Article
Polymer Science
Yang Yang, Zixun Wang, Yuanyuan Xu, Jingjing Xia, Zhaoxian Xu, Shuai Zhu, Mingjie Jin
Summary: This study developed novel photo-responsive bioinks for 3D bioprinting using reliable Type-III recombinant human collagen and chitosan. The addition of chitosan allowed for tunable mechanical properties and degradation of the bioinks. In vitro tests confirmed the biocompatibility of these bioinks and their potential in constructing different tissues through 3D bioprinting.
Article
Engineering, Chemical
Shanthi Shriram, S. V. Aruna Rani, Selvakumar Kritika, Saravana Karthikeyan Balasubramanian, Kothandaraman Rajkumar, Sekar Mahalaxmi
Summary: This study aimed to evaluate the effects of PHS and PAC on cell viability, flexural strength, and depth of penetration following surface pretreatment of demineralized dentin. Results indicate that PHS may be a promising alternative to PAC in this application.
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Rory Gibney, Jennifer Patterson, Eleonora Ferraris
Summary: Research has successfully demonstrated the production of bioprinted recombinant collagen films suitable for corneal tissue engineering using aerosol jet printing technology, showing favorable mechanical and optical properties.
Article
Dentistry, Oral Surgery & Medicine
Yi Zhou, Yuming Zhao, Jianmin Han
Summary: This study compared the bonding effects of EDTA-chitosan, phosphoric acid, and SE-Bond. Through a series of experiments, it was found that EDTA-chitosan can extrafibrillarly demineralize collagen fibers, provide better bonding strength and durability compared to phosphoric acid wet bonding, and has lower cytotoxicity.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Qiang Yang, Jing Guo, Sen Zhang, Fucheng Guan, Yue Yu, Shi Feng, Xuecui Song, Da Bao, Xin Zhang
Summary: In this study, PVA/PEO/CHI nanofiber scaffolds were successfully prepared by incorporating chitosan into the PVA/PEO system. These scaffolds exhibited a hierarchical pore structure and elevated porosity, providing suitable space for cell growth. The addition of CHI effectively improved cell adhesion and surface wettability of the nanofiber scaffolds, and increased the breaking stress and mechanical properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Chenglu Liu, Lihua Fu, Tao Jiang, Yufeng Liang, Yen Wei
Summary: By incorporating acrylic acid-modified bentonite into the cross-link network, an organic-inorganic cross-linked self-healing hydrogel with excellent mechanical properties was developed. The hybrid network showed high tensile strength, compressive modulus, and elongation at break, with the formation of hydrogen bonds between the polymer chains. Additionally, the hydrogel exhibited outstanding self-healing properties with a high rate of stress and strain recovery after 4 hours.
Article
Chemistry, Medicinal
Shuilin Cai, Nan Pan, Min Xu, Yongchang Su, Kun Qiao, Bei Chen, Bingde Zheng, Meitian Xiao, Zhiyu Liu
Summary: The study identified an ACE inhibitory peptide, FNLRMQ, from Takifugu bimaculatus, which showed potential antihypertensive effects by regulating the Nrf2/HO-1 and PI3K/Akt/eNOS signaling pathways to protect endothelial injury induced by Ang-II. This peptide could be a potential candidate compound for antihypertensive treatment and highlights the high-value utilization of marine resources like T. bimaculatus.
Article
Biotechnology & Applied Microbiology
Yunqing Dong, Weidong Zhu, Xiaoxuan Lei, Xin Luo, Qi Xiang, Xuanru Zhu, Qiao Pan, Panshi Jin, Biao Cheng
Summary: This study confirmed that recombinant human-like collagen and recombinant human-like fibronectin can effectively promote the proliferation, migration, and adhesion of fibroblast cells, and improve the healing speed and quality of acute wounds. The combination of the two proteins showed better results than individual treatments, indicating potential applications in the field of skin repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Muzhou Teng, Zhijia Li, Xiaoxian Wu, Zhengchao Zhang, Zhihui Lu, Keke Wu, Jinshan Guo
Summary: Tannic acid-bridged CeO2 microcubes and chitosan cryogel were fabricated to create a multifunctional wound dressing. The cryogel displayed suitable porous structure and swelling rate and showed excellent tissue adhesion, blood cell coagulation, anti-infection, and cell recruitment functions. In vivo studies showed improved cell proliferation, tissue remodeling, angiogenesis, collagen deposition, and granulation tissue formation, indicating its potential clinical application value.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Immunology
Naqi Lian, Xing Mao, Yanchao Su, Yanyan Wang, Yaoqi Wang, Yuzun Wang, Hongguang Chen, Ruqing Zhu, Yonghao Yu, Keliang Xie
Summary: This study demonstrates that hydrogen can alleviate LPS-induced mitochondrial dynamic injury in HUVECs by up-regulating HO-1.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhongyuan Tang, Zonghui Zhang, Jiaqi Wang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang, Qiying Yao
Summary: Phosphocreatine (PCr) can suppress H2O2-induced apoptosis in endothelial cells and reduce hyperlipidemia by inhibiting ROS generation and modulating the dysfunctional mitochondrial system, which might be an effective new therapeutic strategy to prevent atherosclerosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Materials Science, Biomaterials
Yang Yang, Alastair Campbell Ritchie, Nicola M. Everitt
Summary: Soft hydrogel scaffolds based on recombinant human collagen and carboxylated chitosan showed promising potential in soft tissue engineering, with tunable properties by adjusting the RHC-to-chitosan ratio or total polymer concentration. The materials exhibited good biocompatibility and mechanical properties, making them suitable for biomedical applications.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Applied
Zijuan Yu, Dawei Yu, Junli Dong, Wenshui Xia
Summary: This study investigated the polyelectrolyte complexation between chitosan and chondroitin sulfate, as well as the ultrasonication assistance, for the encapsulation of proanthocyanidin in nanoparticles. The optimal conditions for the preparation of nanoparticles were determined to be 1.5 mg/mL of chitosan and chondroitin sulfate, a 1:3 wt ratio of chitosan/chondroitin sulfate, 0.5 mg/mL of proanthocyanidin, pH 3.25, and 1 min of ultrasonic treatment. The resulting nanoparticles had a small size of approximately 300 nm and high entrapment efficiency of 37.5%. The incorporation of proanthocyanidin-encapsulated nanoparticles into chitosan bio-films decreased the bacterial count and lipid oxidation of stored fillets, demonstrating their potential application in food preservation.
FOOD HYDROCOLLOIDS
(2022)
Article
Engineering, Chemical
Qiang Sun, Xuebin Hu, Qiang He, Manli Sun, Liangliang Dai, Sarfaraz Khan, Huaili Zheng
Summary: This study achieved the spatiotemporal coagulation and degradation of diclofenac sodium under visible light irradiation by modifying TiO2 nanoparticles. The modified TiO2 nanoparticles showed activated photocatalytic activity and improved photocatalytic efficiency. Additionally, it was found that the coagulant could be directly reused multiple times.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Biochemistry & Molecular Biology
Zixun Wang, Yang Yang, Yunbo Gao, Zhaoxian Xu, Shulin Yang, Mingjie Jin
Summary: This study successfully developed a UV-curable bioink system based on a novel water-soluble recombinant human collagen. The bioink demonstrated good biocompatibility and printability, and supported the expression of extracellular matrix and angiogenesis-associated proteins, enhancing cell viability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)