Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1792, Issue 4, Pages 380-391Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2009.02.010
Keywords
Dog; Cat; Stem cell; Telomerase
Funding
- Biotechnology and Biological Sciences Research Council [BB/F008848/1] Funding Source: Medline
- BBSRC [BB/F008848/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F008848/1] Funding Source: researchfish
Ask authors/readers for more resources
The recently described cancer stem cell theory opens up many new challenges and opportunities to identify targets for therapeutic intervention. However, the majority of cancer related therapeutic studies rely upon rodent models of human cancer that rarely translate into clinical success in human patients. Naturally occurring cancers in dogs, cats and humans share biological features, including molecular targets, telomerase biology and turnout genetics. Studying cancer stem cell biology and telomere/telomerase dynamics in the cancer bearing pet population may offer the opportunity to develop a greater understanding of cancer biology in the natural setting and evaluate the development of novel therapies targeted at these systems. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
