The Circadian Clock in Skin

Clock genes, hair growth and aging

(2016) Mikhail Geyfman et al.   Aging-US

BMAL1-dependent regulation of the mTOR signaling pathway delays aging

(2016) Rohini V. Khapre et al.   Aging-US

Circadian rhythms on skin function of hairless rats: light and thermic influences

(2014) Ana Flo et al.   EXPERIMENTAL DERMATOLOGY

24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by Molecular Clocks

(2014) Naoya Matsunaga et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

(2014) Julie Gibbs et al.   NATURE MEDICINE

Emerging interactions between skin stem cells and their niches

(2014) Ya-Chieh Hsu et al.   NATURE MEDICINE

Cyclic Colour Change in the Bearded Dragon Pogona vitticeps under Different Photoperiods

(2014) Marie Fan et al.   PLoS One

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM

(2014) Thomas S. Blacker et al.   Nature Communications

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

(2014) B. A. Morgan   Cold Spring Harbor Perspectives in Medicine

Ras-Mediated Deregulation of the Circadian Clock in Cancer

(2014) Angela Relógio et al.   PLoS Genetics

The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth

(2013) Yuichi Watabe et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Cycling progenitors maintain epithelia while diverse cell types contribute to repair

(2013) David P. Doupé et al.   BIOESSAYS

Impaired leukocyte trafficking and skin inflammatory responses in hamsters lacking a functional circadian system

(2013) Brian J. Prendergast et al.   BRAIN BEHAVIOR AND IMMUNITY

Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

(2013) Atish Mukherji et al.   CELL

Microbiota Keep the Intestinal Clock Ticking

(2013) Jorge Henao-Mejia et al.   CELL

Human Epidermal Stem Cell Function Is Regulated by Circadian Oscillations

(2013) Peggy Janich et al.   Cell Stem Cell

Circadian Disruption Leads to Insulin Resistance and Obesity

(2013) Shu-qun Shi et al.   CURRENT BIOLOGY

The circadian clock and cell cycle: interconnected biological circuits

(2013) Selma Masri et al.   CURRENT OPINION IN CELL BIOLOGY

Circadian Regulation of Lipid Mobilization in White Adipose Tissues

(2013) A. Shostak et al.   DIABETES

Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue

(2013) Carolina Maria Berra et al.   FREE RADICAL BIOLOGY AND MEDICINE

Circadian clocks and tumor biology: What is to learn from human skin biopsies?

(2013) Zsuzsanna Lengyel et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Circadian regulation of allergic reactions by the mast cell clock in mice

(2013) Yuki Nakamura et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach

(2013) Raul Ramos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

(2013) Yusur Al-Nuaimi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Psoriasis and metabolic syndrome: A systematic review and meta-analysis of observational studies

(2013) April W. Armstrong et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Spatial organization within a niche as a determinant of stem-cell fate

(2013) Panteleimon Rompolas et al.   NATURE

Stem cell quiescence acts as a tumour suppressor in squamous tumours

(2013) A. C. White et al.   NATURE CELL BIOLOGY

A NONO-gate times the cell cycle

(2013) B. Maier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

(2013) Maksim V. Plikus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clock regulates the host response to Salmonella

(2013) M. M. Bellet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement modulates the cutaneous microbiome and inflammatory milieu

(2013) C. Chehoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell dynamics in the hair follicle niche

(2013) Panteleimon Rompolas et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Functions of the skin microbiota in health and disease

(2013) James A. Sanford et al.   SEMINARS IN IMMUNOLOGY

Genome-wide mapping of gene–microbiota interactions in susceptibility to autoimmune skin blistering

(2013) Girish Srinivas et al.   Nature Communications

Epidermal stem cells ride the circadian wave

(2013) Vivek Kumar et al.   GENOME BIOLOGY

Effect of Weight Loss on the Severity of Psoriasis

(2013) Peter Jensen et al.   JAMA Dermatology

Circadian regulation of adipose function

(2013) Anton Shostak et al.   Adipocyte

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Rhythmic expression of circadian clock genes in human leukocytes and beard hair follicle cells

(2012) Makiko Watanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biological clock dysfunction exacerbates contact hypersensitivity in mice

(2012) E. Takita et al.   BRITISH JOURNAL OF DERMATOLOGY

Circadian Disruption, Sleep Loss, and Prostate Cancer Risk: A Systematic Review of Epidemiologic Studies

(2012) L. G. Sigurdardottir et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

(2012) Ramiro Iglesias-Bartolome et al.   Cell Stem Cell

Human skin keratinocytes, melanocytes, and fibroblasts contain distinct circadian clock machineries

(2012) Cristina Sandu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chronobiology and the treatment of rheumatoid arthritis

(2012) Maurizio Cutolo   CURRENT OPINION IN RHEUMATOLOGY

Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter

(2012) T. Abe et al.   DEVELOPMENT

Sox2 in the Dermal Papilla Niche Controls Hair Growth by Fine-Tuning BMP Signaling in Differentiating Hair Shaft Progenitors

(2012) Carlos Clavel et al.   DEVELOPMENTAL CELL

The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway

(2012) Bingyan Guo et al.   FASEB JOURNAL

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

(2012) H. H. Kong et al.   GENOME RESEARCH

The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity

(2012) Adam C. Silver et al.   IMMUNITY

New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence

(2012) Maksim V. Plikus   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rotating Night-Shift Work and Risk of Psoriasis in US Women

(2012) Wen-Qing Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

Obesity in mice with adipocyte-specific deletion of clock component Arntl

(2012) Georgios K Paschos et al.   NATURE MEDICINE

Circadian Timing of Injury-Induced Cell Proliferation in Zebrafish

(2012) Maria Laura Idda et al.   PLoS One

Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis

(2012) Camila Hirotsu et al.   PLoS One

Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes

(2012) F. Sporl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solar UV radiation reduces the barrier function of human skin

(2012) K. Biniek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

(2012) M. Geyfman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NONO couples the circadian clock to the cell cycle

(2012) E. Kowalska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption

(2012) O. M. Buxton et al.   Science Translational Medicine

Epithelial stem cells and implications for wound repair

(2012) Maksim V. Plikus et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genetic pathways in disorders of epidermal differentiation

(2012) Vanessa Lopez-Pajares et al.   TRENDS IN GENETICS

Immunity's fourth dimension: approaching the circadian–immune connection

(2012) Alvaro Arjona et al.   TRENDS IN IMMUNOLOGY

Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors

(2012) Zsuzsanna Lengyel et al.   TUMOR BIOLOGY

Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

(2011) Eric Festa et al.   CELL

The Multitasking Organ: Recent Insights into Skin Immune Function

(2011) Paola Di Meglio et al.   IMMUNITY

Circadian clock gene Period2 regulates a time-of-day–dependent variation in cutaneous anaphylactic reaction

(2011) Yuki Nakamura et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Mechanisms of UV Mutagenesis

(2011) Hironobu IKEHATA et al.   JOURNAL OF RADIATION RESEARCH

The circadian molecular clock creates epidermal stem cell heterogeneity

(2011) Peggy Janich et al.   NATURE

Identifying the cellular origin of squamous skin tumors

(2011) G. Lapouge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of skin cancer by the circadian rhythm

(2011) S. Gaddameedhi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of metabolism: the circadian clock dictates the time

(2011) Saurabh Sahar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock

(2010) Rohini V. Khapre et al.   ANNALS OF MEDICINE

Light, Time, and the Physiology of Biotic Response to Rapid Climate Change in Animals

(2010) William E. Bradshaw et al.   Annual Review of Physiology

Circadian clocks and cell division

(2010) Carl Hirschie Johnson   CELL CYCLE

A Molecular Switch for Photoperiod Responsiveness in Mammals

(2010) Hugues Dardente et al.   CURRENT BIOLOGY

A Circadian Clock Is Not Required in an Arctic Mammal

(2010) Weiqun Lu et al.   CURRENT BIOLOGY

β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

(2010) David Enshell-Seijffers et al.   DEVELOPMENTAL CELL

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

 -Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching

(2010) D. Enshell-Seijffers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noninvasive method for assessing the human circadian clock using hair follicle cells

(2010) M. Akashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human skin pigmentation as an adaptation to UV radiation

(2010) N. G. Jablonski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

(2010) H. J. Snippert et al.   SCIENCE

Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation

(2009) Ken Inomata et al.   CELL

A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration

(2009) Valentina Greco et al.   Cell Stem Cell

Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

(2009) Kim B. Jensen et al.   Cell Stem Cell

The Hair Follicle as a Dynamic Miniorgan

(2009) Marlon R. Schneider et al.   CURRENT BIOLOGY

Differential maturation of circadian rhythms in clock gene proteins in the suprachiasmatic nucleus and the pars tuberalis during mouse ontogeny

(2009) Nariman Ansari et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

How the Skin Can Tell Time

(2009) Mikhail Geyfman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Implications of Multiple Circadian Clock Origins

(2009) Michael Rosbash   PLOS BIOLOGY

Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling

(2009) Kevin K. Lin et al.   PLoS Genetics

Roles of Aquaporin-3 in the Epidermis

(2008) Mariko Hara-Chikuma et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Molecular Clocks in Mouse Skin

(2008) Miki Tanioka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic Dermatitis: A Disease Caused by Innate Immune Defects?

(2008) Anna De Benedetto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

(2008) Maksim V. Plikus et al.   NATURE

Analysis of Gene Regulatory Networks in the Mammalian Circadian Rhythm

(2008) Jun Yan et al.   PLoS Computational Biology

Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents

(2007) Maksim V. Plikus et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY