Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 38, Issue -, Pages 1709-1714Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0381709
Keywords
inportin beta; mitosis; Ran GTPase; spindle microtubule
Categories
Funding
- Fondo Investimenti Ricerca di Base (FIRB) [RBIN04T7MT]
- Progetti di Ricerca di interesse Nazionale (PRIN) [200879X9N9-004]
- Assicurazion Generali and Fondazione Roma Terzo Settore
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Roles of the GTPase Ran in cell life and division rely on a largely conserved mechanism i e Ran s ability to interact with transport vectors Modes of control of downstream factors however are diversified at particular times of the cell cycle Specificity and fine tuning emerge most clearly during mitosis In the present article we focus on the distinction between global mitotic control by the chromosomal Ran gradient and specific spatial and temporal control operated by localized Ran network members at sites of the mitotic apparatus in human cells
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