Polyreactivity of natural antibodies: Exchange by HL-fragments

Human Milk IgGs Contain Various Combinations of Different Antigen-Binding Sites Resulting in Multiple Variants of their Bispecificity

(2012) Sergey E. Sedykh et al.   PLoS One

Human Milk sIgA Molecules Contain Various Combinations of Different Antigen-Binding Sites Resulting in a Multiple Binding Specificity of Antibodies and Enzymatic Activities of Abzymes

(2012) Sergey E. Sedykh et al.   PLoS One

Reactivity profiles of broadly neutralizing anti-HIV-1 antibodies are distinct from those of pathogenic autoantibodies

(2011) Harvir Singh et al.   AIDS

Polyreactive antibodies in adaptive immune responses to viruses

(2011) Hugo Mouquet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific

(2011) Julia Benckert et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneous antigen recognition behavior of induced polyspecific antibodies

(2010) Jordan D. Dimitrov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activity in sepsis

(2010) Iglika K. Djoumerska-Alexieva et al.   FEBS Journal

Structure and function of immunoglobulins

(2010) Harry W. Schroeder et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular analysis of multicatalytic monoclonal antibodies

(2010) Haggag S. Zein et al.   MOLECULAR IMMUNOLOGY

Hybrid IgG4/IgG4 Fc antibodies form upon ‘Fab-arm’ exchange as demonstrated by SDS-PAGE or size-exclusion chromatography

(2010) Theo Rispens et al.   MOLECULAR IMMUNOLOGY

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

(2010) Hugo Mouquet et al.   NATURE

Going Adaptive

(2009) Nadia Danilova et al.   Annals of the New York Academy of Sciences

Polyreactive antibodies in multidonor-derived immunoglobulin G: Theory and conclusions drawn from experiments

(2009) Peter Gronski et al.   IMMUNOBIOLOGY

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY

Effect of Intravenous Immunoglobulin Therapy on Serum Levels of IgG1 and IgG4 Antidesmoglein 1 and Antidesmoglein 3 Antibodies in Pemphigus Vulgaris

(2008) Michelle G. Green et al.   ARCHIVES OF DERMATOLOGY

Monomerization of dimeric IgG of intravenous immunoglobulin (IVIg) increases the antibody reactivity against intracellular antigens

(2008) Sandra Wymann et al.   MOLECULAR IMMUNOLOGY

Multiple diverse ligands binding at a single protein site: A matter of pre-existing populations

(2002) Buyong Ma et al.   PROTEIN SCIENCE