Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 39, Issue -, Pages 961-965Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0390961
Keywords
bactericidal/permeability-increasing protein (BPI); BPI fold-containing (BPIF); lipopolysaccharide-binding protein (LBP); palate, lung and nasal epithelium clone (PLUNC)
Categories
Funding
- Wellcome Trust [107726]
- British Lung Foundation
- Sheffield Hospitals Charitable Trust
Ask authors/readers for more resources
PLUNC (palate, lung and nasal epithelium clone) proteins make up the largest branch of the BPI (bactericidal/permeability-increasing protein)/LBP (lipopolysaccharide-binding protein) family of lipid-transfer proteins. PLUNCs make up one of the most rapidly evolving mammalian protein families and exhibit low levels of sequence similarity coupled with multiple examples of species-specific gene acquisition and gene loss. Vertebrate genomes contain multiple examples of genes that do not meet our original definition of what is required to be a member of the PLUNC family, namely conservation of exon numbers/sizes, overall protein size, genomic location and the presence of a conserved disulfide bond. This suggests that evolutionary forces have continued to act on the structure of this conserved domain in what are likely to be functionally important ways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available