Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 38, Issue -, Pages 457-459Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0380457
Keywords
brain; exocytosis; glutamate; potassium channel; synaptosome
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Funding
- NIA NIH HHS [PL1 AG032118, P01 AG025901] Funding Source: Medline
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Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developments have greatly increased the sensitivity with which the bioenergetics of the intra-synaptosomal mitochondria can be investigated.
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