy for fabricating a seamless three-dimensional (3D) helical microreactor utilizing a silicone tube and a paraffin mold. With this method, various shapes and sizes of 3D helical microreactors were fabricated, and a complicated and laborious photolithographic process, or 3D printing, was eliminated. With dramatically enhanced portability at a significantly reduced fabrication cost, such a device can be considered to be the simplest microreactor, developed to date, for performing the flow-through polymerase chain reaction (PCR).
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