Article
Psychiatry
S. Dominguez-Alonso, A. Carracedo, C. Rodriguez-Fontenla
Summary: Autism Spectrum Disorders (ASD) is a group of neurodevelopmental disorders characterized by difficulties in social interaction and communication. The study uses a newly developed tool called eQTpLot to analyze the largest ASD GWAS data, along with GWAS summary statistics from other studies, to identify genes associated with ASD.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Plant Sciences
Fei-Hua Yao, Xiao Liang, Xin-Hua Lu, Xia Cheng, Lian-Xiang Luo, Shu-Hua Qi
Summary: Seven new decahydrofluorene-class alkaloids, pyrrospirones K-Q (1-7), were isolated from the marine-derived fungal strain Penicillium sp. SCSIO 41512. Compound 13 exhibited significant inhibitory activity against protein tyrosine phosphatases. Moreover, compounds 1, 2, 5, 8-10, 12, and 13 showed antibacterial activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Rory M. Crean, Michal Biler, Marc W. van der Kamp, Alvan C. Hengge, Shina C. L. Kamerlin
Summary: This study investigates the link between the dynamics of the WPD-loop and catalysis rates in human protein tyrosine phosphatase 1B (PTP1B) and YopH from Yersinia pestis. Computational simulations reveal key residues and structural features responsible for differences in loop dynamics, as well as pathways for allosteric communication in these enzymes. The findings shed light on how PTP enzymes in the family may adapt to environmental changes and regulate their catalytic activities.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Malathi Bheri, Swati Mahiwal, Sibaji K. Sanyal, Girdhar K. Pandey
Summary: Protein phosphorylation and dephosphorylation are important reversible post-translational modifications, with protein phosphatases playing a key role in signaling networks. The classification and mechanism of phosphatases in plant systems still require further investigation.
Review
Biochemistry & Molecular Biology
Andrew M. Mattei, Jonathan D. Smailys, Emma Marie Wilber Hepworth, Shanta D. Hinton
Summary: Pseudophosphatases, atypical members of the protein tyrosine phosphatase family, play important roles in physiology and pathophysiology as key regulators in signaling cascades. By investigating their involvement in diseases and pathologies, pseudophosphatases have emerged as potential therapeutic drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Christie L. Burton, Mathieu Lemire, Bowei Xiao, Elizabeth C. Corfield, Lauren Erdman, Janita Bralten, Geert Poelmans, Dongmei Yu, S-M Shaheen, Tara Goodale, Vanessa M. Sinopoli, Noam Soreni, Gregory L. Hanna, Kate D. Fitzgerald, David Rosenberg, Gerald Nestadt, Andrew D. Paterson, Lisa J. Strug, Russell J. Schachar, Jennifer Crosbie, Paul D. Arnold
Summary: The study investigated genetic variants associated with obsessive-compulsive (OC) traits and found shared genetic risk between OC traits and obsessive-compulsive disorder (OCD). The research identified a significant genetic variant for OC traits and demonstrated the feasibility of using trait-based approaches for genetic discovery in community samples.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Evan T. Liechty, Andrew Hren, Levi Kramer, Gregory Donovan, Anika J. Friedman, Michael R. Shirts, Jerome M. Fox
Summary: Neutral mutational drift is an important but underutilized source of biological diversity in protein biophysics. This study focuses on protein tyrosine phosphatase 1B (PTP1B) and investigates how neutral drift impacts its catalytic activity and stability. The findings suggest that neutral or mildly activating mutations can counteract deleterious ones, indicating a moderate activity-stability tradeoff. The study also shows that neutral mutations in allosterically influential sites are purged under biological selection, enriching for mutations outside of the active site.
Article
Biochemistry & Molecular Biology
Alessandra V. S. Faria, Bingting Yu, Michiel Mommersteeg, Patricia F. de Souza-Oliveira, Sheila S. Andrade, Manon C. W. Spaander, Moniek P. M. de Maat, Maikel P. Peppelenbosch, Carmen Ferreira-Halder, Gwenny M. Fuhler
Summary: LMWPTP, a member of the protein tyrosine phosphatase family, has been found to be overexpressed in cancer cells and to promote tumor cell proliferation through interaction with platelets. These findings suggest that LMWPTP may play a key role in driving oncogenic changes in tumor cells by enhancing their interaction with platelets.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Valerie Vinette, Isabelle Aubry, Hayley Insull, Noriko Uetani, Serge Hardy, Michel L. Tremblay
Summary: Metabolic reprogramming in cancer cells is regulated by tyrosine kinases and tyrosine phosphatases. Among the protein tyrosine phosphatase (PTP) superfamily, TC-PTP (PTPN2) has been identified as a key regulator of mitochondrial metabolism in cancer cells, with its inhibition resulting in functional defects in oxidative metabolism.
Review
Cell Biology
Caroline E. Nunes-Xavier, Laura Zaldumbide, Lorena Mosteiro, Ricardo Lopez-Almaraz, Nagore Garcia de Andoin, Pablo Aguirre, Maite Emaldi, Leire Torices, Jose I. Lopez, Rafael Pulido
Summary: Neuroblastoma is a type of cancer associated with early development and differentiation of neuroendocrine cells, and PTPs play a key role in cell growth and differentiation, potentially serving as biomarkers and molecular targets for neuroblastoma therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Deqiang Liu, Yiming Zhang, Hui Fang, Jinxiang Yuan, Lizhen Ji
Summary: Pseudophosphatases are a class of enzymes that mutate at the catalytically active site and play important roles in life processes and diseases. This review discusses the structures, action types, and signaling mechanisms of pseudophosphatases in various families.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Matteo Accorsi, Markus Tiemann, Leon Wehrhan, Lauren M. Finn, Ruben Cruz, Max Rautenberg, Franziska Emmerling, Joachim Heberle, Bettina G. Keller, Joerg Rademann
Summary: This study reports the discovery and investigation of pentafluorophosphato amino acids as novel phosphotyrosine biomimetics. Experimental and computational methods were used to demonstrate that these novel biomimetics have significantly enhanced binding affinity to the protein tyrosine phosphatase PTP1B, suggesting their potential value in drug molecule development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Microbiology
Aline Freville, Benedicte Gnangnon, Asma S. Khelifa, Mathieu Gissot, Jamal Khalife, Christine Pierrot
Summary: This review presents an overview of the diversity of phosphatases in Apicomplexan parasites and discusses their various functions throughout the parasites' life cycles. It also explores how this diversity can be utilized for the design of innovative and specific drugs/therapeutic strategies.
Article
Chemistry, Multidisciplinary
Johanna Schirmer, Ester Iatta, Aleksei V. Emelianov, Maija Nissinen, Mika Pettersson
Summary: Biosensors based on graphene and bio-graphene interfaces have gained popularity due to their excellent electronic and mechanical properties. This study investigates the catalytic activity of horseradish peroxidase immobilized on graphene surfaces with varying degrees of oxidation. The results show that the catalytic activity decreases with increasing oxidation, indicating surface-related effects on enzyme activity.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Biochemical Research Methods
Anna Serbina, Anthony C. Bishop
Summary: This study demonstrates the use of differential scanning fluorimetry as a rapid and quantitative method to measure the strength of SHP2 autoinhibition. This method does not require protein labeling or specialized instrumentation and is applicable for evaluating the autoinhibitory interactions in different SHP2 mutants.
ANALYTICAL BIOCHEMISTRY
(2023)