Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 39, Issue -, Pages 902-909Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0390902
Keywords
Alzheimer's disease (AD); amyloid beta-peptide (A beta); dentate gyrus (DG); episodic-like memory; hippocampal synaptic activity; pattern separation
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Funding
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
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The present review summarizes converging evidence from animal and human studies that an early target of amyloid pathology is synaptic activity in the DG (dentate gyrus)/CA3 network. We briefly review the computational significance of the DG/CA3 network in the encoding of episodic memory and present new evidence that the CA3/DG pattern of activation is compromised in a mouse model of amyloid pathology. In addition, we present a new behavioural method to test the prediction that amyloid-related synaptic pathology will disrupt the formation of an integrated episodic-like (what, where and when) memory in mice.
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