Article
Multidisciplinary Sciences
Te-Yao Hsu, Hsin-Hsin Cheng, Kuo-Chung Lan, Hsuan-Ning Hung, Yun-Ju Lai, Chih-Chang Tsai, Wen-Lang Fan, Sung-Chou Li
Summary: Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality, and early prediction of PTB is crucial for providing timely medical intervention. This study identified four protein biomarkers in amniotic fluid that were negatively correlated with neonatal weight and gestational age, and developed a prediction model with high accuracy for PTB.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Wei Yang, Xiaoqing Qu, Chujun Deng, Lei Dai, Haoyu Zhou, Guihua Xu, Bo Li, Nazarenko Yulia, Changzhong Liu
Summary: This study investigated the synergistic enhancement in the thermal co-aggregation and gelation of lactoferrin and alpha-lactalbumin under specific conditions. It found that there is a strong rheological synergism between the two proteins, leading to reduced gelation times. The research enhances understanding of heat sensitive protein-heat stable protein thermal aggregation and gelation processes.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Paziewska-Nowak, Marcin Urbanowicz, Kamila Sadowska, Dorota Genowefa Pijanowska
Summary: The paper describes the development and utility of a novel DNA oligonucleotide-based affinity bioreceptor for lactoferrin. The research investigates the affinity of different types of oligonucleotides to the target protein using surface plasmon resonance method. The selected DNA sequence showed high affinity to lactoferrin and demonstrated its potential as a bioreceptor for lactoferrin determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Line A. E. Hallberg, Nicoline W. Thorsen, Els A. Hartsema, Per M. Hagglund, Clare L. Hawkins
Summary: Histones play a critical role in packaging nuclear DNA and chromatin assembly. They can undergo a range of post-translational modifications, which affect their regulatory function. Histones can also be released into the extracellular environment through pathways such as neutrophil extracellular traps. This study investigates the reactivity of histones with hypochlorous acid and the potential implications for chronic inflammatory diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Fisheries
Wang-Jing Liu, Yun-Shiang Chang, Kou-Chun Tseng, Meng-Hua Yu
Summary: White spot syndrome virus (WSSV) is a prominent pathogen in shrimp farming worldwide. However, there is currently no effective treatment for this virus. In this study, the antiviral properties of bovine lactoferrin (bLF) against WSSV were investigated, and it was found that bLF treatment significantly reduced shrimp mortalities caused by WSSV infection. The ability of bLF to bind to both host cells and WSSV virions suggests its potential as an anti-WSSV agent in shrimp culture, and the identified interaction proteins may play a role in WSSV infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Clare L. Hawkins, Michael J. Davies
Summary: The heme peroxidase family, especially MPO, generates powerful oxidants for pathogen removal but also causes tissue damage and inflammatory diseases. MPO binds to extracellular biomolecules, leading to localized damage on specific sites and species, affecting cellular dysfunction and altered gene expression. MPO's interaction with damaged ECM components may explain its accumulation at sites of inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Michael J. Davies
Summary: Herne peroxidases are a major source of reactive oxidants involved in immune response, tissue development, and hormone synthesis. Improper production of these oxidants can lead to tissue damage and is associated with various inflammatory pathologies.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Aaron A. Thompson, Michael B. Harbut, Pei-Pei Kung, Nathan K. Karpowich, Jeffrey D. Branson, Joanna C. Grant, Deborah Hagan, Heather A. Pascual, Guoyun Bai, Reza Beheshti Zavareh, Heather R. Coate, Bernard C. Collins, Marjorie Cote, Christine F. Gelin, Kelly L. Damm-Ganamet, Hadi Gholami, Adam R. Huff, Luis Limon, Kevin J. Lum, Puiying A. Mak, Kohki M. Nakafuku, Edmund V. Price, Amy Y. Shih, Mandana Tootoonchi, Nadeem A. Vellore, Jocelyn Wang, Na Wei, Jeannie Ziff, Scott B. Berger, James P. Edwards, Agnes Gardet, Siquan Sun, Jennifer E. Towne, Jennifer D. Venable, Zhicai Shi, Hariharan Venkatesan, Marie-Laure Rives, Sujata Sharma, Brock T. Shireman, Samantha J. Allen
Summary: NKG2D is a key receptor involved in immune response to infections and stress, but its abnormal signaling is associated with inflammatory and autoimmune diseases. In this study, we identified two series of protein-protein interaction inhibitors for NKG2D using a comprehensive small-molecule hit identification strategy. These inhibitors disrupt ligand binding through allosteric modulation of the NKG2D receptor dimer, resulting in improved potency and physicochemical properties. Our findings demonstrate the potential of targeting NKG2D for immune intervention through allosteric modulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Nutrition & Dietetics
Yanyi Huang, Peiyang Zhang, Shuyi Han, Hongxuan He
Summary: The impact of lactoferrin on the intestinal barrier and microflora of H5N1-infected mice was investigated. Lactoferrin consumption alleviated lung and intestinal injury and restored the downregulation of the INAVA gene and intestinal dysfunction caused by H5N1 infection. Lactoferrin also reduced inflammation and reversed changes in the composition of the gut microbiota, increasing the abundance of beneficial bacteria.
Article
Cell Biology
Ramses Ilarraza, Danny Chao, James A. R. Bodman, Alexandra Chesley, Adam Humble, Farzana Shaheen, Gary Eitzen, Paige Lacy
Summary: A key molecule for neutrophil degranulation is Rac2 guanosine triphosphatase. Neutrophils from Rac2 knockout mice (Rac2(-/-)) exhibit impaired primary granule exocytosis in response to cytochalasin B/f-Met-Leu-Phe, while secondary and tertiary granule release is unaffected.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jessica Brubaker, Xueyan Zhang, A. Louis Bourgeois, Clayton Harro, David A. Sack, Subhra Chakraborty
Summary: Recent studies have shown that ETEC infections may lead to growth deficits in children and can cause intestinal and systemic inflammation. The impact of ETEC infection varies with dosage and clinical outcomes, and higher pre-challenge concentrations of certain cytokines are associated with protection from ETEC diarrhea.
Article
Agriculture, Dairy & Animal Science
H. Y. Li, H. G. Yang, H. M. Wu, Q. Q. Yao, Z. Y. Zhang, Q. S. Meng, L. L. Fan, J. Q. Wang, N. Zheng
Summary: The study demonstrated that lactoferrin can modulate LPS-induced inflammation by inhibiting the TLR4-related pathway in pulmonary cell models and mouse models.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Engineering, Biomedical
Marinus A. Wesdorp, Andrea Schwab, Ezgi Irem Bektas, Roberto Narcisi, David Eglin, Martin J. Stoddart, Gerjo J. V. M. Van Osch, Matteo D'Este
Summary: This study presents an in vitro culture model that describes the important functions of neutrophils in tissue repair. The response of neutrophils to different biomaterials was investigated, and differences in neutrophil survival, oxidative burst, myeloperoxidase and neutrophil elastase expression, and cytokine secretion were observed.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Junjia Luan, Lei Wang, Junnan Yang, Xuepeng Li, Jinxiang Wang, Fangchao Cui, Hongbo Mi, Yongxia Xu, Shumin Yi, Jianrong Li
Summary: Novel antioxidant peptides were identified from Pacific saury, and their structures and properties were analyzed. These peptides showed strong antioxidant activity and protective effects against oxidative damage in cells.
Article
Chemistry, Applied
Taotao Dai, David Julian McClements, Ting Hu, Jun Chen, Xuemei He, Chengmei Liu, Jinfeng Sheng, Jian Sun
Summary: This study investigates the interactions between bovine lactoferrin and tannic acid and their effects on foam properties. Hydrophobic forces are found to be the primary forces holding the complexes together. Additionally, the complex exhibits good foam stability but poor foamability, which is closely related to its interactions with polyphenols.
