Article
Biochemistry & Molecular Biology
Chiou-Mei Lee, Ming-Ling Chang, Ren-Hao Chen, Fan-Wen Chen, Jo-Chuan Liu, Shun-Li Kuo, Hsin-Hsin Peng
Summary: This study demonstrates that thrombin-activated platelets (TAPLT) can protect endothelial cells against tumor-related pro-inflammatory changes, inhibiting angiogenesis and metastasis. The protection is likely mediated by VCAM-1-mediated endothelial cell linkage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Sara Pastorino, Sara Baldassari, Giorgia Ailuno, Guendalina Zuccari, Giuliana Drava, Andrea Petretto, Vanessa Cossu, Cecilia Marini, Silvana Alfei, Tullio Florio, Gianmario Sambuceti, Gabriele Caviglioli
Summary: Atherosclerosis is a chronic progressive disease involving VCAM-1 overexpression. New PET radiopharmaceuticals MacroP and NAMP, based on VCAM-1 binding peptide, show high radiochemical purity and potential for early atheroma detection. NAMP also demonstrates higher radioactive uptake in vitro and may have future applications in theranostics.
Article
Immunology
Hye Won Jun, Hong Kyung Lee, Ik Ho Na, Su Jeong Lee, Kihyeon Kim, Geuno Park, Hyung Sook Kim, Dong Ju Son, Youngsoo Kim, Jin Tae Hong, Sang-Bae Han
Summary: This study examined the role of endothelial cells in the homing of natural killer (NK) cells to solid tumors. It was found that TNF-α and IL-1β activated endothelial cells, which increased NK cell migration and adhesion to the endothelial cells through the production of CCL2 and CCL7, as well as the upregulation of ICAM-1 and VCAM-1 expression on the endothelial cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qian Zhang, Wei Zhang, Jing Liu, Haisen Yang, Yuxia Hu, Mengdi Zhang, Tuya Bai, Fuhou Chang
Summary: The study investigated the regulatory role of LPC on endothelial cell adhesion marker expression, suggesting that the LPC-G2A-ICAM-1/VCAM-1 pathway may contribute to atherogenic activity of oxLDL, with NF-kappa B antagonists potentially serving as effective therapeutic tools for cardiovascular diseases.
Article
Clinical Neurology
Michael Auer, Angelika Bauer, Antonia Oftring, Dagmar Rudzki, Harald Hegen, Gabriel Bsteh, Franziska Di Pauli, Klaus Berek, Anne Zinganell, Thomas Berger, Markus Reindl, Florian Deisenhammer
Summary: Soluble vascular cell adhesion molecule 1 is a suitable pharmacodynamic marker during treatment with NTZ, which is significantly reduced already after the first dose, remains stable in individual patients even on extended interval dosing, and strongly correlates with NTZ SC. However, absolute levels of sVCAM-1 and NTZ SC are difficult to introduce as treatment monitoring biomarkers to predict disease activity in single patients.
Article
Medicine, General & Internal
Federico Carbone, Stefano Ministrini, Aldo Bonaventura, Alessandra Vecchie, Silvia Minetti, Nicholas Bardi, Edoardo Elia, Anna Maria Ansaldo, Daniele Ferrara, Erika Rijavec, Maria Giovanna Dal Bello, Federico Biello, Giovanni Rossi, Marco Tagliamento, Angela Alama, Simona Coco, Paolo Spallarossa, Francesco Grossi, Carlo Genova, Fabrizio Montecucco
Summary: This study found that high baseline serum levels of VCAM-1 in NSCLC patients are associated with longer survival when treated with nivolumab, and the change in VCAM-1 levels during treatment is an independent predictor of overall survival.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Ahmad Ghasemi, Golnaz Vaseghi, Alaei Hojjatallah, Shaghayegh Haghjooy Javanmard
Summary: This study found that morphine can affect the expression of VCAM-1 in lung cancer cell lines through the TLR4 pathway.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Carl G. Gahmberg, Mikaela Gronholm
Summary: Cell adhesion is crucial for organ formation, cellular migration, and interaction with target cells and the extracellular matrix. Recent research has revealed the role of integrin phosphorylations in regulating integrin activity and downstream signaling. The SARS-CoV-2 virus receptor ACE2 and potential integrin co-receptors may interact and induce phosphorylation switches and autophagy.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Article
Neurosciences
Kun Leng, Indigo V. L. Rose, Hyosung Kim, Wenlong Xia, Wilber Romero-Fernandez, Brendan Rooney, Mark Koontz, Emmy Li, Yan Ao, Shinong Wang, Mitchell Krawczyk, Julia Tcw, Alison Goate, Ye Zhang, Erik M. Ullian, Michael Sofroniew, Stephen P. J. Fancy, Matthew S. Schrag, Ethan S. Lippmann, Martin Kampmann
Summary: This study used CRISPR interference screening and single-cell transcriptomics to systematically investigate cytokine-induced inflammatory astrocyte reactivity. The researchers identified two distinct inflammatory reactive signatures regulated by STAT3, which were found to be overlapping with markers observed in other contexts and human diseases.
NATURE NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Yongqin Jiang, Lei Zhang, Huiyu Tian
Summary: This study investigated the role of miR-149 in osteoarthritis (OA) by inhibiting VCAM-1 and the PI3K/AKT pathway. The results showed that up-regulated miR-149 and suppressed VCAM-1 can alleviate inflammation and apoptosis caused by OA.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jia Guo, Zeyu Xu, Rachel C. Gunderson, Baohui Xu, Sara A. Michie
Summary: In this study, the researchers found that ICAM-1 is expressed on the sinus endothelia of lymph nodes, but not on the lymphatic vessels of peripheral tissues. Memory CD4(+) T cells migrated to lymph nodes from peripheral tissues more efficiently than from blood vessels. ICAM-1 deficiency significantly inhibited the migration of lymphocytes from peripheral tissues into lymph nodes, and the absence of ICAM-1 or LFA-1 reduced the number of memory T cells in lymph nodes.
Article
Geriatrics & Gerontology
Wen Deng, Caijiao Yi, Wei Pan, Jian Liu, Jinyan Qi, Juan Chen, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Changhua Ye, Zhongping Chen, Heping Xu
Summary: In patients with nAMD, levels of VCAM-1 were significantly elevated in those with macular fibrosis and correlated with retinal thickness. VCAM-1 was highly expressed at the site of fibrosis in a mouse model. Blocking VCAM-1 prevented macrophage infiltration and reduced subretinal fibrosis. VCAM-1 induced macrophage migration and influenced the expression of various genes involved in fibrosis.
Article
Immunology
Jae-Young Park, Hyo-Min Park, Seonhwa Kim, Kyeong-Bae Jeon, Chae-Min Lim, Jin Tae Hong, Do-Young Yoon
Summary: IL-32 theta A94V, a mutant isoform, can inhibit monocyte-endothelial adhesion by binding to integrins aVb3 and aVb6, thus reducing the early step of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Keiichiro Mori, Victor M. Schuettfort, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Nico C. Grossmann, Pawel Rajwa, Jeremy Yc Teoh, Irene Resch, Harun Fajkovic, Marco Moschini, David D'andrea, Mohammad Abufaraj, Pierre Karakiewicz, Yair Lotan, Douglas Scherr, Shin Egawa, Eva Comperat, Shahrokh F. Shariat
Summary: Elevated plasma VCAM-1 levels are associated with aggressive UCB disease features and can be used as a biomarker to identify patients who may benefit from intensified/multimodal therapy. Adding VCAM-1 to predictive models significantly improves their discriminatory ability. VCAM-1 can also be used to refine personalized clinical decision-making.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meghan E. Fallon, Monica T. Hinds
Summary: Endothelial cell morphology and cytoskeletal alignment play a significant role in regulating VCAM-1 protein expression, with elongated cells and aligned cytoskeleton downregulating VCAM-1 expression in the absence of hemodynamic effects. Actin alignment has a stronger effect on VCAM-1 expression than cell elongation, and VCAM-1-dependent adhesion of monocytic cells is reduced on micropatterns compared to planar substrates.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)