Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1828, Issue 12, Pages 2916-2925Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2013.05.012
Keywords
Intramembrane proteolysis; Substrate; Mitochondrial fusion; Apoptosis; Mitophagy
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Funding
- Canadian Institutes of Health and Research (CIHR)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Parkinson Society Canada
- Michael J. Fox Foundation for Parkinson's Research
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The Rhomboid proteases belong to a highly conserved family of proteins that are present in all branches of life. In Drosophila, the secretory pathway-localized rhomboid proteases are crucial for epidermal growth factor (EGF) signaling. The identification of a mitochondrial-localized rhomboid protease shed light on other functions of rhomboid proteases including the maintenance of mitochondrial morphology and the regulation of apoptosis. More recent work has revealed other functions of the mitochondrial rhomboid protease in mitochondrial and cellular biology, failure of which have been implicated in human diseases. In this review, we will summarize the current knowledge and disease relevance of the mitochondrial-localized rhomboid protease. This article is part of a Special Issue entitled: Intramembrane Proteases. (C) 2013 Elsevier B.V. All rights reserved.
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