Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1779, Issue 1, Pages 60-65Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2007.10.004
Keywords
CTLA4; 3' UTR; gene regulation; (AT)n polymorphism; autoimmune disease
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Funding
- Telethon [GJT04005] Funding Source: Medline
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T cell activation results from the integration of signals generated through the T cell antigen receptor-CD3 complex with those from additional positive and negative regulatory pathways mainly mediated by the engagement of costimulatory receptors on T cells. Disruption of this balance leads to a defective immune response or alternative over-activation of the immune system. CTLA-4 plays a critical role in downregulating T cell responses. Autoimmune diseases have shown genetic linkage to the CTLA4 locus. In this report we demonstrate that the 3' UTR of CTLA4 regulates firefly luciferase reporter gene expression, can confer instability to CTLA4 mRNA and can influence its translation efficiency in vitro. (c) 2007 Elsevier B.V. All rights reserved.
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