Article
Biochemistry & Molecular Biology
Judith Caroline Ngo Nyobe, Willifred Dongmo Tekapi Tsopgni, Jean Pierre Longue Ekon, Ali Ben Saida, Annie Guilaine Djuidje, Anicet Biwole Bengondo, Gisele Etame Loe, Guillaume Berionni, Desire Bikele Mama, Jean Claude Ndom, Emmanuel Mpondo Mpondo
Summary: Chemical study of the stems extract of Psychotria arborea Hiern resulted in the isolation of thirteen compounds, including anthraquinones, diterpenes, triterpenes, flavonoid, sterols, and a fatty acid. These compounds showed no antibacterial activity and have certain chemotaxonomic significance.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Plant Sciences
Renata Trevizan, Joao Custodio Fernandes Cardoso, Christiano Peres Coelho, Helder Consolaro, Marco Tulio Furtado, Paulo Eugenio Oliveira
Summary: This study aimed to understand the different components of reciprocity in heterostylous flowers and how they relate to each other, as well as to explore the influence of factors such as genus, morph-ratio variation, and corolla tube length on imprecisions in sexual organs within populations. Results showed that maladaptive bias of low organs was higher than other inaccuracies, and there was no significant relation between genus, morph-ratio variation, or corolla tube length on general inaccuracy measurements. Pollinator-mediated selection on floral traits did not differ markedly among the studied distylous Rubiaceae species, highlighting the importance of using standardized reciprocity indices for cross-populational investigations.
PERSPECTIVES IN PLANT ECOLOGY EVOLUTION AND SYSTEMATICS
(2021)
Article
Genetics & Heredity
Xiaoshan Geng, Rong Chen, Bo Li, Yulin Zhu, Qin Liu
Summary: In this study, we obtained and characterized the complete chloroplast genome sequence of Psychotria asiatica. The phylogenetic analysis confirmed the close relationship between P. asiatica and Psychotria kirkii within the Rubiaceae family.
MITOCHONDRIAL DNA PART B-RESOURCES
(2022)
Article
Plant Sciences
D. Naidoo, J. C. Manning, L. P. Slavetinska, J. Van Staden
Summary: Isoquinoline alkaloids from the Amaryllidaceae family are valuable in drug discovery, with Distichamine 1 found in Crossyne guttata suggesting wider distribution than originally thought.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Plant Sciences
Rhaniel Nicholas Lisowski Goncalves, Jorge Ernesto de Araujo Mariath
Summary: This study investigated the floral morphoanatomy of Psychotria leiocarpa, Psychotria carthagenensis, and Psychotria brachyceras, revealing specific characteristics that are informative for phylogenetic studies within the genus and the alliance. The results showed distinct features in the flower structure and anatomy of these species, highlighting their relevance in understanding the taxonomy and evolution of Psychotria.
Article
Plant Sciences
Nicolas De Palma, Anna Carolina Alves Yendo, Johnatan Vilasboa, Daisy Sotero Chacon, Arthur Germano Fett-Neto
Summary: Under natural conditions, plants face complex scenarios of combined or sequential environmental stresses. Antioxidant systems play a crucial role in the biochemical regulation of plants, including the interaction between specialized metabolites and central pathways. The metabolic responses of Psychotria brachyceras Mull Arg., an alkaloid accumulating plant, were analyzed under individual, sequential, and combined stress conditions. Different stress application schemes had varying effects on alkaloid accumulation, proline, and carotenoids, constituting a complementary triad of antioxidants. This study provides insights that can aid in developing a framework for stress responses and their balance to enhance tolerance and yield of specialized metabolites.
JOURNAL OF PLANT RESEARCH
(2023)
Article
Agricultural Engineering
Xuejia Zhang, Li-E. Yang, Yanyun Hu, Xingdong Wu, Zhe Wang, Yuanyuan Miao, Hang Sun, Zelong Nie, Ninghua Tan
Summary: The study utilized a combination of morphology, molecular phylogeny, and chemotaxonomy to identify and discriminate Rubia species. DNA barcoding and multivariate statistical analysis revealed triterpenes and Rubiaceae-type cyclopeptides as the main chemotaxonomic markers. Furthermore, the origin and distribution center of the characteristic Rubiaceae-type cyclopeptides in Rubia species were inferred to be in Southwest China. The findings highlight the importance of a synthesis of morphology, molecular phylogeny, and chemotaxonomy in authentication and exploration of high-quality germplasm resources for Rubiaceae-type cyclopeptides.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Multidisciplinary Sciences
Alessandro M. Varani, Saura R. Silva, Simone Lopes, Jose Beethoven Figueiredo Barbosa, Danilo Oliveira, Maria Alice Correa, Ana Paula Moraes, Vitor F. O. Miranda, Francisco Prosdocimi
Summary: Psychotria viridis is a plant species commonly found in the Amazon region that produces psychoactive compounds. This study presents the first genomic resources for P. viridis, including the assembly and annotation of its organellar genomes. The results provide insights into the genome biology and evolutionary history of this species and can be used for conservation strategies.
Article
Agriculture, Multidisciplinary
Silvio Uhlig, Oscar Daniel Rangel-Huerta, Hege H. Divon, Elin Rolen, Kari Pauchon, Mark W. Sumarah, Trude Vralstad, Justin B. Renaud
Summary: This study aimed to detect as many peptide ergot alkaloids and indole diterpenoids in ergot sclerotia by using LC-HRMS/MS approach. Specific product ions in MS/MS data sets were used for data extraction, revealing different alkaloids specific for certain species within the Claviceps purpurea complex.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Abimbola O. Aro, Ibukun M. Famuyide, Ademola A. Oyagbemi, Prudence N. Kabongo-Kayoka, Lyndy J. McGaw
Summary: Tuberculosis (TB) and helminth infections are globally important diseases that affect approximately one-third of the global population. The acetone extract and fractions of Psychotria capensis show antimycobacterial and anthelmintic activities, with low cytotoxicity. However, the hexane fraction exhibits the best dual anthelmintic and antimycobacterial activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Andreas Berger, Karin Valant-Vetschera, Johann Schinnerl, Lothar Brecker
Summary: The diverse alkaloids found in the genus Palicourea have been examined and organized based on their structures and biosynthetic groups. Potential biosynthetic pathways have been proposed using a parsimony-based approach, highlighting important steps and relationships between these alkaloids. Understanding the diversification of alkaloids is crucial for studying the ecological significance and evolution of biosynthetic capabilities of Palicourea, and can drive future investigations on the biochemical and genetic background.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Plant Sciences
Quoc Bao Nguyen, Van Toan Em Quach, Huu Duc Huynh, Quoc Trong Pham, Ba Vuong Truong, Tetsukazu Yahara, Shuichiro Tagane, Van-Son Dang
Summary: This article describes and illustrates a new species, Psyhotria ngotphamii, discovered in Bidoup-Nui Ba National Park in Lam Dong Province, Vietnam. It provides photographs, vernacular name, preliminary conservation assessment, and a table comparing P. ngotphamii with its closest allies.
Article
Chemistry, Medicinal
Almir Ribeiro De Carvalho Junior, Rafaela Oliveira Ferreira, Michel de Souza Passos, Milena Goncalves Curcino Vieira, Lorena de Lima Gloria das Virgens, Sanderson Dias Calixto, Thatiana Lopes Bia Ventura, Elena Lassounskaia, Mario Geraldo de Carvalho, Raimundo Braz-Filho, Ivo Jose Curcino Vieira
Summary: This study identified and characterized major compounds with anti-tuberculosis and anti-inflammatory activities in the leaves of Psychotria suterella, highlighting the potential of triterpene 3-O-acethyloleanolic acid as a promising antimycobacterial agent.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Plant Sciences
Andreas Berger, Karin Valant-Vetschera, Johann Schinnerl, Lothar Brecker
Summary: Tribes Palicoureeae and Psychotrieae, belonging to the Rubiaceae family in the Gentianales order, are closely related and widely distributed around the world. A review of phytochemical literature was conducted, based on phylogenetic analysis and taxonomic updates, assigning previously reported phytochemical data for Psychotria to other genera such as Carapichea, Eumachia, and Palicourea. This study challenges the conventional understanding of Psychotria as a genus rich in monoterpene-indole alkaloids and highlights the specific alkaloid profile of each of its relatives. This research is of great importance for understanding animal-plant interactions and drug discovery.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Plant Sciences
Andreas Berger
Summary: Psychotria philippensis, described in 1829, is a Philippine endemic plant that has been controversial in terms of its taxonomic identity. Through a comprehensive analysis of morphology, type locality, and ecology, as well as a review of relevant literature, the identity of P. philippensis has finally been clarified as a synonym of Scyphiphora hydrophylacea. This confirmation is supported by the designation of a new neotype, reducing the number of Philippine Psychotria species. Despite this reduction, P. philippensis has not gone extinct.
Article
Biotechnology & Applied Microbiology
Crisfel R. del Mundo, Agnes L. Castillo, Seong Soo A. An, Mario A. Tan
Article
Biotechnology & Applied Microbiology
Mario A. Tan, Mark Wilson D. Lagamayo, Grecebio Jonathan D. Alejandro, Seong Soo A. An
Article
Biotechnology & Applied Microbiology
Mario A. Tan, Sarleen G. Castro, Patricia Marie P. Oliva, Paul Raymund J. Yap, Atsushi Nakayama, Hilbert D. Magpantay, Thomas Edison E. dela Cruz
Article
Biotechnology & Applied Microbiology
Mario A. Tan, Sebastian Jesus B. Gonzalez, Grecebio Jonathan D. Alejandro, Seong Soo A. An
Article
Biology
Mario A. Tan, Elena Zakharova, Seong Soo A. An
Summary: Alzheimer's disease is a progressive neurodegenerative illness affecting mainly elderly individuals, and the compounds Diaportheones A1 and A2 may have potential therapeutic effects against this disease.
Review
Biotechnology & Applied Microbiology
Rob T. Lumio, Mario A. Tan, Hilbert D. Magpantay
Summary: Plastic additives play a crucial role in determining the properties of plastic products. Their high demand poses environmental and health risks, making bioremediation a cost-efficient and sustainable method for their removal from the environment. Microbial activity is key in detoxifying these compounds and improving the efficiency of bioremediation processes.
Article
Biotechnology & Applied Microbiology
Mario A. Tan, Byron Leander U. Tan, Maribel G. Nonato, Seong Soo A. An
Summary: The study investigated the neuroprotective potential of Pandanus clementis extracts against amyloid-beta cytotoxicity in neuroblastoma cells, showing promising results in increasing cell viability, mitochondrial membrane potential, and decreasing reactive oxygen species levels.
Article
Pharmacology & Pharmacy
Seong Soo A. An, Kyu Hwan Shim, Shinwoo Kang, Young Kyo Kim, Lalita Subedi, Hyewon Cho, Seong-Min Hong, Mario A. Tan, Raok Jeon, Keun-A Chang, Sun Yeou Kim
Summary: This study demonstrated that SPA1413 has potent inhibitory effects on amyloid-beta fibrilization and oligomerization, as well as neuroprotective effects in cell and animal models of Alzheimer's disease. The results strongly suggest the potential of repurposing SPA1413 for the treatment of Alzheimer's disease due to its anti-amyloidogenic and anti-neuroinflammatory actions, supported by its fast-track status from the US FDA for cancer treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Niti Sharma, Mario A. Tan, Seong Soo A. An
Summary: Phytosterols, a class of natural products, are crucial components in diet and have various applications in foods, cosmetics, and herbal medicines. Stigmasterol and beta-sitosterol are common types of phytosterols with significant activities related to neurodegenerative diseases. This mini-review provides an overview of research on selected phytosterols associated with neurodegenerative diseases, covering major phytosterols and their biological activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Niti Sharma, Mario A. Tan, Seong Soo A. An
Summary: This review evaluated the neuroprotective mechanisms exhibited by extracts from spices in ameliorating Alzheimer's disease, highlighting their ability to protect neurons from the disease through various pathways.
Article
Chemistry, Medicinal
Mario A. Tan, Niti Sharma, Seong Soo A. An
Summary: Neurodegenerative diseases mainly affect neurons, causing a loss of normal motor and cognitive functions. Plant extracts have gained interest as potential alternative medicines due to their various active components that can exert multiple pharmacological effects. Murraya koenigii leaves contain bioactive components with diverse pharmacological activities, including antioxidant, anti-inflammatory, anticancer, hepatoprotective, immunomodulatory, and neuroprotective effects.
Article
Pharmacology & Pharmacy
Vy Anh Tran, Giau Van Vo, Mario A. Tan, Joon-Seo Park, Seong Soo A. An, Sang-Wha Lee
Summary: This study reports the synthesis and functionalization of fluorescent mesoporous silicon nanoparticles decorated with graphene oxide, which can achieve specific targeting and controlled release of anticancer agents, with selective accumulation in the mitochondria of cancer cells.
Review
Biochemistry & Molecular Biology
Mario A. Tan, Niti Sharma, Seong Soo A. An
Summary: Plant-derived carbazole alkaloids are important compounds that have potential neuroprotective effects in ameliorating neurodegenerative diseases.
Article
Nutrition & Dietetics
Mario A. Tan, Hayato Ishikawa, Seong Soo A. An
Summary: The study found that extracts from Pandanus amaryllifolius have potential anti-Alzheimer's disease effects by inhibiting A beta aggregation, reducing oxidative stress, and reversing mitochondrial damage.
Article
Biotechnology & Applied Microbiology
Mario A. Tan, Seong Soo A. An
Article
Biochemistry & Molecular Biology
Ruidang Yang, Bijian He, Shengqi Zhang, Ruifeng Mei, Jiaqi Liu, Tianpeng Yin, Le Cai
Summary: In this study, the phytochemical analysis of Asparagus lycopodineus was conducted for the first time, leading to the isolation of 14 compounds. Among them, five compounds have never been found in the Asparagus genus before. Additionally, the results highlight the close evolutionary relationship among A. lycopodineus, A. cochinchinensis, and A. filicinus.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2024)
