Review
Immunology
Xueqi Wan, Huan Zhang, Jinfan Tian, Peng Hao, Libo Liu, Yuquan Zhou, Jing Zhang, Xiantao Song, Changjiang Ge
Summary: Atherosclerosis is a cardiovascular disease with unknown pathogenesis and treatment. The discovery of ferroptosis as a contributing factor in atherosclerosis provides a potential approach for targeted therapy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Medicine, General & Internal
Dandan Meng, Chengfeng Zhu, Ruixue Jia, Zongxin Li, Wantao Wang, Suhua Song
Summary: Ferroptosis is a novel form of cell death characterized by intracellular iron accumulation and lipid peroxidation. It involves a complex regulatory network of iron metabolism, lipid metabolism, amino acid metabolism, p53-related signaling, and Nrf2-related signaling factors. Recent studies have implicated ferroptosis in the pathology of neurological diseases, cancer, and ischemia-reperfusion injury. Notably, ferroptosis has been found to be closely related to the pathogenesis of COPD, indicating its potential as a therapeutic target for this chronic airway inflammatory disease.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jessica L. H. Walters, Amanda L. Anderson, Sarah J. Martins da Silva, R. John Aitken, Geoffry N. De Iuliis, Jessie M. Sutherland, Brett Nixon, Elizabeth G. Bromfield
Summary: Overproduction of reactive oxygen species resulting in lipid peroxidation and the production of cytotoxic reactive carbonyl species such as 4-hydroxynonenal is a prevalent cause of sperm dysfunction in male infertility patients. ALOX15 plays a key role in this pathway in human spermatozoa, with increased ALOX15 abundance leading to membrane lipid peroxidation and cellular dysfunction, ultimately contributing to male infertility.
Review
Cell Biology
Meng-Yi Luo, Jian-Hui Su, Shao-Xin Gong, Na Liang, Wen-Qian Huang, Wei Chen, Ai-Ping Wang, Ying Tian
Summary: The dynamic balance of cardiomyocytes and neurons is crucial for the normal functions of heart and brain. Excessive cell death in tissues can lead to Cardio-Cerebrovascular Diseases, and the regulation of cell death, including the iron-dependent ferroptosis, plays a critical role in promoting or alleviating these diseases. Inhibitors related to ferroptosis may have implications for the prevention and treatment of Cardio-Cerebrovascular Diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
David Soriano-Castell, Antonio Currais, Pamela Maher
Summary: Ferroptosis is a form of regulated cell death dependent on iron and lipid peroxidation. Various inhibitors have been tested to distinguish ferroptosis from other forms of cell death.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Suman Basak, Harshvardhan Ajay Khare, Paul J. Kempen, Nazila Kamaly, Kristoffer Almdal
Summary: Atherosclerosis, a leading cause of death worldwide, can be effectively treated using newly developed ROS-scavenging antioxidant nanoparticles. These nanoparticles, synthesized via reversible addition-fragmentation chain-transfer (RAFT) polymerization, act as a superoxide dismutase (SOD) mimetic agent. The nanoparticles are shown to be taken up by macrophages and exhibit cytocompatibility. Additionally, the nanoparticles have been demonstrated to inhibit foam cell formation in macrophages.
NANOSCALE ADVANCES
(2022)
Article
Medicine, Research & Experimental
Pakawit Lerksaipheng, Kittiphong Paiboonsukwong, Pimtip Sanvarinda, Rataya Leuchapudiporn, Ken-Ichi Yamada, Noppawan Phumala Morales
Summary: This study suggests that vascular complications in patients with beta-thalassemia are associated with oxidative modification of lipoproteins. The modification of lipid components may alter lipid peroxidation rate and products. Core lipids and cholesteryl esters levels determine the rate and total production of L center dot. Overall, lipoproteins in beta-thalassemia patients are more susceptible to lipid peroxidation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Nutrition & Dietetics
Xin-Fang Leong
Summary: Cardiovascular diseases like hypertension and atherosclerosis are common causes of death in developed and developing countries. Repeatedly heating dietary oils can lead to the production of toxic lipid oxidation products, impairing antioxidant capacity in the body and potentially leading to inflammation and oxidative stress. Understanding the pathways associated with lipid oxidation-derived aldehydes may help in developing therapeutic strategies for preventing inflammatory-related cardiovascular complications.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yunjia Li, Mengchen Qin, Weichao Zhong, Chang Liu, Guanghui Deng, Menghan Yang, Junjie Li, Haixin Ye, Hao Shi, Chaofeng Wu, Haiyan Lin, Yuyao Chen, Shaohui Huang, Chuying Zhou, Zhiping Lv, Lei Gao
Summary: The study indicates the important role of RAGE in alcoholic liver disease (ALD). Deficiency or inhibition of RAGE can alleviate hepatic inflammation and oxidative stress, as well as affect iron metabolism pathways, thereby improving liver injury.
Article
Pharmacology & Pharmacy
Xiaojiao Zhang, Tao Song, Mengnan Zhao, Xueshu Tao, Bohan Zhang, Cong Sun, Pinying Wang, Kunpeng Wang, Lin Zhao
Summary: Neuropathic pain is a chronic condition that often does not respond well to general analgesics and has a negative impact on patients' health and quality of life. A recent study found that SIRT2, by suppressing ferroptosis, has a neuroprotective effect. In a rat model of neuropathic pain, it was demonstrated that upregulating SIRT2 expression can alleviate mechanical allodynia, inhibit intracellular iron accumulation, reduce oxidant stress levels, and reverse the symptoms of chronic neuropathic pain.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Liyan Deng, Shasha He, Nuoqing Guo, Wen Tian, Weizhen Zhang, Lianxiang Luo
Summary: Inflammation is a defensive response to irritation and is involved in various diseases. Ferroptosis, a type of cell death regulated by multiple cellular metabolic pathways, has been found to be associated with inflammation. Targeting ferroptosis shows great prospects in preventing and treating inflammatory diseases.
INFLAMMATION RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Magnus Back
Summary: Cardiovascular outcome trials on omega-3 fatty acids have conflicting results, but suggest that eicosapentaenoic acid (EPA) has dose-dependent beneficial effects. Besides triglyceride lowering, EPA may have beneficial cardiovascular effects through different mechanisms. This review addresses the link between EPA and resolution of atherosclerotic inflammation.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Haider H. Dar, Karolina Mikulska- Ruminska, Yulia Y. Tyurina, Diane K. Luci, Adam Yasgar, Svetlana N. Samovich, Alexander A. Kapralov, Austin B. Souryavong, Vladimir A. Tyurin, Andrew A. Amoscato, Michael W. Epperly, Galina V. Shurin, Melissa Standley, Theodore R. Holman, Claudette M. St. Croix, Simon C. Watkins, Andrew P. VanDemark, Sandeep Rana, Alexey V. Zakharov, Anton Simeonov, Juan Marugan, Rama K. Mallampalli, Sally E. Wenzel, Joel S. Greenberger, Ganesha Rai, Huelya Bayir, Ivet Bahar, Valerian E. Kagan
Summary: Programmed ferroptotic death eliminates cells in all major organs and tissues through iron-catalyzed lipid peroxidation under inadequate control by thiols. Ferroptosis is associated with the development of chronic degenerative diseases and acute injuries in various organs, making it a potential target for therapeutic intervention. The study focuses on inhibiting the catalytic complex of 15-lipoxygenase (15LOX) and phosphatidylethanolamine (PE)-binding protein 1 (PEBP1), rather than 15LOX alone, as a strategy to discover antiferroptotic agents. The design and testing of a customized library of compounds led to the identification of two lead compounds, FerroLOXIN-1 and 2, which effectively suppress ferroptosis in vitro and in vivo by interacting with the 15LOX-2/PEBP1 complex.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Correction
Cell Biology
Anushka Katikaneni, Mark Jelcic, Gary F. Gerlach, Yanan Ma, Michael Overholtzer, Philipp Niethammer
Summary: A correction to this paper has been published.
NATURE CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thiliban Manivarma, Aleksandr A. Kapralov, Svetlana N. Samovich, Yulia Y. Tyurina, Vladimir A. Tyurin, Andrew P. Vandemark, Wieslaw Nowak, Huelya Bayir, Ivet Bahar, Valerian E. Kagan, Karolina Mikulska-Ruminska
Summary: This study investigates the molecular basis of pro-ferroptotic interactions between 15LOX-1 and PEBP1. The association of the complex with the membrane triggers a conformational change, facilitating substrate access to the catalytic site. Binding of SAPE promotes tight interactions and induces further conformational changes for the oxidation reaction. The PEBP1 P112E mutation is found to be significant in generating ferroptotic cell death signals.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Rocco Maurizio Zagari, Leonardo Henry Eusebi, Giuseppe Galloro, Stefano Rabitti, Matteo Neri, Luigi Pasquale, Franco Bazzoli
Summary: Practice patterns for the management of Barrett's esophagus among endoscopists in Italy vary, with differences in the use of the Prague classification, using the top of gastric folds as a landmark for the GEJ, and routine use of advanced endoscopy imaging. Attending training courses on BE improves adherence to guidelines.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Psychiatry
Chiara Conti, Ilenia Rosa, Luigia Zito, Laurino Grossi, Konstantinos Efthymakis, Matteo Neri, Piero Porcelli
Summary: This preliminary study suggests that patients with active inflammatory bowel disease tend to be more affected by the Covid-19 outbreak, showing higher psychological distress and somatization, as well as poorer disease-specific health-related quality of life. The quality of life of these patients seems to be more influenced by psychological and somatizing distressing symptoms than the pandemic-related living conditions.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Immunology
Alfredo Papa, Franco Scaldaferri, Lorenzo Maria Vetrone, Matteo Neri, Antonio Gasbarrini, Loris Riccardo Lopetuso
Summary: The severity of the COVID-19 pandemic has led to unprecedented efforts to develop vaccines against SARS-CoV-2, with the administration of vaccines starting in different regions worldwide. However, concerns about the safety and efficacy of the rapid vaccine development and distribution process have arisen, particularly for patients with chronic conditions or compromised immune systems. Strategies for achieving the highest vaccination rates in IBD patients are discussed, based on clinical experience and data from vaccinations against other infections.
Article
Gastroenterology & Hepatology
Gaetano Bergamaschi, Fabiana Castiglione, Renata D'Inca, Marco Astegiano, Walter Fries, Monica Milla, Carolina Ciacci, Fernando Rizzello, Simone Saibeni, Rachele Ciccocioppo, Ambrogio Orlando, Fabrizio Bossa, Mariabeatrice Principi, Piero Vernia, Chiara Ricci, Maria L. Scribano, Giorgia Bodini, Dario Mazzucco, Gabrio Bassotti, Gabriele Riegler, Andrea Buda, Matteo Neri, Flavio Caprioli, Fabio Monica, Aldo Manca, Erica Villa, Gionata Fiorino, Michele Comberlato, Nicola Aronico, Cristina Della Corte, Roberta Caccaro, Paolo Gionchetti, Paolo Giuffrida, Paola Iovino, Marco Lenti, Caterina Mengoli, Lucienne Pellegrini, Alberto Pieraccini, Davide Ribaldone, Anna Testa, Cristina Ubezio, Anna Viola, Maurizio Vecchi, Catherine Klersy, Antonio Di Sabatino
Summary: The prevalence of anemia in Italian IBD patients is lower than previously reported, with the majority being caused by iron deficiency and leading to fatigue and decreased quality of life. However, a large proportion of patients with iron and/or vitamin deficiencies remain untreated.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Konstantinos Efthymakis, Matteo Neri
Summary: Zinc L-carnosine is a pharmaceutical compound that has direct mucosal cytoprotective and anti-inflammatory effects. It works through antioxidative effects, cytokine modulation, and membrane stabilization. It has shown beneficial effects in various types of mucosal damage and intestinal damage. It has been widely used for the treatment of peptic ulcers and mucositis induced by chemoradiotherapy. It also has potential therapeutic applications in ulcerative colitis, iatrogenic ulcers, hemorrhoidal disease, and impaired intestinal permeability.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Pier Alberto Testoni, Chiara Notaristefano, Marco Soncini, Cesare Hassan, Fabio Monica, Franco Radaelli, Omero Triossi, Luigi Pasquale, Matteo Neri, Renato Cannizzaro, Gioacchino Leandro
Summary: This study assessed the current status of colonoscopy procedures in Italian centers and found that high colonoscopy quality standards have been achieved by the Italian hospitals involved. Quality improvement initiatives, repeated module-based colonoscopy training, and the activation of colorectal cancer screening programs in Italy have had a significant impact on quality colonoscopy metrics.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Nutrition & Dietetics
Konstantinos Efthymakis, Giuseppina Bologna, Pasquale Simeone, Laura Pierdomenico, Giulia Catitti, Simone Vespa, Angelo Milano, Domenico De Bellis, Francesco Laterza, Assunta Pandolfi, Caterina Pipino, Michele Sallese, Marco Marchisio, Sebastiano Miscia, Matteo Neri, Paola Lanuti
Summary: Extracellular vesicles (EVs) play important roles in intercellular communication, homeostasis maintenance, and diseases. This study aimed to assess and characterize circulating EVs in celiac disease patients and patients on a gluten-free diet (GFD) using a novel flow cytometry technique. The results showed significantly increased total EV counts in both newly diagnosed celiac disease patients and patients on GFD, while endothelial-derived and epithelial-derived EV counts were significantly decreased in subjects on gluten exclusion. These findings indicate that EVs could serve as potential disease-specific biomarkers in celiac disease.
Article
Environmental Sciences
Ilenia Rosa, Chiara Conti, Luigia Zito, Konstantinos Efthymakis, Matteo Neri, Piero Porcelli
Summary: This longitudinal study examined the impact of disease activity change on the health-related quality of life (HRQoL) of patients with inflammatory bowel disease (IBD) during the COVID-19 pandemic. The results showed that COVID-19-related post-traumatic symptoms did not significantly differ across different disease activity groups, while HRQoL was consistently higher in patients with persistent, quiescent disease activity. The study highlights the importance of considering disease-related factors rather than COVID-19-related symptoms in managing the burden of disease for IBD patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Michele Sallese, Konstantinos Efthymakis, Michele Marchioni, Benedetto Neri, Beatrice Dufrusine, Enrico Dainese, Marta Di Nicola, Matteo Neri
Summary: Coeliac disease (CeD) is an immune-mediated disorder triggered by gluten, involving autoimmune damage to the intestines and other systems. The Th1 inflammatory response and innate immune response play important roles in its pathogenesis. Gene expression analysis found key cytokines and immune pathways involved. Comparison with non-celiac gluten sensitivity (NCGS) revealed molecular overlap, suggesting a common root (dysregulated long non-coding RNAs) for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Angelo Milano, Konstantinos Efthymakis, Damiano D'Ardes, Marco Tana, Elena Mazzotta, Giulia De Febis, Francesco Laterza, Pierluigi Tarquini, Enrico Marini, Ettore Porreca, Francesco Cipollone, Matteo Neri
Summary: This study investigates gastrointestinal symptoms in COVID-19 patients and finds that these symptoms may be part of the infection. Although patients with gastrointestinal symptoms require faster hospital admission, prognosis is not affected.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Pierluigi Puca, Valentina Petito, Lucrezia Laterza, Loris Riccardo Lopetuso, Matteo Neri, Federica Del Chierico, Ivo Boskoski, Antonio Gasbarrini, Franco Scaldaferri
Summary: Obesity is a major health issue worldwide, with bariatric surgery playing a key role in its management. The microbiota has been studied for its role in obesity pathogenesis and bariatric surgery outcomes, with changes in microbiome composition being associated with both diet and surgical interventions. Studies on the effects of modifying microbiota with interventions like fecal microbiota transplantation and probiotics are being conducted to identify eligible patients for bariatric surgery and predict their outcomes.
THERAPEUTIC ADVANCES IN GASTROINTESTINAL ENDOSCOPY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
M. Ribolsi, P. Zentilin, R. Penagini, K. Efthymakis, A. Mauro, G. De Carlo, M. Cicala, M. Neri
DIGESTIVE AND LIVER DISEASE
(2020)
Meeting Abstract
Gastroenterology & Hepatology
K. Efthymakis, E. De Felicibus, F. Laterza, A. Milano, A. Bonitatibus, M. Neri
DIGESTIVE AND LIVER DISEASE
(2020)
Article
Pharmacology & Pharmacy
F. Scaldaferri, G. Angelino, E. F. Romeo, L. R. Lopetuso, O. Ricca, S. Filoni, E. Borrelli, F. Torroni, S. Faraci, F. Rea, V Giorgio, M. Pizzoferrato, A. Poscia, D. Ferrarese, G. Camardese, M. Neri, A. Armuzzi, L. Dall'Oglio, A. Gasbarrini, P. De Angelis
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Konstantinos Efthymakis, Giuseppina Bologna, Paola Lanuti, Pasquale Simeone, Gianpaolo Lupacchini, Lucrezia Viscioni, Marco Marchisio, Sebastiano Miscia, Matteo Neri
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)