Article
Chemistry, Analytical
M. Shivakumar, S. Manjunatha, K. N. Nithyayini, M. S. Dharmaprakash, K. L. Nagashree
Summary: NiCo2O4 nanotapes were synthesized through a facile method without structure directing agents, showing crystalline phase purity and high surface area. The nanostructures exhibited catalytic activity towards nitrite oxidation in phosphate buffer, with fast electron transfer and good electrochemical detection performance.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
G. Massimo, R. S. Khambata, T. Chapman, K. Birchall, C. Raimondi, A. Shabbir, Nicki Dyson, K. S. Rathod, C. Borghi, A. Ahluwalia
Summary: XDH mutations have varying impacts on the biochemical activity of the enzyme, leading to potential harmful or protective influences on health. Targeting enzyme activity to enhance the nitrite-reductase profile may provide novel therapeutic options, especially in cardiovascular disease.
Article
Microbiology
Barbara Schmidinger, Kristina Petri, Clara Lettl, Hong Li, Sukumar Namineni, Hellen Ishikawa-Ankerhold, Luisa Fernanda Jimenez-Soto, Rainer Haas
Summary: This study reveals an interaction between Helicobacter pylori and human annexins, which may help the bacterium evade recognition by the host innate immune system.
Article
Chemistry, Multidisciplinary
Annu Kumari, Wim Dehaen, Deepak Chopra, Swapan Dey
Summary: Convenient and straightforward methods have been developed for the detection and quantitative estimation of fluoride anions using two novel imidazopyridine-based carboxamides (C1 and C2) in organic and aqueous media. These molecules exhibit high selectivity and enhanced sensitivity towards recognizing fluoride ions through a fluorogenic mode. The deprotonation of the N-H proton driven by fluoride ions and its subsequent spectral changes have been characterized using H-1 and F-19 NMR spectroscopy. The structures of the carboxamides and the resulting deprotonated carboxamide salts have been confirmed using single-crystal X-ray diffraction.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ylana Adami Franco, Manoel Oliveira de Moraes Jr, Larissa A. C. Carvalho, Wolfgang Dohle, Renaira Oliveira da Silva, Isabella Harumi Yonehara Noma, Keli Lima, Barry V. L. Potter, Joao A. Machado-Neto, Silvya Stuchi Maria-Engler
Summary: The sulfamoylated derivative of endogenous estradiol, STX140, shows superior potential as a therapeutic agent for melanoma treatment. It inhibits cell proliferation, induces cell cycle arrest and apoptosis, reduces migration and clonogenic potential, and inhibits invasion in melanoma cells. Furthermore, STX140 induces senescence features and activates the senescence machinery in melanoma cells. These findings suggest that STX140 may be a promising candidate for melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Chaonan Huang, Jiajia Yang, Jiping Ma, Weiqiang Tan, Lingxia Wu, Bin Shan, Shasha Wang, Jiping Chen, Yun Li
Summary: In this study, a novel PDVB-QPEI MAX adsorbent was developed and demonstrated excellent extraction and cleanup efficiency for bisphenol analogues and MPEs in urine samples. The adsorbent exhibited high ion-exchange capacity and selectivity, making it suitable for the analysis of these compounds in complex samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Sergio E. Dominguez, Antti Vuolle, Alberto Fattori, Timo Aaritalo, Michela Cangiotti, Pia Damlin, M. Francesca Ottaviani, Carita Kvarnstrom
Summary: This study investigates the effect of O-alkylation proximity on the hydrogen bonding capabilities of alkoxy-CPTs. The results show that a closer proximity of O-alkylation strengthens the hydrogen bonding capabilities of the CPTs. The study also highlights the influence of solvent conditions and side chain lengths on the morphology and surface free energy of the CPTs.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Su-Jung Kim, Nam-Chul Cho, Bitnara Han, Kyeojin Kim, Young-Il Hahn, Kwang Pyo Kim, Young Ger Suh, Bu Young Choi, Hye-Kyung Na, Young-Joon Surh
Summary: The cyclopentenone prostaglandin 15d-PGJ2 functions as an allosteric inhibitor of STAT3 by covalently modifying STAT3 on Cys259, inhibiting its activity in MCF10A-Ras cells. This results in antiproliferative and pro-apoptotic effects similar to mutation of this amino acid.
Article
Biochemistry & Molecular Biology
Ji-Hye Jang, Min-Seong Kim, Ainsley Mike Antao, Won-Jun Jo, Hyung-Joon Kim, Su-Jin Kim, Myeong-Jun Choi, Suresh Ramakrishna, Kye-Seong Kim
Summary: This study identified O-cyclic phytosphingosine-1-phosphate (cP1P) as a novel factor that significantly enhances the differentiation potential of human embryonic stem cells (hESCs) into cardiomyocytes. Treatment with cP1P was found to increase the beating colony number and contracting area of cardiomyocytes. Furthermore, the molecular mechanism of cP1P regulating SMAD1/5/8 signaling via the ALK3/BMP receptor cascade during cardiac differentiation was elucidated. The results provide a new insight for using cP1P to improve the quality of cardiomyocyte differentiation for regenerative therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Automation & Control Systems
Xiaojie Su, Fandi Qing, Hongbin Chang, Shuoyu Wang
Summary: This article investigates the tracking problem of the adaptive sliding-mode control (SMC) design for human support robots based on a disturbance observer. A finite-time controller using nonsingular fast terminal SMC is proposed, and a robust disturbance observer is developed to estimate system uncertainties and disturbances. An adaptive control technology is developed to deal with the unknown bounded disturbance observer error. The simulations demonstrate that human support robots employing the proposed controller can converge to the desired trajectory.
IEEE TRANSACTIONS ON CYBERNETICS
(2023)
Article
Materials Science, Multidisciplinary
Shuqiang Zhao, Peixiao Zheng, Qing Liu, Li Niu, Honglian Cong, Ailan Wan
Summary: This study successfully fabricated a strain sensor with laminated structure containing multiple composite layers, demonstrating stable performance under various strain ranges, excellent electrical conductivity, and outstanding durability. It is suitable for applications such as human motion detection and temperature sensing.
MATERIALS & DESIGN
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yujie Hu, Chengjia You, Chenghao Song, Yu Shi, Ling Ye
Summary: The study revealed that O-GlcNAcylation modification is involved in regulating the differentiation and mineralization of dental pulp cells, playing a crucial role in the mTORC1 pathway, and the O-GlcNAc modification of RAPTOR is essential for inducing odontogenesis.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Genetics & Heredity
Barbara Ramsak, Jessica Markau, Tobias Pazen, Tim A. Dahlmann, Sven Krappmann, Ulrich Kueck
Summary: The DNA-binding sequence of the MAT1-1-1 transcription factor from Aspergillus fumigatus was identified and characterized. The study explored MAT1-1-1 DNA-binding targets, revealing insights into gene expression regulation in fungi through the alpha-box domain regulators. The specific DNA-binding specificity and affinity were confirmed through mutational analysis and equilibrium dissociation constant determination.
G3-GENES GENOMES GENETICS
(2021)
Article
Chemistry, Analytical
Lukas C. Harps, Daniel A. Bizjak, Ulrich Girreser, Martina Zuegel, Juergen M. Steinacker, Patrick Diel, Maria Kristina Parr
Summary: In this study, the quantitation of formoterol, salbutamol, and its phase II metabolite salbutamol-4'-O-sulfate in urine and serum samples using ultra-high performance liquid chromatography-tandem mass spectrometry was successfully demonstrated. The highest concentrations of formoterol, salbutamol, and salbutamol-4'-O-sulfate in serum were found to be 14.2 pg/mL, 10.0 ng/mL, and 21.4 ng/mL, respectively, while in urine (after deglucuronidation), the maximum concentrations were 17.2 ng/mL, 948.5 ng/mL, and 2738.5 ng/mL, respectively. Sex-specific differences were also observed in serum concentrations and urinary excretion. These results highlight the importance of including and elucidating phase II metabolites in quantitation methods for antidoping.
Article
Pharmacology & Pharmacy
Baogang Tian, Zhen Hua, Zhijiong Wang, Jianwei Wang
Summary: The study found that PG has anti-tumor effects on cell pyroptosis and metastasis in human osteosarcoma cells, possibly mediated by the ER stress-activated NLRP3 inflammasome. In addition, PG also reduced tumor growth and invasion in a xenograft osteosarcoma mouse model.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
