Article
Plant Sciences
Akane Kasei, Hanako Watanabe, Natsumi Ishiduka, Kyoko Noda, Masatsune Murata, Masaaki Sakuta
Summary: A variety of compounds in plants are synthesized by specialized metabolic enzymes. Betalains have replaced anthocyanins in most Caryophyllales families. The enzyme DOD, coded by LigB genes, plays a key role in betalain biosynthesis and has homologs in a wide range of higher plants, fungi, and bacteria.
PLANT AND CELL PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiang-Zhu Wei, Tian-Yu Ding, Yang Wang, Bing Yang, Qing-Qing Yang, Shengfa Ye, Chen-Ho Tung, Li-Zhu Wu
Summary: In this work, an electron-rich and oxidation-resistant ligand was introduced to stabilize high-valent iron-oxo species for water oxidation reactions. Advanced spectroscopies and electrochemical studies revealed the formation of a high-valent Fe-V(O) species in water. Kinetic and oxygen isotope labelling experiments, along with organic reactions, demonstrated that the Fe-V(O) species is responsible for O-O bond formation via water nucleophilic attack under real catalytic water oxidation conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Ji-Jia Zhou, Ya-Nan Meng, Li-Gao Liu, Yi-Xi Liu, Zhou Xu, Xin Lu, Bo Zhou, Long-Wu Ye
Summary: The functionalization of etheric C-O bonds via C-O bond cleavage is a promising method for the synthesis of C-C and C-X bonds. However, the enantioselective version of these reactions, mainly involving C(sp(3))-O bond cleavage, is highly challenging. Here, we present a copper-catalyzed asymmetric cascade cyclization, which allows for the efficient and enantioselective synthesis of chromeno[3,4-c]pyrroles with a triaryl oxa-quaternary carbon stereocenter. Notably, this protocol represents the first example of [1,2]-Stevens-type rearrangement via C(sp(2))-O bond cleavage and [1,2]-aryl migration reactions via vinyl cations.
Article
Chemistry, Physical
Yang Sik Yun, Claudia E. Berdugo-Diaz, David W. Flaherty
Summary: Biomass has received considerable attention as an alternative to petrochemicals in the production of valuable chemicals and fuels. This Perspective discusses significant advancements in understanding the reaction networks and mechanisms, reactive intermediates, and active site motifs for selective production of desired compounds through hydrogenolysis over heterogeneous catalysts. Continuing research into hydrogenolysis reactions faces current challenges and provides opportunities for future exploration.
Article
Biotechnology & Applied Microbiology
Hamdy A. Hassan, Marina d'Enza, Jean Armengaud, Dietmar H. Pieper
Summary: A study on Rhizorhabdus wittichii RW1 found that four extradiol dioxygenases identified in this bacteria showed activity in degrading a range of aromatic compounds. Among them, Edo4 enzyme demonstrated the best degradation efficiency, while Edo3 enzyme did not experience mechanism-based inactivation, making it a suitable candidate for chlorobiphenyl degradation.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Ding Ma, Naifeng Hu, Junli Ao, Shaoli Zang, Guo Yu, Guangxin Liang
Summary: Pauson-Khand reactions with concomitant C-O bond cleavage have been developed for constructing complex bicyclic ring systems with precise control over regio- and stereochemistry. The mechanism behind this reaction has been proposed based on deuterium labelling experiments.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Physical
Dongxiang Wu, Yaguang Zhu, Weitao Shan, Jianyu Wang, Qianqian Liu, Guangwen Zhou
Summary: This study reports the formation of a metastable Cu-O/OH superstructure during the reaction of hydrogen with oxygen-covered Cu(110) and elucidates the reaction pathways leading to its formation. These findings reveal the complex surface dynamics resulting from parallel reaction pathways and suggest the possibility of directing the reaction dynamics by manipulating transient surface structure and composition.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Panu Pimviriyakul, Supacha Buttranon, Sahachat Soithongcharoen, Cheerapat Supawatkon, Kasidis Disayabootr, Pratchaya Watthaisong, Ruchanok Tinikul, Aritsara Jaruwat, Pimchai Chaiyen, Penchit Chitnumsub, Somchart Maenpuen
Summary: This study reports the structure and biochemical properties of DHPAO from Acinetobacter baumannii. The 3D structure of the enzyme is different from other known DHPAOs, but shares a similar chemical reaction mechanism. The enzyme was found to not only catalyze the degradation of DHPA, but also use other similar compounds as substrates, albeit with low reactivity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Ana Amic, Dejan Milenkovic, Zoran Markovic, Denisa Cagardova, Jaime Rodriguez-Guerra Pedregal, Jasmina M. Dimitric Markovic
Summary: The kinetics and thermodynamics of phenolic O-H and C-ring C-H bond breaking in dihydrokaempferol, a natural flavonoid compound, were investigated using a density functional based approach. The study found that the 4'-OH phenolic hydrogen is involved in the inactivation of a hydroperoxyl radical (OOH), while the hydrogen atom transfer mechanism is responsible for C-H bond cleavage.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Angelika Rafalowski, Bakar A. Hassan, Kate Lou, Minh Chau Nguyen, Erika A. Taylor
Summary: This study investigated the importance of position 103a at the dimer interface of LigAB through experimental and computational simulations. The results revealed a preference for nonpolar/aromatic amino acids at this position to maintain the integrity of the heterodimer. Understanding the dimerization of LigAB provides insights for uncharacterized multimeric proteins and considerations for engineering proteins that can efficiently degrade lignin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Yaxuan Jing, Mohsen Shakouri, Xiaohui Liu, Yongfeng Hu, Yong Guo, Yanqin Wang
Summary: Researchers have developed a strategy to selectively cleave C-C bonds in aromatic plastics using catalyst Ru/Nb2O5 through methanol poisoning, resulting in monocyclic phenolic compounds.
Article
Chemistry, Multidisciplinary
Le Jia, Chao-Jun Li, Huiying Zeng
Summary: Lignin, as a component of lignocellulosic biomass, poses a great challenge for degradation and utilization due to its strong and stable linkages. A cleavage/cross-coupling strategy has been developed to convert lignin model compounds into high value-added compounds. This study presents a palladium-catalyzed cleavage/cross-coupling reaction for the preparation of benzyl amine compounds and phenols through dual C-O bond cleavage.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Lasien D. Rymbai, Kevin K. Klausmeyer, Patrick J. Farmer
Summary: This study reveals that quercetin dioxygenases (QDOs) can catalyze ring-opening reactions with dioxygen by generating oxidopyrylium emissive states. This finding has important implications for understanding the mechanism of dioxygenases.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Yue Liu, Wei Zhang, Cong Hao, Shuai Wang, Haichao Liu
Summary: Converting naturally occurring sugars into fuels and chemicals offers a sustainable and carbon-neutral alternative to fossil resource-based processes. Tungsten-based catalysts are efficient in selectively breaking the C-C bonds of sugars, producing oxygenate intermediates that can be used in the synthesis of various chemicals. This research reveals the mechanism of sugar conversion and provides insights for the rational design of catalytic sites and reaction pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Christopher E. Rivas, Jose C. Alvarado-Monzon, Gerardo Gonzalez-Garcia, J. Oscar C. Jimenez-Halla, Jesus Rangel-Garcia, Crispin Cristobal, Jorge A. Lopez
Summary: The study presents the synthesis of complexes 1 and 2 through oxidative coordination and cleavage of C-3-C(O)Me bond of L1. Plausible mechanisms for the reactions leading to the formation of complexes 1 and 2 are proposed using DFT calculations.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Food Science & Technology
Osman N. Kanwugu, Tatiana Glukhareva, Irina G. Danilova, Elena G. Kovaleva
Summary: Diabetes is a major health emergency worldwide, affecting millions of people. Oxidative stress and inflammation play key roles in the development of diabetes and its complications. Astaxanthin, a powerful antioxidant found in marine organisms, has shown potential benefits in the treatment and management of diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Saied A. Aboushanab, Shaimaa M. Khedr, Irina F. Gette, Irina G. Danilova, Natalia A. Kolberg, Gokare A. Ravishankar, Ranga Rao Ambati, Elena G. Kovaleva
Summary: Isoflavones, the most abundant category of plant polyphenols, have demonstrated health benefits but studies remain variable and controversial, requiring further standardized analysis to explore their potential therapeutic effects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Jason C. Jones, Rahul Banerjee, Manny M. Semonis, Ke Shi, Hideki Aihara, John D. Lipscomb
Summary: The activity of soluble methane monooxygenase (sMMO) relies on the formation of a complex between the regulatory protein MMOB and the (alpha beta gamma)(2) hydroxylase alpha subunit. Mutations in MMOB can dramatically impact the rate constants for steps in the sMMOH reaction cycle, as revealed in X-ray crystal structures of sMMOH complexes with various variants of MMOB. Different variants alter the formation rate of reaction cycle intermediates and the position of key residues, ultimately affecting sMMO catalysis efficiency.
Review
Chemistry, Multidisciplinary
Qinglin Yang, Weiwei Xu, Ming Cheng, Siyun Zhang, Elena G. Kovaleva, Feng Liang, Demei Tian, Jun-an Liu, Reda M. Abdelhameed, Jing Cheng, Haibing Li
Summary: This feature article summarizes the advances in stimuli-responsive pillararene modified nanosystems for controlled drug release, including decomposition release and gated release. The control principles of these nanosystems are discussed in detail.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Asmaa M. Abu El-Soad, Giuseppe Lazzara, Mahmoud O. Abd El-Magied, Giuseppe Cavallaro, Jamelah S. Al-Otaibi, M. I. Sayyed, Elena G. Kovaleva
Summary: This study tested the adsorption characteristics of carboxyl group modified chitosan (CTS-CAA) towards copper (II) and zinc (II) ions, and characterized the modified chitosan using various techniques. The results showed that CTS-CAA had good adsorption capacity for Cu (II) and Zn (II), and exhibited favorable adsorption kinetics and thermodynamics under variable conditions. Moreover, CTS-CAA could be regenerated using different eluents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Christabel Nutakor, Osman N. Kanwugu, Elena G. Kovaleva, Tatiana V. Glukhareva
Summary: Astaxanthin is a valuable ketocarotenoid with significant biological activities and economic value. Microbial production of natural astaxanthin has gained attention recently due to its applications in various industries. While productivity is currently limited, microbial production shows great potential as a sustainable and greener alternative. Phaffia rhodozyma, a yeast capable of utilizing agro-food waste, has been studied for its potential in natural astaxanthin production. Phytohormones have shown promising results in improving astaxanthin yield in yeast and algae, although research in P. rhodozyma is limited. Further studies have reported positive effects of phytohormones on carotenogenesis genes expression in this yeast.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Plant Sciences
Saied A. Aboushanab, Vadim A. Shevyrin, Grigory P. Slesarev, Vsevolod V. Melekhin, Anna Shcheglova, Oleg G. Makeev, Elena G. Kovaleva, Ki Hyun Kim
Summary: Pediatric solid tumors pose a threat to children's health, and soy and kudzu root extracts have been found to have antioxidant and cytotoxic effects, making them potential alternatives for treating these tumors.
Article
Agricultural Engineering
Kingsley C. Duru, Grigory P. Slesarev, Saied A. Aboushanab, Igor S. Kovalev, David M. Zeidler, Elena G. Kovaleva, Rajeev Bhat
Summary: The extraction efficiency, recovery, quantification, and stability of isoflavones from kudzu roots and soy molasses wastes/by-products were evaluated using natural deep eutectic solvents (NADESs) and ultrasound-assisted extraction. Results showed that NADES extraction significantly increased the extractability of puerarin and exhibited higher antioxidant activity and reduced degradation of isoflavones compared to conventional extraction techniques.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Nuclear Science & Technology
K. A. Mahmoud, A. M. Abu El-Soad, E. G. Kovaleva, Nouf Almousa, M. I. Sayyed, O. L. Tashlykov
Summary: This work aims to improve the shielding properties of liquid radioactive waste containers used in nuclear power plants for cooling water treatments. The proposed container, with increased thickness of the inner capsule and filler, can significantly reduce the equivalent dose rate. It also has other advantages.
PROGRESS IN NUCLEAR ENERGY
(2022)
Article
Biochemistry & Molecular Biology
Melanie S. Rogers, Adrian M. Gordon, Todd M. Rappe, Jason D. Goodpaster, John D. Lipscomb
Summary: This study found that both hydroxylation and methyl hydroxylation of salicylate are catalyzed by monooxygenase chemistry. The functional unit involved in these reactions consists of a nonheme Fe(II) site and a Riesketype iron-sulfur cluster. Fluorine ring substituents were found to decrease the rate of Rieske electron transfer, suggesting a reaction between an Fe(III)-superoxo intermediate and the substrate. It was also discovered that both aromatic and aryl-methyl hydroxylation reactions start with the reaction of Fe(III)-superoxo with a ring carbon, but the latter must be reversible to yield a normal product isotope effect.
Article
Biochemistry & Molecular Biology
Alexander Strom, Rachit Shah, Rafal Dolot, Melanie S. Rogers, Cher-Ling Tong, David Wang, Youlin Xia, John D. Lipscomb, Carston R. Wagner
Summary: Human histidine triad nucleotide-binding proteins play important roles in the activation of antiviral proTides. Different subtypes of these proteins have different functions. Our study reveals that changes in surface residues can affect the function of the proteins.
Article
Physics, Atomic, Molecular & Chemical
D. R. Davydov, D. O. Antonov, E. G. Kovaleva
Summary: This research applies and compares the most popular machine learning algorithms (multilayer perceptron, ensemble of networks, convolutional neural network) to predict the shape of dynamic EPR signals of pH-sensitive nitroxide radicals. The results show that the multilayer perceptron and ensemble of networks have good accuracy in predicting signal shapes within a narrow scope, while the convolutional neural network performs the worst. These findings can be useful for developing software design to estimate the parameters of analyzed systems quickly based on EPR spectra.
APPLIED MAGNETIC RESONANCE
(2023)
Article
Food Science & Technology
Justice A. Essiedu, Parise Adadi, Elena G. Kovaleva
Summary: This study evaluated the effect of Hibiscus sabdariffa calyces on the fermentation kinetics, phytochemical constituents, volatile organic compounds, and sensory profile of beer. The results showed that the supplementation of Hibiscus sabdariffa did not alter the fermentation process but increased the polyphenol content and antioxidant activity of the beer.
Article
Biotechnology & Applied Microbiology
Queency N. Okechukwu, Parise Adadi, Elena G. Kovaleva
Summary: This study evaluated the effects of Chlorella vulgaris powder on fermentation parameters, sensory perception, phytochemical compounds, antioxidant activity, and volatile organic compounds in treated beers. The results showed that the addition of Chlorella vulgaris increased the concentration of polyphenols, flavonoids, and antioxidant activity in the treated beers. However, it had no significant effects on higher alcohols and sensory perception. Therefore, Chlorella vulgaris could be used as a potential ingredient for designing functional beers.
FERMENTATION-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Yu Li, Wenjie Li, Weiwei Xu, Jinmei Huang, Zhongyue Sun, Tangbin Liao, Elena G. Kovaleva, Chuanlai Xu, Jing Cheng, Haibing Li
Summary: In this study, glycine-pillar[6]arene (Gly-P6)-functionalized tapered nanochannels were used to selectively transport nucleic acids, overcoming the challenges in extracting high-purity nucleic acids from complex biological samples.
CHEMICAL COMMUNICATIONS
(2022)
