From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?

Association between caffeine intake and age at onset in Huntington's disease

(2013) Clémence Simonin et al.   NEUROBIOLOGY OF DISEASE

Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice

(2013) C. G. Silva et al.   Science Translational Medicine

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model

(2012) Sylvie Burnouf et al.   AGING CELL

From A1 to A3 en passant Through A2A Receptors in the Hippocampus: Pharmacological Implications

(2012) Ana M. Sebastiao et al.   CNS & Neurological Disorders-Drug Targets

Detrimental Effects of Diet-Induced Obesity on   Pathology Are Independent of Insulin Resistance in   Transgenic Mice

(2012) A. Leboucher et al.   DIABETES

Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid- 1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model

(2012) J. Brouillette et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

(2012) V L Batalha et al.   MOLECULAR PSYCHIATRY

Caffeine for treatment of Parkinson disease: A randomized controlled trial

(2012) R. B. Postuma et al.   NEUROLOGY

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s Disease

(2012) Valérie Vingtdeux et al.   Frontiers in Physiology

Adenosine and Related Drugs in Brain Diseases: Present and Future in Clinical Trials

(2011) Luisa V. Lopes et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

(2011) Karim Belarbi et al.   NEUROBIOLOGY OF DISEASE

Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF

(2011) Maria J Diógenes et al.   NEUROPSYCHOPHARMACOLOGY

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Healthy Brain Aging: Role of Cognitive Reserve, Cognitive Stimulation, and Cognitive Exercises

(2010) Asenath La Rue   CLINICS IN GERIATRIC MEDICINE

Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet

(2010) Jaya R.P. Prasanthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic Mechanisms of Coffee Extract Protection in a Caenorhabditis elegans Model of  -Amyloid Peptide Toxicity

(2010) V. Dostal et al.   GENETICS

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caffeine Modulates Tau Phosphorylation and Affects Akt Signaling in Postmitotic Neurons

(2010) Antonio Currais et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Local Glutamate Level Dictates Adenosine A2A Receptor Regulation of Neuroinflammation and Traumatic Brain Injury

(2010) S. S. Dai et al.   JOURNAL OF NEUROSCIENCE

Decaffeinated Coffee and Nicotine-Free Tobacco Provide Neuroprotection in Drosophila Models of Parkinson's Disease through an NRF2-Dependent Mechanism

(2010) K. Trinh et al.   JOURNAL OF NEUROSCIENCE

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission

(2010) Ann Van der Jeugd et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Novel investigational adenosine A2Areceptor antagonists for Parkinson's disease

(2009) Annalisa Pinna   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by  -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

(2009) P. M. Canas et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

(2009) M. Polydoro et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2A receptor mediates microglial process retraction

(2009) Anna G Orr et al.   NATURE NEUROSCIENCE

Adenosine A2a receptor induced gliosis via Akt/NF-κB pathway in vitro

(2009) Rong-Hu Ke et al.   NEUROSCIENCE RESEARCH

Adenosine A2Areceptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms

(2008) Liqun Yu et al.   ANNALS OF NEUROLOGY

Adenosine A2A Receptor Antagonists and Parkinsons Disease: State of the Art and Future Directions

(2008) N. Simola et al.   CURRENT PHARMACEUTICAL DESIGN

Biochemistry of Tau in Alzheimer’s disease and related neurological disorders

(2008) Nicolas Sergeant et al.   Expert Review of Proteomics

Metabolic syndrome and the role of dietary lifestyles in Alzheimer’s disease

(2008) Giulio Maria Pasinetti et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine A2A receptor blockade prevents memory dysfunction caused by β-amyloid peptides but not by scopolamine or MK-801

(2007) Geanne M.A. Cunha et al.   EXPERIMENTAL NEUROLOGY

Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies

(2007) Reinaldo Naoto Takahashi   Frontiers in Bioscience-Landmark