Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 37, Issue -, Pages 1334-1337Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0371334
Keywords
benzodiazepine; brain; conductance; gamma-aminobutyric acid subtype A receptor (GABA(A) R); hippocampal pyramidal neuron; long-term potentiation (LTP)
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Funding
- Canadian Institutes of Health Research, Ottawa, Ontario, Canada [MOP 79428, MOP 38028]
- Canada Research Chair Award in Anesthesia, Ottawa, Ontario, Canada
- Canadian Institutes of Health Research Canadian Graduate Scholarship, Ottawa, Ontario, Canada
- Natural Sciences and Engineering Graduate Scholarship, Ottawa, Ontario, Canada
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The notion that drug treatments can improve memory performance has moved from the realm of science fiction to that of serious investigation. A popular working hypothesis is that cognition can be improved by altering the balance between excitatory and inhibitory neurotransmission. This review focuses on the unique physiological and pharmacological properties of GABA(A) Rs [GABA (gamma-aminobutyric acid) subtype A receptors] that contain the alpha(5) subunit (alpha(5)-GABA(A) R), as these receptors serve as candidate targets for memory-enhancing drugs.
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