Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 37, Issue -, Pages 971-975Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0370971
Keywords
aneuploidy; chromosome; kinase; kinetochore; mitotic checkpoint; segregation; spindle
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Funding
- Cancer Genomics Centre
- Netherlands Proteomics Centre
- Netherlands Organisation for Scientific Research
- Dutch Cancer Society
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Error-free chromosome segregation during cell division relies on chromosome biorientation and mitotic checkpoint activity. A group of unrelated kinases controls various aspects of both processes. The present short review outlines our current understanding of the roles of these kinases in maintaining chromosomal stability.
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