‘Bac’ to the future: bioengineering lantibiotics for designer purposes

Discovery, Biosynthesis, and Engineering of Lantipeptides

(2012) Patrick J. Knerr et al.   Annual Review of Biochemistry

Increasing the success rate of lantibiotic drug discovery by Synthetic Biology

(2012) Manuel Montalbán-López et al.   Expert Opinion on Drug Discovery

Bioengineered Nisin A Derivatives with Enhanced Activity against Both Gram Positive and Gram Negative Pathogens

(2012) Des Field et al.   PLoS One

Bioengineered nisin derivatives with enhanced activity in complex matrices

(2012) Susan Rouse et al.   Microbial Biotechnology

Are Bacteriocins Underexploited? NOVEL Applications for OLD Antimicrobials

(2011) Manuel Montalban-Lopez et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans

(2011) Auke Johan van Heel et al.   Expert Opinion on Drug Metabolism & Toxicology

Production of a Class II Two-Component Lantibiotic of Streptococcus pneumoniae Using the Class I Nisin Synthetic Machinery and Leader Sequence

(2010) J. A. Majchrzykiewicz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides

(2010) Gert N. Moll et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

The dawning of a ‘Golden era’ in lantibiotic bioengineering

(2010) Des Field et al.   MOLECULAR MICROBIOLOGY

Studies with bioengineered Nisin peptides highlight the broad-spectrum potency of Nisin V

(2010) Des Field et al.   Microbial Biotechnology

To protect peptide pharmaceuticals against peptidases

(2010) R. Rink et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Bioengineering of a Nisin A-producing Lactococcus lactis to create isogenic strains producing the natural variants Nisin F, Q and Z

(2010) Clare Piper et al.   Microbial Biotechnology

Lantibiotics: Mode of Action, Biosynthesis and Bioengineering

(2009) G. Bierbaum et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A comparison of the activities of lacticin 3147 and nisin against drug-resistant Staphylococcus aureus and Enterococcus species

(2009) C. Piper et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

The Bacteriocin Nisin, an Effective Agent for the Treatment of Staphylococcal Mastitis During Lactation

(2008) Leonides Fernández et al.   JOURNAL OF HUMAN LACTATION

Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog

(2008) L. D. Kluskens et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The generation of nisin variants with enhanced activity against specific Gram-positive pathogens

(2008) Des Field et al.   MOLECULAR MICROBIOLOGY