Review
Nanoscience & Nanotechnology
SeongHoon Jo, In-Cheol Sun, Cheol-Hee Ahn, Sangmin Lee, Kwangmeyung Kim
Summary: The blood-brain barrier poses a challenge to the delivery of imaging probes and therapeutic agents to the brain. Methods like ultrasound-mediated nano-particle delivery and photoacoustic brain imaging have emerged as potential solutions. Focused ultrasound is a popular means of enhancing drug delivery through temporary opening of the blood-brain barrier, while photoacoustic brain imaging uses light-to-heat conversion and ultrasound detection to visualize brain morphologies or diseases. The versatility of nanoparticles allows for successful brain imaging and treatment through the combined action of ultrasound and nanoparticulate agents.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Kangkang Ying, Bingjun Bai, Xing Gao, Yuzi Xu, Hangxiang Wang, Binbin Xie
Summary: Colorectal cancer is a common and lethal malignancy worldwide, but therapeutic outcomes in the clinic are currently unsatisfactory. Orally administrable nanoformulations have the potential to improve the bioavailability of therapeutic drugs, but there are still limitations associated with these regimes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Alexandro Azevedo, Dina Farinha, Carlos Geraldes, Henrique Faneca
Summary: Cancer is a prevalent and deadly disease in need of new preventive and treatment strategies. The fields of cancer nanomedicine and nanotheranostics offer opportunities for personalized and targeted therapy through combining imaging and therapeutic agents. Gene therapy is a promising approach that requires efficient delivery systems, and recent developments in theranostic nanosystems are exploring the integration of gene therapy and imaging for cancer treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemical Research Methods
Ruiyi Dai, Xiangrong Peng, Bi Lin, Danyang Xu, Ruichan Lv
Summary: A NIR II luminescence imaging and enhanced chemo-/photothermal therapy system for breast cancer and lymph node tracing has been proposed, utilizing CuS-DOX-Nd/FA NPs under single 808 nm irradiation. The system combines imaging and treatment capabilities to target tumors with high precision and efficiency for improved prognosis.
BIOCONJUGATE CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Diana Alves, Joana C. Araujo, Raul Fangueiro, Diana P. Ferreira
Summary: Cancer is a challenging global health problem, and localized therapeutic approaches based on micro/nanofibers show potential for its treatment. Micro/nanofibers offer advantages as drug delivery systems, such as high surface area, tunable pore size, and sustained release properties. Functionalization with nanoparticles enhances targeting and therapeutic capabilities. Studies show promising results in cancer models, but more research is needed for clinical use. Micro/nanofiber-based localized therapies hold promise for targeted and minimally invasive cancer treatment.
Article
Nanoscience & Nanotechnology
Hai-Jun Liu, Mingming Wang, Shanshan Shi, Xiangxiang Hu, Peisheng Xu
Summary: A Trojan horse strategy-based nanocarrier has been developed for the treatment of early-stage brain metastasis of breast cancer. This nanocarrier, integrating the cell membrane of a brain-homing cancer cell and a polymeric drug depot, shows enhanced cellular uptake and killing potency, as well as the ability to penetrate the blood-brain barrier. In animal experiments, it effectively extends survival time and reduces tumor burden.
NANO-MICRO LETTERS
(2022)
Review
Pharmacology & Pharmacy
Natalia Krasteva, Milena Georgieva
Summary: Colorectal cancer is a global health problem with increasing incidence and limited treatment options. Recent advances in nanomaterials, particularly graphene oxide nanoparticles, offer promising approaches for targeted therapy. Graphene oxide can kill cancer cells, deliver drugs and genes, and be used in phototherapy. Clinical trials are underway, and some nanomaterial-based treatments have already been approved.
Review
Nanoscience & Nanotechnology
Xiaolin Yan, Shanshan Li, Haiyin Yan, Chungang Yu, Fengxi Liu
Summary: The burden of cancer-related morbidity and mortality is rapidly increasing worldwide. Medical imaging, particularly using iron oxide nanoparticles (IONPs), plays a crucial role in the diagnosis, staging, treatment planning, and evaluation of cancer. IONPs can serve as contrast agents or labeling agents to enhance the identification and visualization of pathological tissues and target cells. This review highlights the recent research advances and discusses the challenges and future development of IONPs-based medical imaging in cancer management.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Haoan Wu, Xingchun Gao, Yuanyuan Luo, Jiang Yu, Gretchen Long, Zhaozhong Jiang, Jiangbing Zhou
Summary: The development of multifunctional polymeric nanoparticles for effective treatment of GBM is reported. The nanoparticles are designed to penetrate brain tumors through neutrophil elastase-triggered shrinkability, iRGD-mediated targeted delivery, and lexiscan-induced autocatalysis.
Review
Pharmacology & Pharmacy
Xiaoran Yin, Yifan Cheng, Yan Feng, Wesley R. Stiles, Seung Hun Park, Homan Kang, Hak Soo Choi
Summary: Phototheranostics combine light-induced therapeutic and diagnostic modalities to diagnose and treat human diseases. The development of nanomedicines and bioimaging has led to the advancement of phototheranostics, which show potential in improving treatment efficacy and minimizing side effects.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Linkang Xiao, Yunfang Wu, Junyong Dai, Weili Zhang, Yang Cao
Summary: Prostate cancer is a common malignant tumor in men, and Prostate-specific membrane antigen (PSMA) can serve as a potential therapeutic target due to its overexpression on prostate cancer cells. Image-guided and targeted therapy for prostate cancers using PSMA-targeting nanoparticles has gained much attention. In this study, PSMA-targeted light-responsive nanosystems loaded with the photosensitizer IR780 and the therapeutic drugs paclitaxel were developed. The nanosystems performed ultrasound-enhanced imaging and photothermal therapy guided by photoacoustic imaging, leading to excellent inhibition of cell proliferation in vitro and a significant therapeutic effect in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biophysics
Simranjit Singh, Venkata Sai Akhil Varri, Kinnari Parekh, Superb K. Misra
Summary: In this study, different types of nanoparticles were synthesized and optimized for hyperthermia treatment. Trastuzumab, a breast cancer drug, was chemically tethered onto the nanoparticles, improving their uptake in cancer cells and enhancing the therapeutic effect under hyperthermia.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Md Ali Mujtaba, Nawaf M. Alotaibi, Sultan M. Alshehri, Mohammad Yusuf, Md Khalid Anwer, Mohammad Akhlaquer Rahman, Arshiya Parveen
Summary: This study successfully optimized and formulated APG-loaded PEGylated chitosan nanoparticles through ionic gelation techniques using the Box-Behnken design. The optimized formulation showed desirable physical properties and significant anticancer potential. The study highlighted the efficacy of the Box-Behnken design in optimizing nanoparticle formulation and recognizing the impacts of formulation variables.
Article
Chemistry, Multidisciplinary
Emile F. van Vliet, Maarten J. Knol, Raymond M. Schiffelers, Massimiliano Caiazzo, Marcel H. A. M. Fens
Summary: Parkinson's disease is characterized by degeneration of dopaminergic neurons, causing dopamine deficiency and motor symptoms. Current treatment using L-DOPA has limitations and side effects. Encapsulation of L-DOPA into nanoparticles can protect it and improve delivery to the brain, reducing required dosages and side effects. Alternative delivery methods, such as intravenous administration and transdermal delivery, enhance therapeutic effects. This review discusses recent advances and future perspectives on NP-mediated L-DOPA delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Safi Ur Rehman Qamar
Summary: Nanotechnologies have made significant contributions to treating cancer and infectious diseases by using nanocomposites to deliver specific drugs or genes to target sites in the human body. Among various nanoparticles, silver nanoparticles have been the most extensively explored. The remarkable properties of nanocomposites, such as excellent antimicrobial, anticancer, and anti-inflammatory activities, have led to their advanced applications in diagnosing and treating diseases.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Oncology
Christian Bacci, Alessia Cerrato, Elisa Bardhi, Anna Chiara Frigo, Selma Ahcene Djaballah, Stefano Sivolella
Summary: This study assessed the efficacy of different preventive dental visits and treatments in reducing the risk of medication-related osteonecrosis of the jaws (MRONJ). The results indicated that compliance with specialist recommendations can reduce the risk of MRONJ for patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Pharmacology & Pharmacy
Giulia Brunello, Federica Zanotti, Martina Trentini, Ilaria Zanolla, Elham Pishavar, Vittorio Favero, Riccardo Favero, Lorenzo Favero, Eriberto Bressan, Massimo Bonora, Stefano Sivolella, Barbara Zavan
Summary: This study found that EXOs derived from dental pulp stem cells of different age donors have varying effects on MSCs. The younger donor group showed a more significant influence on proliferation and commitment ability.
Review
Medicine, General & Internal
Stefano Sivolella, Giulia Brunello, Sourav Panda, Lucia Schiavon, Fouad Khoury, Massimo Del Fabbro
Summary: This scoping review presents the outcomes of bone lid technique in oral surgery, focusing on bone healing, ridge preservation, and incidence of complications. The review also considers the instruments and methods used for bone cutting and stabilization. Overall, the bone lid technique shows favorable bone healing outcomes and a low incidence of major complications, although evidence-based studies are still limited.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Luca Sbricoli, Sara Ricci, Andrea Cattozzo, Riccardo Favero, Eriberto Bressan, Stefano Sivolella
Summary: This study presents a novel technique that combines surgical and orthodontic approaches to retrieve impacted second molars. The technique involves extraction of the third molar, placement of a distally positioned screw, and the use of a coil spring to connect the screw to the second molar. The results show successful repositioning of impacted second molars with minimal complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Giulia Brunello, Nikolaos Donos, Stefano Sivolella, Barbara Zavan
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Giulia Brunello, Nicole Rauch, Kathrin Becker, Ahmad R. Hakimi, Frank Schwarz, Juergen Becker
Summary: This study aimed to evaluate the long-term clinical performance of two-piece zirconia implants in the posterior jaws over 9 years. The results showed a high survival rate for these implants, despite frequent mechanical and technical complications. Therefore, two-piece zirconia implants could be considered as a valid solution for replacing single teeth in the posterior jaws.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Giulia Brunello, Federica Zanotti, Gerard Scortecci, Lari Sapoznikov, Stefano Sivolella, Barbara Zavan
Summary: The aim of this in vitro study was to investigate the commitment and behavior of dental pulp stem cells (DPSCs) seeded onto two different grafting materials, human dentin particulate (DP) and deproteinized bovine bone matrix (BG), with those cultured in the absence of supplements. The results showed that the DPSCs can achieve dentin and bone regeneration on specific grafting materials and can be induced to differentiate into odontoblast-like and osteoblast-like cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Adolfo Di Fiore, Mattia Montagner, Stefano Sivolella, Edoardo Stellini, Burak Yilmaz, Giulia Brunello
Summary: This review aimed to explore the possible link between occlusal overload and peri-implant bone loss. The analysis of clinical studies showed a positive correlation between overload and crestal bone loss in seven included studies. However, the overall risk of bias in the included studies was moderate to serious, suggesting the need for further investigation using new digital tools.
JOURNAL OF CLINICAL MEDICINE
(2022)
Correction
Dentistry, Oral Surgery & Medicine
Lucia Schiavon, Alessandro Perini, Giulia Brunello, Giada Ferrante, Massimo Del Fabbro, Daniele Botticelli, Fouad Khoury, Stefano Sivolella
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Schiavon Lucia, Perini Alessandro, Brunello Giulia, Ferrante Giada, Del Fabbro Massimo, Botticelli Daniele, Khoury Fouad, Sivolella Stefano
Summary: Analysis showed that in animal studies, rabbits had more new bone formation at 2 and 8 weeks when using the bone lid. Two clinical studies investigated lateral sinus lift with concomitant implant placement and reported similar results with high short-term implant success rates in both test and control groups.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Luca Sbricoli, Lucia Schiavon, Giulia Brunello, Paola Brun, Kathrin Becker, Stefano Sivolella
Summary: This study evaluated the effectiveness of antiseptic mouthwashes in reducing the SARS-CoV-2 load clinically and in vitro. The results showed that mouthwashes were effective in decreasing the viral load in saliva. However, there were certain biases in the studies and a high degree of heterogeneity in the results. Therefore, large-scale trials are still needed to determine the best rinsing protocols.
JAPANESE DENTAL SCIENCE REVIEW
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sandra Kallab, Frank Schwarz, Juergen Becker, Giulia Brunello
Summary: Zirconia implants have been proven as a promising alternative to conventional titanium implants, and a nine-year follow-up study provides further evidence of their long-term success. This study's results have been consolidated alongside other contemporary evidence.
Article
Endocrinology & Metabolism
Robert Kerberger, Giulia Brunello, Dieter Drescher, Bert van Rietbergen, Kathrin Becker
Summary: This study aimed to evaluate the impact of local stresses on implant migration and bone remodelling. The results showed that the magnitude of local stresses influenced bone remodelling and it can be speculated that stress-related bone resorption favored implant migration. After initial bone loss, net bone gain representing consolidation was observed.
Article
Dentistry, Oral Surgery & Medicine
Lucia Schiavon, Alessandro Perini, Rocco Borrello, Paolo Boldrin, Stefano Sivolella
Summary: Odontogenic cutaneous sinus tracts are often misdiagnosed as non-dental related pathologies due to their atypical morphology, extraoral location, and lack of dental symptoms. Correct diagnosis and rapid resolution can be achieved by considering the dental etiology and performing endodontic treatment or tooth extraction.
MINERVA DENTAL AND ORAL SCIENCE
(2022)
