Journal
ANALYST
Volume 140, Issue 9, Pages 2973-2978Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5an00232j
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Funding
- CETC Technological Innovation Fund [JJ-QN-2013-35]
- National Natural Science Foundation of China [21305142]
- Natural Science Foundation of Anhui Province [1308085QB27]
- Cultivation Project for the NSFC Youth Foundation of the First Affiliated Hospital of Anhui Medical University [2013KJ05]
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A novel and simple platform for an efficient SERS detection was demonstrated in a hanging plasmonic droplet of Ag sols by virtue of three-dimensional (3D) SERS hotspots. The platform was a single droplet of concentrated Ag sols with analytes hung on a hydrophobically treated transparent cover glass. Liquid adhesive force, solvent evaporation, and hydrophobic interaction induced a concentration of dense nanoparticles into a 3D space. The generated 3D hotspots enable the highly-sensitive detection of ultratrace analytes and simultaneous multiplex identification of different amino acids, which are well-known molecules with low Raman cross-sections. This platform demonstrates an excellent mechanical stability and is suitable for the excellent examination of ultratrace analytes, with detection limits as low as 0.01 fmol of dye molecules and 5 pmol of amino acids with extremely low Raman cross-sections.
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