Journal
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
Volume 20, Issue 2, Pages 403-433Publisher
SPRINGER
DOI: 10.1007/s00775-014-1234-2
Keywords
Molybdenum; Nitrite reduction; Nitric oxide; Cell signalling; Moonlighting
Funding
- Fundacao para a Ciencia e Tecnologia/MCTES, Portugal [PTDC/QUI-BIQ/100366/2008, PEst-C/EQB/LA0006/2013]
- Fundação para a Ciência e a Tecnologia [PTDC/QUI-BIQ/100366/2008] Funding Source: FCT
Ask authors/readers for more resources
Nitric oxide (NO) is a signalling molecule involved in several physiological processes, in both prokaryotes and eukaryotes, and nitrite is being recognised as an NO source particularly relevant to cell signalling and survival under challenging conditions. The non-respiratory nitrite reduction to NO is carried out by non-dedicated nitrite reductases, making use of metalloproteins present in cells to carry out other functions, such as several molybdoenzymes (a new class of nitric oxide-forming nitrite reductases). This minireview will highlight the physiological relevance of molybdenum-dependent nitrite-derived NO formation in mammalian, plant and bacterial signalling (and other) pathways. The mammalian xanthine oxidase/xanthine dehydrogenase, aldehyde oxidase, mitochondrial amidoxime-reducing component, plant nitrate reductase and bacterial aldehyde oxidoreductase and nitrate reductases will be considered. The nitrite reductase activity of each molybdoenzyme will be described and the review will be oriented to discuss the feasibility of the reactions from a (bio)chemical point of view. In addition, the molecular mechanism proposed for the molybdenum-dependent nitrite reduction will be discussed in detail.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available