Article
Biochemistry & Molecular Biology
Huili Yao, Anabel Soldano, Leo Fontenot, Fabrizio Donnarumma, Scott Lovell, Josephine R. Chandler, Mario Rivera
Summary: Bacteria cells have two types of iron storage proteins, and P. aeruginosa utilizes a single heterooligomeric Bfr assembled from FtnA and BfrB subunits for iron storage.
Article
Biochemistry & Molecular Biology
Jan Gombos, Lucia Balejcikova, Peter Kopcansky, Marianna Batkova, Katarina Siposova, Jozef Kovac, Kristina Zolochevska, Ivo Safarik, Alica Lokajova, Vasil M. Garamus, Dusan Dobrota, Oliver Strbak
Summary: This article investigates the destructive effect of ferritin derivatives on lysosome amyloid fibrils and the release of iron ions. The results suggest that ferritin derivatives have both therapeutic and adverse effects, which may play a significant role in future biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Spectroscopy
Leiliang He, Jingjing Wang, Zhenzhen Wan, Yamin Xiong, Jin Man, Ya Wang, Guojiang Mao, Fei Yu
Summary: An engineered self-assembled biomimetic-compartmented nanoprobe (APO@CDs) has been developed for in-situ imaging of iron storage/release from ferritin in cells. This nanoprobe showed higher sensitivity and specificity to ferrous ions (Fe3+), and reduced cytotoxicity. It provides a potential platform for the dynamic study of iron storage/release in the biomedical field.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Nutrition & Dietetics
Matthew W. W. Stefan, David M. M. Gundermann, Matthew H. H. Sharp, Brooke A. A. Jennings, Raad H. H. Gheith, Ryan P. P. Lowery, Tieraona LowDog, Somsuvra B. B. Ghatak, Jose Barbosa, Jacob M. M. Wilson
Summary: The study aims to evaluate the effectiveness of a low-dose liquid fermented iron-bisglycinate supplement in improving blood-iron status in premenopausal women with iron deficiency without anemia. The results show that the supplement can increase serum ferritin, total serum iron, and mean corpuscular volume without causing significant gastrointestinal distress.
Article
Food Science & Technology
Mingyang Sun, Hanhan Liu, Chen Xu, Zhenghui Jiang, Chenyan Lv
Summary: Protein-small molecule interactions in food can improve properties but also affect bioavailability of proteins. Beer-inspired protein-polyphenol interactions can inhibit iron release from ferritin, providing a novel method for controlling iron release.
Article
Physics, Applied
Michael G. Christiansen, Nima Mirkhani, William Hornslien, Simone Schuerle
Summary: Single domain magnetic nanoparticles are investigated as actuators in biological and chemical processes, and their localized effects may involve induced electric fields.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Chemistry, Applied
Rui Yang, Jing Tian, Yuqian Liu, Lei Zhu, Jixuan Sun, Demei Meng, Zhiwei Wang, Chengtao Wang, Zhongkai Zhou, Lingyun Chen
Summary: Chlorogenic acid can form complexes with Fe(III) and bind with ferritin through hydrogen bonds, promoting iron oxidation and release. This study elucidates interactions among multiple components in foodstuffs using a protein-metal-polyphenol model.
Article
Biochemistry & Molecular Biology
Aliaksandra A. Reutovich, Ayush K. Srivastava, Gideon L. Smith, Alexandre Foucher, Douglas M. Yates, Eric A. Stach, Georgia C. Papaefthymiou, Paolo Arosio, Fadi Bou-Abdallah
Summary: This study investigated the impact of phosphate on the kinetics, structure, and reactivity of ferritin iron cores. The results showed that phosphate significantly accelerated the oxidation and core formation of iron in ferritin, as well as influenced the size and morphology of the iron mineral. Additionally, phosphate promoted the mobilization of iron from ferritin. These findings have important implications for understanding the importance of ferritin iron management in vivo.
Article
Chemistry, Multidisciplinary
Zhiqiang Chen, Aijian Huang, Ke Yu, Tingting Cui, Zewen Zhuang, Shoujie Liu, Jianzhan Li, Renyong Tu, Kaian Sun, Xin Tan, Jiaqi Zhang, Di Liu, Yu Zhang, Peng Jiang, Yuan Pan, Chen Chen, Qing Peng, Yadong Li
Summary: Through a fast-pyrolyzing and controllable-activation strategy, an O-rich carbonaceous support and atomically dispersed FeN4 site with axial O coordination were constructed, achieving a wide potential range and high FECO. DFT calculations revealed that the superior performance originated from the axial O-coordination induced electronic localization enhancement, facilitating CO desorption and increasing the energy barrier for competitive hydrogen evolution reaction.
ENERGY & ENVIRONMENTAL SCIENCE
(2021)
Article
Cell Biology
Jiazhi Yi, Shuyun Wu, Siwei Tan, Yunfei Qin, Xing Wang, Jie Jiang, Huiling Liu, Bin Wu
Summary: The study found that BBR can alleviate mouse liver fibrosis and restore liver function, but Fer-1 treatment significantly diminishes the pharmacological effects of BBR. BBR induces HSC ferroptosis by affecting the autophagy-lysosome pathway and increasing ROS production in HSCs, thereby slowing down the progression of liver fibrosis.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Prashanth Kumar Koochana, Abhinav Mohanty, Akankshika Parida, Narmada Behera, Pabitra Mohan Behera, Anshuman Dixit, Rabindra K. Behera
Summary: The study demonstrates the reductive iron mobilization from ferritins using three flavin analogues, with riboflavin (RF) being the most effective in releasing iron. The generation of O-2(center dot-) during the reaction plays a significant role in the iron release process.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2021)
Article
Engineering, Environmental
Kaiyi Huang, Yang Yang, Hansha Lu, Shiwen Hu, Guojun Chen, Yanhong Du, Tongxu Liu, Xiaomin Li, Fangbai Li
Summary: This study investigates the transformation processes of nickel in paddy soils under anoxic and oxic conditions. The results show that under anoxic conditions, complexation with soil organic matter dominates nickel immobilization, while under oxic conditions, organic matter and Fe-Mn oxides contribute similarly to nickel release.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Food Science & Technology
Jiangnan Hu, Lina Shi, Lei Zhu, Xinmei Sha, Yue Li, Junrui Ma, Qing Zhang, Rui Yang
Summary: This study examined the effects of two phenolic acid analogs on the physicochemical properties of soybean ferritin. The results showed that the phenolic acid analogs formed complexes with Fe(III) and ferritin, which affected the ferritin structure to different extents. Caffeic acid and tanshinol facilitated iron oxidative deposition and release, with caffeic acid having a more pronounced effect. Caffeic acid also protected ferritin from degradation and exhibited higher Fe(II) chelating ability and hydroxyl radical scavenging ability compared to tanshinol.
Article
Biochemistry & Molecular Biology
Pilar C. Portela, Marta A. Silva, Liliana R. Teixeira, Carlos A. Salgueiro
Summary: Geobacter bacteria are capable of electron transfer for potential bioremediation or energy harvesting. The cytochrome PpcA plays a crucial role in bridging electron transfer, with unique redox properties due to specific amino acids, allowing for modulation of redox potential and potential engineering for bioelectrochemical applications.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ralph G. DePalma, Virginia W. Hayes, Timothy J. O'Leary
Summary: This report discusses the dual roles of serum ferritin as an indicator for iron status and inflammation. It highlights the positive associations between serum ferritin levels, inflammatory markers, and mortality rates. Lowering serum ferritin levels within a certain range may be beneficial for reducing cardiovascular mortality.
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)