Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 27, Issue 3, Pages 247-262Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2015.1120474
Keywords
Electrospinning; polyvinyl alcohol; polyvinyl pyrrolidone; wound dressings; antimicrobial; cell affinity
Funding
- Department of Atomic Energy [2010/34/54/BRNS]
- Department of Biotechnology [BT/505/NE/TBP/2013, BT/IN/Sweden/38/BBM/2013]
- Department of Science and Technology, Government of India [SB/FT/LS-213/2012]
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Cross-linked polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) composite nanofibrous membranes have been prepared by electrospinning. Mechanical properties of the membranes improved significantly with PVP addition. PVP improved hydrophilicity and sustainable degradation of the membranes. Biocompatibility of the membranes was assessed by in vitro culture of native skin cells (L929 fibroblast and HaCaT keratinocytes). Tests showed sustained release of the antibiotic ciprofloxacin hydrochloride monohydrate by the membranes. Further, zone of inhibition study against Staphylococcus aureus growth demonstrated protective action against external pathogenic microbes. These studies show these simple PVA-PVP nanofibrous membranes are promising interactive antibiotic-eluting wound dressing materials.
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