Article
Biochemistry & Molecular Biology
Neus Pedraza, Ma Ventura Monserrat, Francisco Ferrezuelo, Jordi Torres-Rosell, Neus Colomina, Federico Miguez-Cabello, Javier Picanol Parraga, David Soto, Esperanza Lopez-Merino, Celia Garcia-Vilela, Jose A. Esteban, Joaquim Egea, Eloi Gari
Summary: In this study, Nuclear Cyclin D1 is found to interact with and phosphorylate the α4 subunit of GABA A receptors, increasing the surface levels of α4-containing GABA A receptors and enhancing their response. This molecular link between D1-Cdk4 and GABA A receptors activity highlights a novel role for this G1 cyclin in neuronal signalling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Kenji Muroya, Kenta Ueda, Keiichi Wada, Masakazu Kotoda, Takashi Matsukawa
Summary: The study explores the potential of remimazolam in preventing shivering in hypothermic rabbits. Remimazolam at 1 mg/kg/h significantly lowered the core temperature change during shivering, which may act through the GABA pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
D. Walker Hagan, Sandra M. M. Ferreira, Gustavo J. J. Santos, Edward A. A. Phelps
Summary: GABA, a neurotransmitter produced in the islet, influences the activity of islet cells through multiple receptors and interacts with cellular metabolism. Loss or reduction of GABA in diabetic individuals may contribute to disease pathogenesis and dysfunction of islet cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agronomy
Kazuki Nomura, Satoru Yoshizumi, Fumiyo Ozoe, Yoshihisa Ozoe
Summary: Three cDNAs encoding UNC-49B proteins were cloned from Meloidogyne incognita, which responded to GABA and various antagonists in Xenopus oocytes. The research provides insights for the design of novel nematicides targeting plant-parasitic nematodes.
PEST MANAGEMENT SCIENCE
(2021)
Article
Neurosciences
Anouk Marsman, Anna Lind, Esben Thade Petersen, Mads Andersen, Vincent Oltman Boer
Summary: GABA and GSH play crucial roles in brain functioning and are involved in various neurodegenerative and psychiatric diseases. MRS is a unique non-invasive method to measure these neurometabolites, but motion stabilization is important, especially for specific patient groups. Spectral editing techniques are typically used for unambiguous detection of GABA and GSH, although they increase motion sensitivity.
Article
Food Science & Technology
Yuling Ma, Aixia Wang, Mei Yang, Shanshan Wang, Lili Wang, Sumei Zhou, Christophe Blecker
Summary: The study showed that black mung bean varieties with heat and relative humidity treatment had higher GABA content compared to green varieties. Soaking increased GABA content in mung beans, but a portion of it was distributed in the soaking solution. After cooking, the GABA content in heat and humidity treated mung beans slightly degraded, but remained higher than untreated mung beans.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eun-Jin Kim, Oh-Sang Kwon, Chang-Gi Hur, Marie Merci Nyiramana, Dong-Kun Lee, Seong-Geun Hong, Jaehee Han, Dawon Kang
Summary: This study identified the effect of GABAR agonists on K-2P channel expression and activity in neuroblastic B35 cells. Muscimol, a GABA(A)R agonist, was found to significantly increase TREK-2 expression and activity, potentially reducing cellular excitability in GABAergic neurons through activating the TREK-2 channel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anling Kaplan, Abigail I. I. Nash, Amanda A. H. Freeman, Lauren G. G. Lewicki, David B. B. Rye, Lynn Marie Trotti, Asher L. L. Brandt, Andrew Jenkins
Summary: GABA(A) receptor-positive modulators induce sedation, sleep, and anesthesia, while GABA(A) receptor negative allosteric modulators increase arousal and can induce seizures. By screening 11 compounds known to modulate arousal, we found that they can modulate receptor activation through a GABA-related mechanism, providing new avenues for the treatment of patients with diminished CNS E/I balance.
Review
Nutrition & Dietetics
David J. Nutt, Robin J. Tyacke, Meg Spriggs, Vanessa Jacoby, Alan D. Borthwick, Delia Belelli
Summary: Alcohol consumption is associated with health harms and governments worldwide are trying to reduce them. One approach is to reduce alcohol consumption, leading to the development of non-alcoholic drinks. However, non-alcoholic drinks do not provide the social interaction that alcohol does. Therefore, the alternative approach is to develop functional drinks that mimic the positive effects of alcohol without the harms.
Article
Chemistry, Medicinal
Wei-Hsi Chen, Chuang-Hsin Chiu, Shiou-Shiow Farn, Kai-Hung Cheng, Yuan-Ruei Huang, Shih-Ying Lee, Yao-Ching Fang, Yu-Hua Lin, Kang-Wei Chang
Summary: Studies have found that the neurobiological causes of anxiety disorders may be related to the increase in synaptic concentrations and affinity enhancement of GABA(A) receptors for benzodiazepine ligands. Investigating the metabolites of flumazenil using liquid chromatography-tandem mass spectrometry can provide a complete understanding of its in vivo metabolism. The use of reversed-phase high performance liquid chromatography coupled with electrospray ionization triple-quadrupole tandem mass spectrometry has been used to identify flumazenil and its metabolites in the hepatic matrix.
Review
Psychiatry
Andrew J. Cutler, Gregory W. Mattingly, Vladimir Maletic
Summary: The pathophysiology of major depressive disorder is associated with impaired connectivity in key brain networks, which involves the GABAergic system of neurotransmission. Defects in GABA and neuroactive steroids (NASs) have been observed in adults with depression, and treatment with antidepressants can normalize these levels. There is interest in using NAS GABA(A) receptor positive allosteric modulators (PAMs) as potential treatments for depression, with brexanolone, zuranolone, and PH10 showing promise in clinical development. These NASs may provide novel and effective treatments for patients with major depressive disorder.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Ateequr Rehman, Giulio Di Benedetto, Julia K. Bird, Valentina Dabene, Lisa Vadakumchery, Ali May, Ghislain Schyns, Wilbert Sybesma, Tim N. Mak
Summary: This study focused on the selection and optimization of a bacterial strain with high GABA production for probiotic supplement development. Two biosensors capable of detecting GABA were developed and tested in gut-like conditions. The results provide valuable insights for the development of probiotic supplements and monitoring of GABA in the digestive system.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Chang Sun, Hongtao Zhu, Sarah Clark, Eric Gouaux
Summary: This study reveals the existence of different types of GABA receptors in the brain and the significant role of endogenous neurosteroids in modulating receptor function. These findings contribute to the development of subtype-specific drugs.
Review
Immunology
Yu Shan, Jianan Zhao, Yixin Zheng, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis (RA) is a disabling autoimmune disease with a complex pathological process. The GABAergic system in the nervous system may have immunomodulatory effects and regulate abnormal pain response in RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Oliviero Bruni, Luigi Ferini-Strambi, Elena Giacomoni, Paolo Pellegrino
Summary: Sleep is crucial for physical and emotional wellbeing, but insomnia is a prevalent issue. The interest in using herbal medicines for treating or preventing insomnia has grown. Herbal extracts have been shown to improve sleep quality, potentially through interactions with GABA receptors in the brain.