Article
Engineering, Biomedical
Binbin He, Jianhai Yang, Yang Liu, Xianhua Xie, Huijie Hao, Xiaoli Xing, Wenguang Liu
Summary: The study introduces a novel vitreous substitute based on zwitterionic polymer hydrogel, which exhibits excellent anti-fouling ability and biocompatibility, effectively reducing inflammatory responses and complications.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Alexander E. G. Baker, Hong Cui, Brian G. Ballios, Sonja Ing, Peng Yan, Joe Wolfer, Thomas Wright, Mickael Dang, Nicola Y. Gan, Michael J. Cooke, Arturo Ortin-Martinez, Valerie A. Wallace, Derek van der Kooy, Robert Devenyi, Molly S. Shoichet
Summary: The study developed a new hyaluronan-oxime crosslinked hydrogel as a vitreous substitute, which has similar physical properties to the native vitreous. It showed good cytocompatibility and biocompatibility in vitro with mouse retinal explants and in rabbit eyes, demonstrating stability and limited swelling.
Article
Chemistry, Applied
Shuo Wang, Jinhua Chi, Zhiwen Jiang, Huiwen Hu, Chaozhong Yang, Wanshun Liu, Baoqin Han
Summary: The study developed a biocompatible, self-repairing, and in-situ injectable hydrogel using CMCTS and OHA as a vitreous substitute. The hydrogel showed good cytocompatibility on mouse fibroblast L929 and histocompatibility in New Zealand Rabbits, without significant and persistent adverse effects observed.
CARBOHYDRATE POLYMERS
(2021)
Review
Engineering, Biomedical
Ting Wang, Ruijin Ran, Yan Ma, Ming Zhang
Summary: Vitreoretinal surgery is crucial for treating various eye diseases, with the development of polymer hydrogels as potential ideal vitreous substitutes facing challenges. The review focuses on the advancements in natural-based and synthetic hydrogels, particularly emphasizing on stimuli-response and self-assembly supramolecular hydrogels.
BIOMEDICAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Junyan Tan, Yuning Luo, Yuqiong Guo, Yue Zhou, Xinying Liao, Dingxilei Li, Xinyi Lai, Yang Liu
Summary: Natural polysaccharide-based hydrogels, especially alginate, have become a research hotspot due to their abundant source, biodegradability, biocompatibility, solubility, and modification flexibility. Various crosslinking strategies and the application progress of alginate-based hydrogels in drug delivery, wound healing, and tissue engineering are comprehensively discussed in this article. The future prospects, challenges, and development trends of alginate-based hydrogels are also explored.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Xingxing Liu, Liheng Gao, Sijia Fu, Wenshuo Zhao, Fujun Wang, Jing Gao, Chaojing Li, Hao Wu, Lu Wang
Summary: The management of the interface between the wound microenvironment and the skin substitute (SSS) is essential for wound repair and tissue regeneration. A polycaprolactone fiber-alginate hydrogel interpenetrated network scaffold with multifunctional modifications has been developed. The scaffold exhibits excellent water absorption, water vapor permeability, and stretching properties. It also has antibacterial and reactive oxygen scavenging properties, as well as the ability to promote fibroblast cell proliferation. This scaffold is expected to be an ideal candidate for repairing various types of damaged skin, especially those with excessive exudate.
MATERIALS & DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Yuning Luo, Junyan Tan, Yue Zhou, Yuqiong Guo, Xinying Liao, Li He, Dingxilei Li, Xinxin Li, Yang Liu
Summary: Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility and moisturizing effect, which can affect angiogenesis, inflammation, and cell behavior. HA-based hydrogels formed by physical or chemical crosslinking strategies have both the physiological function of HA and the skeleton function of hydrogel. However, natural HA-based hydrogels have limitations such as insufficient mechanical strength and susceptibility to degradation. Researchers have developed various HA-based multifunctional hydrogels with notable properties by modifying the structure, using novel crosslinking strategies, and introducing reactive molecules. These hydrogels have extended the application scope in anticancer drug delivery, cartilage repair, three-dimensional cell culture, skin dressing, and other fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Environmental
Ruixue Li, Yang Sun, Zhengwei Cai, Yang Li, Jian Sun, Wei Bi, Fei Yang, Qianrong Zhou, Tingjun Ye, Youcheng Yu
Summary: A novel peptide hydrogel (HA-c-CGRP) was constructed in this study, which sustained release highly bioactive CGRP and promoted BMSCs proliferation and osteoblast differentiation. The cocrosslinking HA-c-CGRP hydrogel accelerated new bone formation process with the highly bioactive peptide, showing promising prospect for healing defected bone tissue.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Shuqin Yu, Shuo Wang, Lixin Xia, Huiwen Hu, Mingyu Zou, Zhiwen Jiang, Jinhua Chi, Yijie Zhang, Hongjian Li, Chaozhong Yang, Wanshun Liu, Baoqin Han
Summary: A study has successfully prepared a thiolated hyaluronic acid (SH-HA) hydrogel as a vitreous substitute, which demonstrated excellent biocompatibility and intraocular compatibility in experimental rabbits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Polymer Science
Kathrina Lois M. Taaca, Eloise Prieto, Magdaleno R. Vasquez
Summary: This review discusses the evolution and different approaches for hydrogel preparation. It also presents plasma treatment as an enabling technology for tailoring hydrogel properties and explores the current uses of plasma-treated hydrogels.
Review
Engineering, Biomedical
Qianyu Lin, Jason Y. C. Lim, Kun Xue, Xinyi Su, Xian Jun Loh
Summary: This article discusses the common use and characteristics of vitreous endo-tamponades in the treatment of retinal conditions, and suggests the potential of polymeric hydrogels as an ideal alternative due to their advantageous properties. Various design strategies have been employed to develop polymeric hydrogel-based vitreous endo-tamponades, aiming to combine therapeutic effectiveness with patient comfort.
Article
Pharmacology & Pharmacy
Jose Hurst, Annekatrin Rickmann, Nele Heider, Christine Hohenadl, Charlotte Reither, Andreas Schatz, Sven Schnichels, Kai Januschowski, Martin S. Spitzer
Summary: The study demonstrated that highly viscously thiol-modified cross-linked hyaluronate showed good biocompatibility in rabbit eyes, making it a promising potential as a vitreous substitute over 6 months.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Polymer Science
Halimatuddahliana Nasution, Hamidah Harahap, Nisaul F. Dalimunthe, M. Hendra S. Ginting, Mariatti Jaafar, Orlando O. H. Tan, Hotmauli K. Aruan, Alief L. Herfananda
Summary: Hydrogels are polymer materials that can swell but are insoluble in water. The three-dimensional structure of hydrogels affects their properties. Hydrogels synthesized with natural polymers have better biocompatibility, while those with synthetic polymers have adjustable mechanical properties.
Article
Polymer Science
Beata Niemczyk-Soczynska, Pawel Sajkiewicz, Arkadiusz Gradys
Summary: This study explains the mechanism of gelation in methylcellulose (MC) through differential scanning calorimetry (DSC), and finds that gelation is a multistep reversible thermal process. Three endotherms were observed during heating for low MC concentrations, which provides new insights compared to previous research.
Article
Engineering, Biomedical
Indu Yadav, Shiv Dutt Purohit, Hemant Singh, Neeladrisingha Das, Partha Roy, Narayan Chandra Mishra
Summary: A tri-polymer complex in situ hydrogel has been developed as a potential vitreous substitute, formed by crosslinking HA, Coll, and PEG. The hydrogels are biocompatible, transparent, elastic, injectable, and have a high water content, showing promise for vitreous replacement in ophthalmic diseases.
BIOMEDICAL MATERIALS
(2021)
Letter
Ophthalmology
Ana Luiza Fontes de Azevedo Costa, Thiago Goncalves dos Santos Martins, Paulo Schor
Article
Ophthalmology
Thiago Goncalves dos Santos Martins, Aytan Miranda Sipahi, Fabiana Maria dos Santos, Paulo Schor, Andreas Anschuetz, Luis Guilherme Arneiro Mendes, Rufino Silva
Summary: The main ophthalmological manifestations of patients with celiac disease, Crohn's disease and ulcerative colitis were dry eye and cataract. None of the three diseases showed increased intraocular pressure.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Education, Scientific Disciplines
Thiago Goncalves dos Santos Martins, Paulo Schor, Jose Augusto Stuchi, Susan B. Fowler
Summary: Ophthalmic diseases can indicate systemic diseases in animals, so veterinarians must master fundus examination techniques. To facilitate learning, a teaching methodology using a low-cost model and device has been developed to teach students direct and indirect ophthalmoscopy techniques in veterinary medicine.
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2022)
Article
Ophthalmology
Gustavo Rosa Gameiro, Giovana Rosa Gameiro, Michel Eid Farah, Jianhua Wang, Paulo Schor
Summary: This study focuses on the correlation between changes in the retinal microvascular plexus and the water drinking test (WDT) in young healthy subjects. Results showed that WDT resulted in temporary modifications of the deep vascular plexus in addition to increased intraocular pressure (IOP) and changes in heart rate (HR) in young healthy subjects.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Engineering, Biomedical
Ramon Antunes de Oliveira, Felipe Picanco Muralha, Alex Treiger Grupenmacher, Andreia de Araujo Morandim-Giannetti, Patricia Alessandra Bersanetti, Mauricio Maia, Octaviano Magalhaes Junior
Summary: The study evaluated the biocompatibility of PVA/SMTP hydrogel as a vitreous substitute in rabbit eyes, showing opacification and adverse effects on the retina. Further analysis of novel biomaterials in vivo is recommended.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Medicine, General & Internal
Ana Luiza Fontes de Azevedo Costa, Thiago Goncalves dos Santos Martins, Vagner Rogerio dos Santos, Paulo Schor
Summary: Developing multisensory sleeves to aid in the identification of eye drops can help patients avoid misidentification and increase autonomy. Survey results showed that most patients believe these sleeves can reduce the risk and enhance safety in using eye drops.
SAO PAULO MEDICAL JOURNAL
(2022)
Article
Ophthalmology
Cristina Cagliari, Paulo Schor, Luiz Formentin, Cesar Lipener, Myrna Serapiao dos Santos, Helena Oliveira, Jose Ney de Carvalho Raulino Junior, Denise de Freitas
Summary: This study aimed to investigate the corneal alterations in patients with keratoconus who wore scleral contact lenses (ScCLs), with a specific focus on corneal endothelial assessment. The results showed that there were no adverse effects on the cornea or endothelium over a 90-day period of wearing ScCLs, and there was no evidence of disease progression.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Rogerio L. da Silva, Athanasios Papakyriakou, Adriana K. Carmona, Georgios A. Spyroulias, Edward D. Sturrock, Patricia A. Bersanetti, Clovis R. Nakaie
Summary: The renin-angiotensin system (RAS) plays a crucial role in regulating arterial pressure in humans. ACE inhibitors are commonly used for hypertension and heart-related diseases, prompting research into domain-specific ACE inhibitors. Angiotensin (1-7) and Ac-Ang (2-7)-NH2 have shown promise as ACE inhibitors with improved selectivity.
BIOORGANIC CHEMISTRY
(2022)
Article
Thermodynamics
Patricia Alessandra Bersanetti, Aline de Assis Marquini, Andreia De Araujo Morandim-Giannetti
Summary: This study analyzed the effects of Stryphnodendron adstringens butanolic extract on corneal stroma cross-linking in porcine eyes. The results showed that the extract increased the number of cross-links in the corneas, resulting in improved resistance to thermal and enzymatic degradation.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Review
Medicine, General & Internal
Thiago Goncalves Dos Santos Martins, Paulo Schor, Luis Guilherme Arneiro Mendes, Susan Fowler, Rufino Silva
Summary: This review provides an overview of the applications of artificial intelligence (AI) in ophthalmology and discusses the limitations and challenges associated with implementing and developing this technology. AI serves as a complement and innovation in the daily practice of ophthalmologists, enhancing service accuracy and advancing scientific research.
SAO PAULO MEDICAL JOURNAL
(2022)
Letter
Medicine, General & Internal
Thiago Goncalves dos Santos Martins, Gabriel Lima Benchimol, Gustavo Rosa Gameiro, Paulo Schor
EINSTEIN-SAO PAULO
(2022)
Article
Medicine, General & Internal
Thiago Goncalves dos Santos Martins, Paulo Schor, Luis Guilherme Arneiro Mendes, Andreas Anschuetz, Rufino Silva
Summary: The most common ophthalmologic disorders in pregnant women seen in a hospital in Munich were analyzed using a big data analysis system. Dry eye, conjunctivitis, and ametropia were found to be the most prevalent conditions, while diabetic retinopathy was the most common posterior segment problem. The use of a data warehouse proved to be valuable for data acquisition and analysis.
EINSTEIN-SAO PAULO
(2022)
Article
Ophthalmology
Priscila Rymer, Bernardo Kaplan Moscovici, Rachel Gomes, Braulio Couto, Paulo Schor, Mauro Campos
Summary: This study compared postoperative pain and discomfort between mechanical and transepithelial photorefractive keratectomies and found that mechanical photorefractive keratectomy had significantly lower pain scores on the first postoperative day, leading to greater patient preference for this technique.
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
(2022)
Article
Education, Scientific Disciplines
Thiago Goncalves dos Santos Martins, Paulo Schor, Jose Augusto Stuchi, Susan B. Fowler
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2022)
Review
Medicine, General & Internal
Thiago Goncalves dos Santos Martins, Diogo Goncalves dos Santos Martins, Thomaz Goncalves dos Santos Martins, Paula Marinho, Paulo Schor
Summary: The new coronavirus of 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, leading to ocular manifestations in some patients. More research is needed to fully understand the implications of COVID-19 on ophthalmology.
SAO PAULO MEDICAL JOURNAL
(2021)
