Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development

The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators

(2013) Markus Follmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Model of a Soluble Guanylyl Cyclase Fragment Determined by Small-Angle X-ray Scattering and Chemical Cross-Linking

(2013) Bradley G. Fritz et al.   BIOCHEMISTRY

Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes

(2013) Vijay Kumar et al.   BIOCHEMISTRY

Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Riociguat for the Treatment of Pulmonary Arterial Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase

(2013) Charles K. Allerston et al.   PLoS One

Structure and Regulation of Soluble Guanylate Cyclase

(2012) Emily R. Derbyshire et al.   Annual Review of Biochemistry

Mechanism of Binding of NO to Soluble Guanylyl Cyclase: Implication for the Second NO Binding to the Heme Proximal Site

(2012) Emil Martin et al.   BIOCHEMISTRY

Why do drugs for acute heart failure fail?

(2012) Adriaan A. Voors et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes

(2012) Mihai Gheorghiade et al.   EUROPEAN JOURNAL OF HEART FAILURE

Guanylyl Cyclases A and B Are Asymmetric Dimers That Are Allosterically Activated by ATP Binding to the Catalytic Domain

(2012) J. W. Robinson et al.   Science Signaling

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

(2012) Jonathan A Winger et al.   BMC STRUCTURAL BIOLOGY

Allosteric Modification, the Primary ATP Activation Mechanism of Atrial Natriuretic Factor Receptor Guanylate Cyclase

(2011) Teresa Duda et al.   BIOCHEMISTRY

Nucleotidyl Cyclase Activity of Soluble Guanylyl Cyclase α1β1

(2011) Kerstin Y. Beste et al.   BIOCHEMISTRY

Soluble Guanylate Cyclase as an Emerging Therapeutic Target in Cardiopulmonary Disease

(2011) Johannes-Peter Stasch et al.   CIRCULATION

Identification of Residues in the Heme Domain of Soluble Guanylyl Cyclase that are Important for Basal and Stimulated Catalytic Activity

(2011) Padmamalini Baskaran et al.   PLoS One

Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain

(2011) M. B. Winter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP allosteric activation of atrial natriuretic factor receptor guanylate cyclase

(2010) Teresa Duda et al.   FEBS Journal

Structure of Cinaciguat (BAY 58–2667) Bound toNostocH-NOX Domain Reveals Insights into Heme-mimetic Activation of the Soluble Guanylyl Cyclase

(2010) Faye Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclase

(2010) Xiaolei Ma et al.   BMC STRUCTURAL BIOLOGY

Nucleotide Regulation of Soluble Guanylate Cyclase Substrate Specificity

(2009) Emily R. Derbyshire et al.   BIOCHEMISTRY

Role of soluble guanylyl cyclase–cyclic GMP signaling in tumor cell proliferation

(2009) Kalpana Mujoo et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase

(2009) N. B. Fernhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the guanylyl cyclase Cya2

(2008) A. Rauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA