Article
Nutrition & Dietetics
Laura Tarancon-Diez, Miguel Genebat, Manuela Roman-Enry, Elena Vazquez-Alejo, Maria de la Sierra Espinar-Buitrago, Manuel Leal, Ma Angeles Munoz-Fernandez
Summary: This study aimed to determine a clinically relevant ferritin threshold to define absolute iron deficiency. The findings suggest that serum ferritin levels below 50 ng/mL are indicative of early iron deficiency.
Article
Nutrition & Dietetics
Sixtus Aguree, Arthur Owora, Misty Hawkins, Manju B. Reddy
Summary: Obesity is associated with health and nutritional problems, including impaired iron metabolism leading to anemia. We conducted a study to determine the prevalence of anemia, iron deficiency (ID), and iron deficiency anemia (IDA) in women aged 20-49 years based on body mass index (BMI). Analysis of data from the National Health and Nutrition Examination Survey (NHANES) showed higher levels of certain iron measures and lower levels of others in obese women compared to those with normal weight. The prevalence rates of ID and anemia (and IDA) were generally higher in obese women, but the choice of iron indices impacted the estimates.
Review
Nutrition & Dietetics
Marcin Delijewski, Aleksandra Barton, Beata Maksym, Natalia Pawlas
Summary: Iron is a crucial transition metal in physiological processes, but it can also be toxic due to its involvement in free radical formation. Impaired iron metabolism leads to iron deficiency, anemia, and iron overload, with different prevalences in transplant patients. Limited knowledge exists on iron metabolism in lung graft recipients and donors, complicated further by the potential impact of drugs. This overview highlights the importance of understanding iron turnover in transplant patients and assessing drug effects on iron metabolism for perioperative treatment in transplantology.
Article
Biochemistry & Molecular Biology
Hilde van der Staaij, Albertine E. Donker, Dirk L. Bakkeren, Jan M. J. I. Salemans, Lisette A. A. Mignot-Evers, Marlies Y. Bongers, Jeanne P. Dieleman, Tessel E. Galesloot, Coby M. Laarakkers, Siem M. Klaver, Dorine W. Swinkels
Summary: In this study, the TSAT/hepcidin ratio was found to be a useful tool for distinguishing IRIDA from IDA, with excellent performance in early diagnosis. This method helps identify IRIDA related to gene mutations, while recent iron therapy and moderate-to-severe inflammation should be excluded.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Reagan M. Mogire, John Muthii Muriuki, Alireza Morovat, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: There is a significant association between vitamin D and iron deficiency in African children. The risk of iron deficiency is increased in children with vitamin D deficiency, and vitamin D concentration variably influences iron status. Therefore, the link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies.
Article
Physiology
Yihang Li, Ian Miller, Princy Prasad, Nisha Ajit George, Nermi L. Parrow, Robert E. Fleming
Summary: This study investigates the role of transferrin in the erythropoietic response to iron deficiency and iron deficiency anemia. The results demonstrate that transferrin not only plays a role in iron delivery but also affects iron homeostasis and erythropoiesis. Administration of exogenous iron-loaded transferrin restores iron levels and influences the expression of regulatory proteins involved in erythropoiesis. In iron deficiency anemia, transferrin treatment increases erythropoietin sensitivity, highlighting its importance in the recovery from iron deficiency anemia.
FRONTIERS IN PHYSIOLOGY
(2022)
Letter
Medicine, General & Internal
Andrew J. Read, Akbar K. Waljee, Charity S. Chen, Robert Holleman, Kyle E. Kumbier, Sameer D. Saini
Summary: This cohort study examines the prevalence of appropriate testing for incident anemia in a large cohort from a national integrated health care system.
Article
Medicine, General & Internal
O. Yaw Addo, Emma X. Yu, Anne M. Williams, Melissa Fox Young, Andrea J. Sharma, Zuguo Mei, Nicholas J. Kassebaum, Maria Elena D. Jefferds, Parminder S. Suchdev
Summary: Anemia, characterized by low hemoglobin concentration, is a common blood condition worldwide. This study evaluated the WHO's Hb cutoffs for defining anemia among apparently healthy individuals and found that the proposed lower Hb cutoffs are statistically significant but also indicate compensatory increased erythropoiesis. Further research on clinical outcomes is needed to confirm the validity of these proposed Hb cutoffs.
Article
Gastroenterology & Hepatology
Heinz Zoller, Myles Wolf, Irina Blumenstein, Christian Primas, Stefan Lindgren, Lars L. Thomsen, Walter Reinisch, Tariq Iqbal
Summary: Despite comparable treatment efficacy for iron deficiency anaemia, FCM was associated with a higher incidence of hypophosphataemia compared to FDI. Further studies are needed to investigate the long-term clinical consequences of hypophosphataemia and the mechanisms underlying the differential effects of FCM and FDI on patient-reported fatigue.
Review
Biochemistry & Molecular Biology
Jolanta Artym, Michal Zimecki, Marian L. Kruzel
Summary: Pregnancy requires higher levels of nutrients, including iron, for the growth and maintenance of the fetus. Iron deficiency during pregnancy can lead to serious health issues, making iron supplementation essential for pregnant women. Studies suggest that lactoferrin can be an effective prophylaxis and treatment for iron deficiency anemia during pregnancy, offering various beneficial effects on iron homeostasis and overall health.
Article
Cardiac & Cardiovascular Systems
Fraser J. Graham, Pierpaolo Pellicori, Gabriele Masini, Joseph J. Cuthbert, Andrew L. Clark, John G. F. Cleland
Summary: This study explored the determinants of transferrin saturation (TSAT) in patients with heart failure, and the influence of serum transferrin concentration (STC) on TSAT and mortality. The results showed that lower STC (≤2.3 g/L) was associated with older age, lower iron concentration, lower hemoglobin, and higher inflammation markers. After adjusting for age, cardiac markers, and hemoglobin, both higher iron concentration and STC were negatively associated with mortality. These patients often have anemia and poor prognosis, but they are currently excluded from clinical trials of iron repletion.
Article
Medicine, General & Internal
Tatiana I. Ivanova, Ilya D. Klabukov, Ludmila I. Krikunova, Marina V. Poluektova, Natalia I. Sychenkova, Vera A. Khorokhorina, Nikolay V. Vorobyev, Margarita Ya. Gaas, Denis S. Baranovskii, Oksana S. Goryainova, Anastasiya M. Sachko, Peter V. Shegay, Andrey D. Kaprin, Sergei V. Tillib
Summary: This study evaluated the role of transferrin (Tf) in ovarian cancer (CrO) and related functional iron deficiency (FID), and found that Tf may be a promising tool for diagnosing both CrO and associated FID.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Jhanahan Sriranjan, Christine Kalata, Gerhard Fusch, Karen Thomas, Ipsita Goswami
Summary: This retrospective cohort study aimed to determine the characteristics of iron deficiency in extremely preterm neonates and its impact on neurodevelopmental outcomes at 18-24 months in the NICU. The study found that male infants and those treated with postnatal corticosteroids were more likely to have iron deficiency. However, low reticulocyte-hemoglobin levels during the neonatal period were not significantly associated with significant neurological disability in early childhood.
Article
Multidisciplinary Sciences
Chie Ogawa, Ken Tsuchiya, Naohisa Tomosugi, Kunimi Maeda
Summary: Our study found that Hb synthesis was maintained with lower TSAT and s-ft levels during Rox therapy compared to DA therapy. Ideal s-ft and TSAT levels before switching from DA to Rox to avoid iron deficiency during the 4 weeks after the switch were determined as 81.6 ng/mL and 23.9%, respectively.
Article
Nutrition & Dietetics
Vito Leonardo Miniello, Maria Carmen Verga, Andrea Miniello, Cristina Di Mauro, Lucia Diaferio, Ruggiero Francavilla
Summary: The complementary feeding period between 6 and 24 months is crucial for infant nutrition and development, especially in addressing iron deficiency and anemia. Healthcare providers should follow guidelines to ensure adequate iron intake and address iron deficiency in infants during this critical period.