Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue -, Pages 880-885Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20120065
Keywords
cell cycle; DNA replication; histone gene expression; RNA degradation; RNA processing; translation
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Funding
- University of Aberdeen
- Biotechnology and Biological Sciences Research Council studentship
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Histone proteins are essential for the packaging of DNA into chromosomes. Histone gene expression is cell-cycle-regulated and coupled to DNA replication. Control of histone gene expression occurs at the transcriptional and post-transcriptional level and ensures that a fine balance between histone abundance and DNA replication is maintained for the correct packaging of newly replicated DNA into chromosomes. In the present paper, we review histone gene expression, highlighting the control mechanisms and key molecules involved in this process.
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