Article
Medicine, Research & Experimental
Trevor Teafatiller, Sreya Subramanian, Felerico E. Marquez, Masashi Kitazawa, Veedamali S. Subramanian
Summary: This study found that valproic acid (VPA) can upregulate the functional expression of human sodium-dependent vitamin C transporter-2 (hSVCT2) in neuronal cells. This upregulation is associated with increased hSVCT2 expression and SLC23A2 promoter activity, as well as upregulation of the transcription factor Yin Yang-1 (YY1).
Article
Biochemistry & Molecular Biology
Veedamali S. Subramanian, Trevor Teafatiller, Hamid Moradi, Jonathan S. Marchant
Summary: Intestinal absorption of vitamin C in humans is mediated by specific transporters, with decreased expression in patients with inflammatory bowel disease. In this study, histone deacetylase inhibitors were found to significantly decrease the expression and function of hSVCT1 in intestinal epithelial cells, partly mediated through transcription factor regulation and chromatin modification. Epigenetic regulation of SVCT1 expression in intestinal epithelia was demonstrated through HDAC isoforms two and three, with potential implications for vitamin C homeostasis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Trevor Teafatiller, Oasis Perez, Masashi Kitazawa, Anshu Agrawal, Veedamali S. Subramanian
Summary: The study reveals the important role of Nedd4-1 and the proteasomal degradation pathway in regulating the functional expression of hSVCT2 in neuronal cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Trevor Teafatiller, Sudhanshu Agrawal, Gabriela De Robles, Farah Rahmatpanah, Veedamali S. Subramanian, Anshu Agrawal
Summary: Vitamin C exerts its antiviral and protective functions in the lungs by upregulating metabolic pathways and interferon-stimulated genes, while simultaneously downregulating pathways related to lung injury and inflammation. Additionally, vitamin C enhances the expression of viral-sensing receptors, contributing to its antiviral effects.
Article
Chemistry, Multidisciplinary
Binbin Gu, Jeroen S. Dickschat
Summary: 2-Methylisoborneol is a common microbial odorant produced by various bacteria such as actinomycetes, cyanobacteria, and myxobacteria. Two phylogenetically distinct 2-methylisoborneol synthases (MIBS) were found to be highly active for its biosynthesis. Extensive study on the MIBS from Streptomyces coelicolor was conducted through site-directed mutagenesis, based on the enzyme structure and amino acid sequence alignment.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Neurosciences
Tyler W. E. Steele, Zachary Spires, Charles B. Jones, Richard A. Glennon, Malgorzata Dukat, Jose M. Eltit
Summary: Clandestine chemists are developing new designer drugs using the pyrrolidinophenone scaffold, which carry the risks of abuse and overdose. Mutagenesis studies have shown that non-conserved residues can influence the selectivity of MDPV.
Article
Agriculture, Dairy & Animal Science
Yufei Zhu, Wei Guo, Jianfei Zhao, Kailong Qin, Jiakun Yan, Xinhuo Huang, Zhouzheng Ren, Xin Yang, Yanli Liu, Xiaojun Yang
Summary: The study showed that dietary VC supplementation can enhance VC absorption in the duodenum and magnum, but reduce endogenous VC synthesis in the liver and kidney, with positive effects on VC transportation in the ovary and magnum. However, it does not increase VC deposition in produced eggs.
Article
Biochemistry & Molecular Biology
Judith Rose, Boje Mueller, Sira Groscurth, Jonas Giese, Juergen Eirich, Iris Finkemeier, Richard M. Twyman, Dirk Pruefer, Gundula A. Noll
Summary: This study investigates the unexpected disintegration of artificial forisomes in response to Ca2+ and proposes a model to explain this phenomenon. By deleting the M1 motif or replacing cysteine residues, this disintegration can be mimicked in wild-type forisomes. The findings support the rational engineering of disintegrating forisomes to control the release of peptides or enzymes in microfluidic systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Tiziana Ottone, Isabella Faraoni, Giorgio Fucci, Mariadomenica Divona, Serena Travaglini, Eleonora De Bellis, Francesco Marchesi, Daniela Francesca Angelini, Raffaele Palmieri, Carmelo Gurnari, Manuela Giansanti, Anna Maria Nardozza, Federica Montesano, Emiliano Fabiani, Elisa Linnea Lindfors Rossi, Raffaella Cerretti, Laura Cicconi, Marco De Bardi, Maria Luisa Catanoso, Luca Battistini, Renato Massoud, Adriano Venditti, Maria Teresa Voso
Summary: This study found that vitamin C levels are significantly lower in AML patients at the time of initial diagnosis, further decreasing during disease progression, and returning to normal upon achievement of complete remission. Additionally, vitamin C levels are significantly lower in AML cells compared to healthy cells. However, there is no association between vitamin C levels and the mutation profile, cytogenetics, or risk stratification of AML patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
H. B. Zhou, X. Y. Huang, Z. Bi, Y. H. Hu, F. Q. Wang, X. X. Wang, Y. Z. Wang, Z. Q. Lu
Summary: Vitamin A production requires antioxidants to prevent degradation, with Vitamin C sodium showing better antioxidant capacity in vitro. The study found that Vitamin C sodium Vitamin A significantly improved growth performance, antioxidant capacity, and immune function in weaned pigs.
Article
Chemistry, Multidisciplinary
Maria-Beatrice Coltelli, Pierfrancesco Morganti, Valter Castelvetro, Andrea Lazzeri, Serena Danti, Bouchra Benjelloun-Mlayah, Alessandro Gagliardini, Alessandra Fusco, Giovanna Donnarumma
Summary: In this study, chitin nanofibrils and nanolignin were used to create nanostructured complexes with antimicrobial, anti-inflammatory, and antioxidant properties. Active molecules and nano-silver were embedded to enhance functionality. The resulting complexes exhibited good thermal stability and compatibility with skin, making them suitable for various applications.
Article
Neurosciences
Anna M. Lipkin, Margaret M. Cunniff, Perry W. E. Spratt, Stefan M. Lemke, Kevin J. Bender
Summary: The study revealed that in mouse layer 5 prefrontal pyramidal neurons, calcium channels were distributed differently, with Ca(V)3 channels leading to high-spot calcium influx in specific regions, while Ca(V)2 channels localized to non-hotspot areas.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Chaweewan Sirakawin, Dongfa Lin, Ziyue Zhou, Xiaoxin Wang, Rhianne Kelleher, Shangyuan Huang, Weimiao Long, Andre Pires-daSilva, Yu Liu, Jingjing Wang, Ilya A. Vinnikov
Summary: This study found that vitamin A can extend lifespan, reduce fat accumulation and lipofuscin production, and increase resistance to heat and oxidative stress in Caenorhabditis elegans. This resistance is attributed to the high levels of detoxifying enzymes induced by vitamin A. Additionally, the study found that vitamin A can upregulate the expression of related genes in human cells and mouse liver tissues.
Article
Microbiology
Stewart Fannin, Jonathan Rangel, Abiodun P. Bodurin, Tannon Yu, Brandon Mistretta, Sujina Mali, Preethi Gunaratne, Steven J. Bark, Jerry O. Ebalunode, Arshad Khan, William R. Widger, Mehmet Sen
Summary: Membrane proteins, particularly in Mycobacterium tuberculosis, play crucial roles in drug targeting and pathogenic bacteria resistance. Research on the hypothetical membrane protein 730 (Hyp730) has provided insights into its upregulation during dormancy and its potential utilities in energy-saving roles under stress conditions. Further proteomic and transcriptomic analysis, as well as biophysical studies, have characterized the structure and function of Hyp730 in M. luteus.
Article
Chemistry, Applied
Xiaohan Li, Chengcheng Liu, Fengmao Liu, Xianzhao Zhang, Qingrong Peng, Ge Wu, Jin Lin, Zhanping Zhao
Summary: Ozone microbubbles treatment is a simple and effective method for removing pesticide residues, especially on cowpea. Among the pesticides tested, emamectin benzoate showed the highest removal rate due to its chemical structure. However, cowpea had a lower removal rate due to its stomata and rough surface.