Article
Biology
Beata Machnicka, Aleksander Czogalla, Dzamila M. Boguslawska, Piotr Stasiak, Aleksander F. F. Sikorski
Summary: A new missense mutation in the ANK1 gene associated with hereditary spherocytosis phenotype is reported. This mutation, L1340P substitution, affects the conformation of the ankyrin ZZUD domain important for ankyrin binding to spectrin. The study shows the impact of this mutation on protein binding activity and cell morphology.
Review
Cardiac & Cardiovascular Systems
Drew Nassal, Jane Yu, Dennison Min, Cemantha Lane, Rebecca Shaheen, Daniel Gratz, Thomas J. Hund
Summary: The cardiac conduction system relies on proper ion channel regulation for normal function, and defects in ion channels can lead to cardiac arrhythmias. Adapter and cytoskeletal proteins are crucial for organizing ion channel complexes, with ankyrin and spectrin families playing important roles in myocytes throughout the conduction system. Dysfunction in these proteins may contribute to conduction disturbances and cardiac arrhythmias, highlighting their potential therapeutic significance.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Article
Hematology
Shan Li, Ping Guo, Leyuan Mi, Xiaojing Chai, Kewang Xi, Ting Liu, Li Lu, Juan Li
Summary: In this study, a novel mutation of the SPTB gene was identified in a Chinese family with hereditary spherocytosis, and its pathogenicity and pathogenesis were investigated. The mutation disrupted the synthesis and interaction of proteins, leading to abnormal red cell morphology and hemolytic anemia.
ANNALS OF HEMATOLOGY
(2022)
Article
Neurosciences
Fulin Ma, Himanshu Akolkar, Jianquan Xu, Yang Liu, Dina Popova, Jiaan Xie, Mark M. Youssef, Ryad Benosman, Ronald P. Hart, Karl Herrup
Summary: It has been found that glutamate stimulation of neuronal activity leads to an increase in APP gene expression, which in turn affects the structure and function of neurons. APP is associated with the AIS structure protein in neurons, and increased levels of APP protein in AD patients result in AIS shortening and changes. These findings contribute to a reevaluation of the relationship between APP and AD.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Physical
Zhaojie Chai, Shiju Gu, George Lykotrafitis
Summary: Recently, it was discovered that the axon plasma membrane skeleton (APMS) is composed of actin rings and spectrin filaments, forming a network that enhances structural stability. However, the impact of APMS on axon deformation remains unknown. Through molecular dynamics simulations, it was found that the shape of the force-extension curve initially depends on the extension rate, but unfolding of spectrin repeats does not synchronize across filaments. If actin-spectrin associations remain intact, the force-extension response reaches a perfectly plastic region. However, at high extension rates, the APMS softens and the resistance force decreases until complete severance of APMS occurs. Furthermore, when the ring-to-ring distance is maintained fixed under stretch, the resistance force relaxes exponentially with time due to additional unfolding of spectrin tetramers.
Article
Biophysics
Zhaoji Chai, Anastasios V. Tzingounis, George Lykotrafitis
Summary: Recent studies have shown that axons have a periodic skeleton structure, which provides them with structural integrity and stability. The periodic arrangement of voltage-gated sodium channels has an impact on the generation and propagation of action potentials, and the distance between these periodic sodium channel strips can control axonal excitability.
BIOPHYSICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Inga Baasch Christensen, Lei Cheng, Jonathan R. Brewer, Udo Bartsch, Robert A. Fenton, Helle H. Damkier, Jeppe Praetorius
Summary: The research revealed that choroid plexus epithelium expresses multiple Na,K-ATPase subunits, forming complexes that interact with the microvillar cytoskeleton through actin or other proteins. Additionally, the expression of NKCC1 is necessary for the accumulation of Na,K-ATPase in the choroid plexus brush border.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Esben M. Quistgaard, Josephine Dannerso Nissen, Sean Hansen, Poul Nissen
Summary: The axon initial segment (AIS) plays a crucial role in neuronal signaling by initiating action potentials. Recent research has identified the proteins and molecular architecture of AIS, providing insights for future structural characterization. More studies are needed to explore the complex higher-order assemblies and improve structure predictions.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Arkadiusz Miazek, Michal Zalas, Joanna Skrzymowska, Bryan A. Bogin, Krzysztof Grzymajlo, Tomasz M. Goszczynski, Zachary A. Levine, Jon S. Morrow, Michael C. Stankewich
Summary: The study identified a strain of mice with a single spectrin mutation that affects its affinity to calmodulin and increases sensitivity to calpain proteolysis, leading to neurological abnormalities and lethality. This highlights the importance of substrate-level regulation of spectrin cleavage for neuronal integrity and suggests a potential role of spectrin damage in various neurodegenerative disorders.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Damaris N. N. Lorenzo, Reginald J. J. Edwards, Anastasia L. L. Slavutsky
Summary: Spectrins, encoded by genes such as SPTAN1, SPTBN1, SPTBN2 and SPTBN4, are implicated in neurological disorders. This review summarizes the diverse functions and organization of neuronal spectrins and provides insights into the pathophysiology of spectrinopathies, aided by functional studies in mouse models.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
A. Jollivet, P. Quach, M. Tchernycheva, R. Ferreira, E. Di Russo, L. Rigutti, B. Vinter, N. le Biavan, D. Lefebvre, M. Hugues, J-M Chauveau, F. H. Julien
Summary: We conducted a systematic investigation of intersubband transitions in nonintentionally doped m-plane ZnO/ZnMgO quantum wells. Our findings reveal that the huge exciton binding energy in the ZnO material system, further enhanced by quantum confinement in the quantum wells, leads to a significant blue shift in the peak transition energy. This discovery may contribute to a better understanding of semiconductors' excitonic processes and opens up possibilities for developing intersubband devices operating in a blue-shifted range.
Article
Biochemistry & Molecular Biology
Sansa Dutta, Dipayan Bose, Semanti Ghosh, Abhijit Chakrabarti
Summary: Cytoskeletal drugs have potential therapeutic benefits by acting on cytoskeletal components. This study investigates the interaction of popular cytoskeletal drugs with spectrin and their effect on actin cytoskeleton dynamics. The results indicate moderate affinity binding with the actin binding domain of spectrin, driven by entropy and hydrophobic interactions.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Dzamila M. Boguslawska, Michal Skulski, Beata Machnicka, Stanislaw Potoczek, Sebastian Kraszewski, Kazimierz Kuliczkowski, Aleksander F. Sikorski
Summary: Hereditary spherocytosis (HS) is the most commonly inherited hemolytic anemia in northern Europeans, with a new mutation identified through whole exome sequencing. Analysis of 71 genes associated with erythrocyte pathologies revealed only one SPTB gene variant that may be the molecular mechanism behind the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Tom Reichert, Marija Vucicevic, Paula Hillman, Marcus Bleicher, Sanja J. Armakovic, Stevan Armakovic
Summary: This study used DFT and SAPT calculations, along with MD simulations, to investigate the interaction between a sumanene molecule and 5-fluorouracil (5-FU). The results showed that 5-FU binds more strongly to the concave side of sumanene. Different geometric shapes of sumanene also influenced the interaction between sumanene and 5-FU.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Galal Magdy, Fathalla Belal, Ahmed Faried Abdel Hakiem, Ahmed M. Abdel-Megied
Summary: In this study, the binding interaction of cabozantinib with salmon sperm DNA (SS-DNA) was investigated under simulated physiological conditions using multiple experimental methods. The results indicated that cabozantinib binds to SS-DNA through hydrophobic and hydrogen bonding interactions, primarily via minor groove binding. Molecular docking analysis showed that cabozantinib fits into the AT-rich region of the B-DNA minor groove with a binding site of 4 base pairs long. Additionally, the flexibility of cabozantinib's structure, with eight active torsions, played a significant role in forming a stable cabozantinib-DNA complex.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Gastroenterology & Hepatology
Pallavi Subramanian, Sofia Gargani, Alessandra Palladini, Margarita Chatzimike, Michal Grzybek, Mirko Peitzsch, Anastasios D. Papanastasiou, Iryna Pyrina, Vasileios Ntafis, Bettina Gercken, Mathias Lesche, Andreas Petzold, Anupam Sinha, Marina Nati, Veera Raghavan Thangapandi, Ioannis Kourtzelis, Margarita Andreadou, Anke Witt, Andreas Dahl, Ralph Burkhardt, Robert Haase, Antonio Miguel de Jesus Domingues, Ian Henry, Nicola Zamboni, Peter Mirtschink, Kyoung-Jin Chung, Jochen Hampe, Unal Coskun, Dimitris L. Kontoyiannis, Triantafyllos Chavakis
Summary: The study found that hepatocyte-specific deficiency of HuR led to increased susceptibility to hepatic steatosis and fibrosis, as well as exacerbated inflammation, fibrosis, and HCC development on an NAFLD-inducing diet. The findings suggest that HuR plays a crucial role in maintaining liver homeostasis and preventing NAFLD-related fibrosis and HCC, indicating its potential therapeutic implications.
Review
Chemistry, Physical
Julia Jerzykiewicz, Aleksander Czogalla
Summary: In recent years, gene therapy for cancer treatment has gained increasing interest. Non-viral vectors, particularly lipopolyplexes consisting of nucleic acids condensed with polyvalent molecules and enclosed in lipid vesicles, show great promise as effective and safe nucleic acid carriers. This article briefly reviews the major aspects of developing such non-viral vectors based on polyethyleneimine and discusses their properties in relation to anticancer therapeutic strategies. Examples of current in vivo studies involving these lipopolyplexes and potential future developments are also presented.
Article
Cell Biology
Jolanta Zelasko, Aleksander Czogalla
Summary: This study investigated the specific recognition of different physiologically important phosphatidic acid (PA) species by the mTOR FRB domain and found that the length and saturation of PA acyl chains influence the binding of mTOR FRB domain to the membrane. Moreover, cholesterol was found to modulate the recognition of PA-FRB. These findings provide insights into the molecular details of physiological effects and reveal novel mechanisms for fine-tuning signaling cascades dependent on PA.
Article
Cell Biology
Agnieszka Biernatowska, Karolina Wojtowicz, Tomasz Trombik, Aleksander F. Sikorski, Aleksander Czogalla
Summary: In this study, we elucidate the crucial role of MPP1-flotillin complexes in the dynamic nanoscale organization of the plasma membrane (PM) in erythroid cells. These complexes regulate the immobilization of flotillin-based nanoclusters and control the local concentration of sphingomyelin and Thy-1 in raft nanodomains.
Review
Biochemistry & Molecular Biology
Lucyna Matusewicz, Marlena Golec, Aleksander Czogalla, Kazimierz Kuliczkowski, Adam Konka, Joanna Zembala-John, Aleksander F. Sikorski
Summary: The review discusses the current understanding of the mechanisms of SARS-CoV-2 and explores potential treatment approaches for COVID-19 based on this knowledge. Despite significant progress in antiviral therapy and prevention, there is still a need for new effective therapies.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Karolina Labedzka-Dmoch, Michal Razew, Marta Gapinska, Jakub Piatkowski, Adam Kolondra, Hanna Salmonowicz, Joanna M. Wenda, Marcin Nowotny, Pawel Golik
Summary: Pet127 is a mitochondrial protein with conserved presence and function in different eukaryotes. It is classified as a member of the PD-(D/E)XK superfamily and exhibits exoribonuclease activity. Deletion of the PET127 gene in pathogenic yeast leads to abnormal increase in transcript levels, indicating the important role of Pet127 protein in RNA degradation.
Article
Multidisciplinary Sciences
Michael Overduin, Troy A. Kervin, Anh Tran
Summary: Membrane recognition by viral spike proteins plays a critical role in virus infection. This study investigates the binding of different spike protein variants, including those from SARS-CoV-2 and related viruses, to host cell membranes. The results show that these variants exhibit increased membrane binding tendencies over time, with mutations in the spike head region, particularly in variant BA.1, affecting the affinity to cell membranes. Comparison of multiple structures reveals a progressive model of membrane docking, where spike protein trimers transition from perpendicular to tilted positions, facilitating viral particle adhesion to host cell membranes and potential engagement with ACE2 receptors. Enhanced membrane interactions in variants explain their unique cell fusion capacities and the transmission of COVID-19.
Article
Biochemistry & Molecular Biology
Dzamila M. Boguskawska, Michal Skulski, Rafal Bartoszewski, Beata Machnicka, Elzbieta Heger, Kazimierz Kuliczkowski, Aleksander F. Sikorski
Summary: This study reports two cases of hemolytic anemia in brothers of Polish origin with a very rare mutation associated with pyrimidine 5'-nucleotidase deficiency. Molecular analysis, including whole-exome sequencing and Western blot, identified the mutated phenotype of pyrimidine 5'-nucleotidase in the brothers' erythrocytes.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biology
Maryam Jama, Marawan Ahmed, Anna Jutla, Carson Wiethan, Jitendra Kumar, Tae Chul Moon, Frederick West, Michael Overduin, Khaled H. Barakat
Summary: This study utilized computational tools to screen over 6 million compounds and identified three potent allosteric inhibitors of SHP2. The binding affinities of these inhibitors to SHP2 were measured and found to be in the nanomolar range, suggesting their potential as improved allosteric inhibitors of SHP2.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Virology
Michael Overduin, Rakesh K. K. Bhat, Troy A. A. Kervin
Summary: Variants of the Omicron subvariants of SARS-CoV-2 exhibit strong membrane binding abilities and can evade antibodies from vaccinations and previous infections. Despite differences around mutated sites, they all maintain elevated membrane binding propensities and exhibit both closed and open states. These findings provide predictive criteria for future pandemic waves and strategies for combating multiple variants.
Review
Biochemistry & Molecular Biology
Michael Overduin, Anh Tran, Dominic M. Eekels, Finn Overduin, Troy A. Kervin
Summary: Transmembrane membrane readers (TMMRs) are a class of proteins that have both transmembrane and peripheral domains, playing important roles in membrane fusion and signal recognition. They have crucial functions in cell biology and membrane trafficking, and are considered as drug targets for diseases like COVID-19.
Article
Biology
Beata Machnicka, Aleksander Czogalla, Dzamila M. Boguslawska, Piotr Stasiak, Aleksander F. F. Sikorski
Summary: A new missense mutation in the ANK1 gene associated with hereditary spherocytosis phenotype is reported. This mutation, L1340P substitution, affects the conformation of the ankyrin ZZUD domain important for ankyrin binding to spectrin. The study shows the impact of this mutation on protein binding activity and cell morphology.
Article
Biochemistry & Molecular Biology
Dzamila M. Boguslawska, Sebastian Kraszewski, Michal Skulski, Stanislaw Potoczek, Kazimierz Kuliczkowski, Aleksander F. Sikorski
Summary: Hereditary spherocytosis (HS) is the most common non-immune hereditary hemolytic anemia in people of Caucasian central or northern European ancestry. In this study, a newly discovered AE1 variant p.G720W was found to be crucial in causing HS, and molecular dynamics simulation revealed significant changes in AE1 domain structure and possible alterations in AE1 function. The findings provide insight into the molecular mechanism underlying HS in this particular case.
Article
Biochemistry & Molecular Biology
Anh Tran, Troy A. Kervin, Michael Overduin
Summary: This study investigates the mechanism of interaction between the spike protein of SARS-CoV-2 and host cell membranes. Multiple binding sites between the spike protein and membranes are identified, which play a role in viral fusion, entry, assembly, and egress processes, as well as ACE2 receptor recognition. Antibodies targeting the spike protein block the membrane docking process that precedes ACE2 recognition.
CURRENT RESEARCH IN STRUCTURAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Philipp Grad, Katarina Edwards, Lars Gedda, Victor Agmo Hernandez
Summary: This study investigates the effects of polyethylene glycol-(PEG) modified lipids and gangliosides on the Ca2+ induced interaction between liposomes composed of palmitoyl-oleoyl phosphatidylethanolamine (POPE) and palmitoyl-oleoyl phosphatidylserine (POPS) at physiological ionic strength. The results show that naked liposomes tend to adhere, rupture, and collapse on each other's surfaces upon addition of Ca2+, eventually resulting in the formation of large multilamellar aggregates and bilayer sheets. However, the presence of gangliosides or PEGylated lipids leads to the formation of small, long-lived bilayer fragments/disks. PEGylated lipids seem to be more effective than gangliosides at stabilizing these structures. The study suggests that direct liposome-liposome fusion is not the dominating process triggered by Ca2+ in the systems studied.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Saurabh Saraswat, Archana Chugh
Summary: Cell penetrating peptides (CPP) are important tools for intracellular delivery of molecules. In this study, a novel marine-derived CPP from Engraulis japonicus, called Engraulisin, was reported. Engraulisin demonstrated successful cellular uptake and selective antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA), making it a potential candidate for drug delivery.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Niu, Si Jia Chen, Jeffery B. Klauda
Summary: Macrophage membranes in the activated state are more tightly packed, exhibit increased chain order across lipid species, and form specific lipid clusters. These findings provide physiologically accurate models for future computational studies of macrophage membranes and their proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Niki Baccile, Vincent Chaleix, Ingo Hoffmann
Summary: This study measured the bending rigidity of self-assembled structures formed by a new biobased glucolipid bioamphiphile using neutron spin-echo (NSE) technology. The results showed that the bending rigidity of these structures is lower or higher compared to phospholipid membranes, providing a new theoretical basis for the application of these new molecular systems.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Alain Bolano Alvares, Pablo E. A. Rodriguez, Gerardo D. Fidelio
Summary: The behavior of amphiphilic molecules at the air/water interface was studied to evaluate the arrangement formed in a confined area. The surface properties of zwitterionic DPPC lipid and A beta(1-40) amyloid peptide in mixed films were investigated at different temperatures. DPPC undergoes a phase transition depending on temperature and lateral pressure, which allows for the study of its influence on amyloid structure formation.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Lukasz Plachta, Marzena Mach, Magdalena Kowalska, Pawel Wydro
Summary: Resveratrol, a popular phytoalexin found in grapes and red wine, has beneficial effects on the cardiovascular system, exhibits antiviral, antibacterial, and antifungal properties, and may have therapeutic effects against cancer. This study investigates the interaction of resveratrol with model cell membranes, demonstrating changes in their physicochemical parameters and highlighting the role of cholesterol content in resveratrol incorporation. The findings suggest that the molecular mechanism of action of resveratrol may involve interactions with lipid rafts.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Edurne Rujas, Beatriz Apellaniz, Johana Torralba, David Andreu, Jose M. M. Caaveiro, Shixia Wang, Shan Lu, Jose L. Nieva
Summary: This study investigates the role of fusion peptide and Trp-rich membrane proximal external region in HIV-1 fusion and demonstrates that liposome-based formulations containing FP-MPER hybrid peptides can induce the production of specific neutralizing antibodies in rabbits. The results support the use of liposomes as vaccine carriers and the inclusion of lipid membranes in immunogens to elicit specific humoral responses.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Dailin Li, Dingyuan Shi, Lei Wang
Summary: G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in regulating cell excitability. This study investigated the ion permeation mechanism in GIRK2 mutants using molecular dynamic simulations and QM/MM methods. The results revealed the importance of a multi-ion distribution for ion conduction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Max J. den Uijl, Arnold J. M. Driessen
Summary: Membrane protein insertion into and translocation across the bacterial cytoplasmic membrane are essential processes facilitated by the Sec translocon. The phospholipid dependence of membrane protein insertion has remained mostly unknown. This study reveals that the insertion of the mannitol permease MtlA into the membrane depends on the presence of phosphatidylglycerol and is stimulated by phosphatidylethanolamine.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick Allen, Adam C. Smith, Vernon Benedicto, Abbas Abdulhasan, Vasanthy Narayanaswami, Enrico Tapavicza
Summary: We explore the stability, size, and structure of nanodiscs formed by the N-terminal domain of apolipoprotein E3 and a variable number of 1,2-dimyristoyl-sn-glycero-3-phosphocholine molecules. Our simulations suggest that nanodiscs containing 240 to 420 DMPC molecules are stable. The antiparallel configuration shows more protein-protein interactions and ionic contacts, as well as greater stability and rigidity compared to the parallel configuration.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick M. Keating, Nicholas P. Schifano, Xinrui Wei, Matthew Y. Kong, Jinwoo Lee
Summary: Lassa virus (LASV) infection is dependent on the fusion of its viral membrane with the host cell membrane, and our study reveals that this fusion process involves pH-dependent conformational changes in the transmembrane domain of LASV. These findings provide valuable insights into the fusion mechanism of LASV and can be utilized in the design of therapeutics to combat Lassa virus infections and prevent its potential spread.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Ashley L. Bennett, Kristen N. Cranford, Austin L. Bates, Christopher R. Sabatini, Hee-Seung Lee
Summary: This study employed molecular dynamics simulations to elucidate the binding, folding, and insertion details of TP10W in the cell membrane. The simulations revealed that TP10W can translocate across the lipid membrane as a monomer, and the charged amino acid side chains can move between lipid leaflets. Comparison with point mutated variants demonstrated significant conformational changes due to charge distribution.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Jessica H. van Wonderen, Jason C. Crack, Marcus J. Edwards, Thomas A. Clarke, Gerhard Saalbach, Carlo Martins, Julea N. Butt
Summary: Electrogenic bacteria transfer excess respiratory electrons to metal oxide particles and electrodes through the MtrCAB complex. The crystal structure of MtrCAB from S. baltica OS185 was resolved, and liquid chromatography mass spectrometry was used to determine the mass values of the three proteins in purified MtrCAB complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Review
Biochemistry & Molecular Biology
Yi-Ming Chen, Ching-Tai Lu, Chia-Wen Wang, Wolfgang B. Fischer
Summary: A series of dye ligands were ranked based on docking experiments, selecting the most suitable ligands for binding with different proteins. Additionally, a comparison study was conducted on a series of repurposing drugs and known antivirals.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
