Ribonuclease H2 in health and disease

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9

(2014) R. E. Rigby et al.   EMBO JOURNAL

Synonymous Mutations inRNASEH2ACreate Cryptic Splice Sites Impairing RNase H2 Enzyme Function in Aicardi-Goutières Syndrome

(2013) Gillian I. Rice et al.   HUMAN MUTATION

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study

(2013) Gillian I Rice et al.   LANCET NEUROLOGY

Topoisomerase 1-Mediated Removal of Ribonucleotides from Nascent Leading-Strand DNA

(2013) Jessica S. Williams et al.   MOLECULAR CELL

RNase H2 roles in genome integrity revealed by unlinking its activities

(2013) Hyongi Chon et al.   NUCLEIC ACIDS RESEARCH

Removal of Misincorporated Ribonucleotides from Prokaryotic Genomes: An Unexpected Role for Nucleotide Excision Repair

(2013) Alexandra Vaisman et al.   PLoS Genetics

A novelRNASEH2Bsplice site mutation responsible for Aicardi-Goutieres syndrome in the Faroe Islands

(2012) Elsebet Ostergaard et al.   ACTA PAEDIATRICA

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants

(2012) P. C. Stirling et al.   GENES & DEVELOPMENT

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

(2012) Bjoern Hiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNase H2-Initiated Ribonucleotide Excision Repair

(2012) Justin L. Sparks et al.   MOLECULAR CELL

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

(2012) Federico Lazzaro et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases

(2011) Danielle L. Watt et al.   DNA REPAIR

Analysis of subunit assembly and function of the Saccharomyces cerevisiae RNase H2 complex

(2011) Tuan Anh Nguyen et al.   FEBS Journal

Functional Consequences of the RNase H2A Subunit Mutations That Cause Aicardi-Goutières Syndrome

(2011) Stephanie R. Coffin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

(2011) Doryen Bubeck et al.   NUCLEIC ACIDS RESEARCH

An autoimmune disease prevented by anti-retroviral drugs

(2011) Gabriele B Beck-Engeser et al.   Retrovirology

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

The Major Roles of DNA Polymerases Epsilon and Delta at the Eukaryotic Replication Fork Are Evolutionarily Conserved

(2011) Izumi Miyabe et al.   PLoS Genetics

Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome

(2010) Georgia Ramantani et al.   ARTHRITIS AND RHEUMATISM

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

(2010) A. El Hage et al.   GENES & DEVELOPMENT

The Structural and Biochemical Characterization of Human RNase H2 Complex Reveals the Molecular Basis for Substrate Recognition and Aicardi-Goutières Syndrome Defects

(2010) Małgorzata Figiel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

(2010) Martin A. M. Reijns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aicardi-Goutières syndrome: an important Mendelian mimic of congenital infection

(2009) Yanick J Crow et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

The Structure of the Mammalian RNase H2 Complex Provides Insight into RNA·DNA Hybrid Processing to Prevent Immune Dysfunction

(2009) Nadine M. Shaban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Nucleic acid-mediated inflammatory diseases

(2008) Rachel E. Rigby et al.   BIOESSAYS

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII

(2008) Muhammad S. Rohman et al.   FEBS Journal

Polymerase Dynamics at the Eukaryotic DNA Replication Fork

(2008) Peter M. J. Burgers   JOURNAL OF BIOLOGICAL CHEMISTRY

RNaseH2 mutants that cause Aicardi–Goutieres syndrome are active nucleases

(2008) Fred W. Perrino et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex

(2008) Hyongi Chon et al.   NUCLEIC ACIDS RESEARCH