Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 20, Issue 11, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.20.11.116002
Keywords
photoacoustic; Bessel beam; Grueneisen relaxation; nonlinear microscopy
Funding
- National Institutes of Health [DP1 EB016986, R01 CA186567, R01 CA159959]
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The short focal depth of a Gaussian beam limits the volumetric imaging speed of optical resolution photoacoustic microscopy (OR-PAM). A Bessel beam, which is diffraction free, provides a long focal depth, but its side lobes deteriorate image quality when the Bessel beam is directly employed to excite photoacoustic (PA) signals in OR-PAM. We present a nonlinear approach based on the Grueneisen relaxation effect to suppress the side-lobe artifacts in PA imaging. This method extends the focal depth of OR-PAM and speeds up volumetric imaging. We experimentally demonstrated a 1-mm focal depth with a 7-mu m lateral resolution and volumetrically imaged a carbon fiber and red blood cell samples. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
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