Review
Engineering, Biomedical
Yiting Lou, Huiming Wang, Guanchen Ye, Yongzheng Li, Chao Liu, Mengfei Yu, Binbin Ying
Summary: This review discusses the important role of periosteum in bone defect repair and regeneration, as well as the need for developing tissue-engineered periosteum (TEP). The construction strategies for TEP are explored from the perspectives of materials, mechanical properties, cell-based strategies, and combination with growth factors. Current challenges and future perspectives for TEP development are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Jinsong Wang, Guobao Chen, Zhong M. Chen, Fu P. Wang, Bin Xia
Summary: The role of periosteum in the treatment of bone defects has been gradually discovered, but there are still challenges due to limited transplantable periosteum. Biomimetic periosteal scaffolds that mimic the composition and structure of natural periosteum have emerged. This article reviews the current preparation methods of biomimetic periosteal scaffolds based on various biomaterials, providing a systematic perspective for future preparation.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Cell Biology
Hai Xin, Sara Romanazzo, Eva Tomaskovic-Crook, Timothy C. Mitchell, Jui Chien Hung, Steven G. Wise, Kai Cheng, D. S. Abdullah Al Maruf, Murray J. Stokan, Timothy G. H. Manzie, Krishnan Parthasarathi, Veronica K. Y. Cheung, Ruta Gupta, Mark Ly, Carlo Pulitano, Innes K. Wise, Jeremy M. Crook, Jonathan R. Clark
Summary: We have developed an ex vivo perfusion bioreactor system to preserve surgically resected periosteal flaps, demonstrating long-term cell viability and metabolism. This proof-of-concept study paves the way for innovative bone engineering approaches using autotransplanted periosteum to enhance in vivo bone repair.
Article
Biophysics
Peng Liu, Tiecheng Qiu, Jiabing Liu, Xiaoxi Long, Xianwei Wang, Hemin Nie, Mengqiang Yu, Chao Ma, Nan Lin, Swee Hin Teoh, Zuyong Wang
Summary: Researchers have developed a biomimetic film with the potential to be used as a synthetic periosteum. This film, made of a blend of poly(epsilon-caprolactone) and microtantalum particles, shows enhanced surface wettability and mechanical strength. It also promotes cell proliferation, alignment, and osteogenic enhancement.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Emerito Carlos Rodriguez-Merchan
Summary: This article reviews recent findings on the molecular mechanisms of bone healing and presents various biological alternatives for treating recalcitrant nonunions, such as using morin, BMP9, and leptin. It also discusses factors that impact bone regeneration, including inhibition of estrogen receptor signaling, smoking-induced inflammatory responses, and delayed fracture healing in diabetic animals due to BMP6 deficiency. The combination of bioceramics and expanded autologous human mesenchymal stem cells from bone marrow is highlighted as a promising alternative for treating nonunions that do not respond well to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Anna Bertran Faus, Jose Cordero Bayo, Eugenio Velasco-Ortega, Aina Torrejon-Moya, Francesca Fernandez-Velilla, Fernando Garcia, Jose Lopez-Lopez
Summary: This paper presents a case report on the use of customized titanium mesh for posterior vertical bone regeneration, demonstrating that this technique is feasible and predictable.
Review
Orthopedics
Wentao Zhang, Naiguo Wang, Ming Yang, Tianze Sun, Jing Zhang, Yantao Zhao, Na Huo, Zhonghai Li
Summary: The periosteum plays a significant role in bone formation and regeneration by storing progenitor cells and acting as a source of growth factors. Tissue-engineered periosteum, produced using biomimetic methods, can significantly improve the efficacy of bone grafting and scaffold engineering. The development of bionic periosteum in tissue engineering aims to accelerate bone defect repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Chemistry, Multidisciplinary
Adham Hussein Abdullah Farea Al-akhali, Zhengqiang Tang
Summary: This study successfully fabricated metal-based superhydrophilic and underwater superoleophobic porous materials by hydrothermal treatment of stainless steel meshes combined with magnetron sputtering. The modified meshes showed unique broccoli-like microstructures coated with thin TiO2-xNx/WO3 films and exhibited superhydrophilicity and underwater superoleophobicity. They maintained strong hydrophilicity for more than three weeks and could recover their initial superhydrophilicity after post-annealing. The fabricated materials had a significant water flow rate and satisfactory oil-water separation efficiency for various oil-water mixtures.
Article
Biochemistry & Molecular Biology
Daisuke Kido, Keiji Komatsu, Toshikatsu Suzumura, Takanori Matsuura, James Cheng, Jeong Kim, Wonhee Park, Takahiro Ogawa, Luigi Canullo
Summary: The objective of this study was to identify determinants of surface wettability of titanium and establish the reliability and validity of the assessment. The study found that the age of titanium specimens and surface roughness significantly affected wettability, while UV treatment could recover superhydrophilicity. Surface conditioning techniques, such as autoclaving and alcohol cleaning, could also affect wettability. Therefore, age-standardization is necessary when evaluating surface wettability of titanium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Materials Science, Multidisciplinary
Ricard Aceves-Argemi, Elisabet Roca-Millan, Beatriz Gonzalez-Navarro, Antonio Mari-Roig, Eugenio Velasco-Ortega, Jose Lopez-Lopez
Summary: This systematic review analyzed the use of titanium meshes in bone regeneration, showing an average bone gain of 4.3 mm, high survival and success rates of implants, but a significant risk of mesh exposure.
Article
Materials Science, Biomaterials
Akihiro Furuhashi, Yunia Dwi Rakhmatia, Yasunori Ayukawa, Kiyoshi Koyano
Summary: The aim of this study was to investigate the use of titanium membranes incorporated in poly (lactic-co-glycolic acid) (PLGA) for guided bone regeneration. The study found that the titanium membranes significantly affected the mechanical and chemical properties, with higher release of fluvastatin in the PLGA-FS group. Micro-CT, morphometrical analysis, and histological observations showed that the TM-PLGA-FS group significantly enhanced bone formation.
REGENERATIVE BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Qifan Wang, Zhiyong Ma, Ying Wang, Linna Zhong, Wenjia Xie
Summary: The study embedded nano-zirconium dioxide (ZrO2) powder in PCL material through a melt-mixing process and constructed a regular grid scaffold by 3D printing. The composite scaffold showed improved hydrophilicity and water absorption, facilitating cell adhesion, proliferation, and growth, as well as nutrient exchange. Furthermore, the addition of ZrO2 significantly enhanced the mechanical properties of the scaffold, leading to better biological activity and osteogenic differentiation compared to pure PCL materials.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Dentistry, Oral Surgery & Medicine
Michael B. Berger, D. Joshua Cohen, Michael M. Levit, Jennifer L. Puetzer, Barbara D. Boyan, Zvi Schwartz
Summary: Dielectric barrier discharge plasma treatment can enhance osseointegration by increasing surface wettability of vacuum-sealed implants. The response to DBD treatment varies between male and female rabbits, with male implants showing significant improvement in osseointegration compared to females.
Article
Engineering, Biomedical
Laijun Liu, Yuna Shang, Chaojing Li, Yongjie Jiao, Yanchen Qiu, Chengyi Wang, Yuge Wu, Qiuyun Zhang, Fujun Wang, Zhimou Yang, Lu Wang
Summary: The developed hierarchical nanostructured electrospun membrane with periosteum-mimic microenvironment, incorporating a calcium-binding peptide, showed enhanced osteogenic differentiation of rat-bone marrow-derived mesenchymal stem cells (rBMSCs) and promoted the regeneration of vascularized bone tissue.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Oncology
Jeong-Kui Ku, Jae-Young Kim, Baek-Il Kim, Jong-Ki Huh
Summary: Wound dehiscence after vertical bone augmentation in implant dentistry is a common complication. The quantitative light-induced fluorescence (QLF) technology was successfully used to determine the need for exposed mesh removal in one patient, while the other patient achieved secondary healing without removal.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Editorial Material
Otorhinolaryngology
Toshinori Iwai, Satomi Sugiyama, Hiroaki Kitajima, Makoto Hirota, Kenji Mitsudo
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Editorial Material
Otorhinolaryngology
Toshinori Iwai, Satomi Sugiyama, Makoto Hirota, Kenji Mitsudo
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Article
Otorhinolaryngology
Toshinori Iwai, Satomi Sugiyama, Yuichiro Hyashi, Makoto Hirota, Kenji Mitsudo
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Article
Cell Biology
Yuki Shiroto, Ryo Saga, Hironori Yoshino, Yoichiro Hosokawa, Keitaro Isokawa, Eichi Tsuruga
Summary: UV-B exposure activates MMP-2, through p38 pathway, to degrade fibrillin-1- and fibrillin-2-positive oxytalan fibers in cultured HNPCECs. MMP-2 inhibitors effectively suppress the degradation of these fibers. UV-B induced degradation of oxytalan fibers is mediated by the activation of active form of MMP-2.
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yasufumi Kosugi, Makoto Hirota, Naohito Tamai, Hikaru Takasu, Toshinori Iwai, Kenji Mitsudo
Summary: This study conducted a finite element analysis to determine the most secure implant positioning on the marginally resected mandible to support a fixed complete denture. The use of a greater-length isolated implant, placed neither too close to nor too far from the resected margin, can be an effective alternative to symmetrically positioned implants.
JOURNAL OF ORAL IMPLANTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tomoyo Nozato, Tomomichi Ozawa, Mikio Ozawa, Kohei Osawa, Makoto Hirota, Kenji Mitsudo
Summary: This report discusses a case of EBV-positive mucocutaneous ulcer in a patient with rheumatoid arthritis and vitiligo. The ulcer on the tongue spontaneously resolved after treatment, with no recurrence observed.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2022)
Article
Otorhinolaryngology
Soichiro Ishikawa, Toshinori Iwai, Satomi Sugiyama, Makoto Hirota, Kenji Mitsudo
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Editorial Material
Otorhinolaryngology
Satomi Sugiyama, Toshinori Iwai, Hiroaki Kitajima, Makoto Hirota, Kenji Mitsudo
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Article
Cell Biology
Makoto Hirota, Norio Hori, Yoshihiko Sugita, Takayuki Ikeda, Wonhee Park, Juri Saruta, Takahiro Ogawa
Summary: This study introduces a novel approach for delivering osteoblasts in bone integration, regeneration, and engineering. The age of the titanium material and the amount of protein adsorption were found to be important factors affecting the loading efficiency of osteoblasts.
Article
Engineering, Biomedical
Tatsuto Kageyama, Hikaru Akieda, Yukie Sonoyama, Ken Sato, Hiroshi Yoshikawa, Hitoshi Isono, Makoto Hirota, Hiroaki Kitajima, Yang-Sook Chun, Shoji Maruo, Junji Fukuda
Summary: This study proposes a hydrogel microbead-based approach for preparing vascularized and high-density tissue grafts, demonstrating the significant effects of endothelialization on in vivo bone regeneration. The spontaneous constriction of mesenchymal stem cell-encapsulated collagen microgels improves the density and osteogenic differentiation of the cells, enhancing the efficacy of engraftment and bone regeneration.
ACTA BIOMATERIALIA
(2023)
Article
Cell Biology
Hiroaki Kitajima, Makoto Hirota, Keiji Komatsu, Hitoshi Isono, Takanori Matsuura, Kenji Mitsudo, Takahiro Ogawa
Summary: This study evaluated the capacity of a UV-photofunctionalized titanium microfiber scaffold for vertical bone augmentation. The results showed that the UV-treated scaffolds absorbed more fluids, had better cell attachment and growth, and exhibited stronger integration with host bone compared to untreated scaffolds. This indicates that the combination of titanium microfiber scaffolds and UV photofunctionalization is a promising strategy for vertical bone augmentation.
Article
Biochemistry & Molecular Biology
Hiroaki Kitajima, Makoto Hirota, Toshinori Iwai, Kenji Mitsudo, Juri Saruta, Takahiro Ogawa
Summary: This study demonstrates the influence of implant surface properties on protein and blood flow, and their impact on osseointegration. A microrough implant surface reduces protein infiltration and slows blood flow, while a superhydrophilic surface increases protein infiltration and slows down blood flow. Overall, superhydrophilicity has a consistently positive effect on protein recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Dentistry, Oral Surgery & Medicine
Toshinori Iwai, Satomi Sugiyama, Makoto Hirota, Kenji Mitsudo
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hiroaki Kitajima, Makoto Hirota, Kohei Osawa, Toshinori Iwai, Juri Saruta, Kenji Mitsudo, Takahiro Ogawa
Summary: This study examined the effects of implant threads and surface hydrophilicity on blood and protein dynamics. The results showed that the hydrophilicity of the implant surface had a profound impact on the distribution of blood and proteins, with superhydrophilic implants eliminating blood voids and promoting stable blood flow.
JOURNAL OF PROSTHODONTIC RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Koichi Fujita, Shuhei Minamiyama, Risa Usumi-Fujita, Susumu Omura, Hikaru Takasu, Yosuke Yamashita, Koji Honda, Haruki Imai, Toshinori Iwai, Makoto Hirota, Takashi Ono, Kenji Mitsudo
Summary: This study evaluated the effects of two types of MAC surgery on patients with skeletal Class II open bite. The results showed that neither MAC-1 group nor MAC-2 group exhibited significant changes in condylar surface area leading to skeletal relapse, with MAC surgery combined with SLM technique providing promising functional and morphological stability.
