Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 41, Issue -, Pages 1305-1311Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20130073
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Funding
- Creative Scientific Research Grant [18GS0314]
- Japanese Society for the Promotion of Science [18073004]
- Japanese Ministry of Education, Science, Culture, Sports and Technology (MEXT)
- BBSRC (Biotechnology and Biological Sciences Research Council)
- BBSRC [BB/E015328/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E015328/1] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [23370050, 23570131] Funding Source: KAKEN
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The alternative oxidases are membrane-bound monotopic terminal electron transport proteins found in all plants and in some agrochemically important fungi and parasites including Trypansoma brucei, which is the causative agent of trypanosomiasis. They are integral membrane proteins and reduce oxygen to water in a four electron process. The recent elucidation of the crystal structure of the trypanosomal alternative oxidase at 2.85 angstrom (1 angstrom = 0.1 nm) has revealed salient structural features necessary for its function. In the present review we compare the primary and secondary ligation spheres of the alternative oxidases with other di- iron carboxylate proteins and propose a mechanism for the reduction of oxygen to water.
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