Article
Cell Biology
Pardis Mohammadzadeh, Mina Roueinfar, Gregory C. Amberg
Summary: This study reveals a novel role for AXL as a modulator of GnRH receptor signaling. Gas6 enhances GnRH-dependent ERK phosphorylation and Egr-1 transcript abundance, and promotes LH beta production and pro-MMP9 protein generation, as well as cell migration.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoli Chen, Jianfei Xu, Wenzhen Bao, Hongda Li, Wenrun Wu, Jiwen Liu, Jingjiang Pi, Brian Tomlinson, Paul Chan, Chengchao Ruan, Qi Zhang, Lin Zhang, Huimin Fan, Edward Morrisey, Zhongmin Liu, Yuzhen Zhang, Li Lin, Jie Liu, Tao Zhuang
Summary: This study investigates the role and mechanism of endothelial cell-specific Foxp1 in neointimal hyperplasia. The results show that Foxp1 deletion in endothelial cells promotes neointimal formation by increasing vascular smooth muscle cell proliferation and migration and reducing endothelial cell proliferation and reendothelialization. On the other hand, Foxp1 overexpression inhibits neointimal formation. It is also found that Foxp1 regulates matrix metalloproteinase-9/cyclin dependent kinase inhibitor 1B signaling pathway to control injury-induced neointimal formation. These findings suggest that targeting EC-Foxp1-matrix metalloproteinase-9/cyclin dependent kinase inhibitor 1B pathway could be a potential therapeutic intervention for restenosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Oncology
Jeong-Mi Kim, Jinny Park, Eun-Mi Noh, Hyun-Kyung Song, Sang Yull Kang, Sung Hoo Jung, Jong-Suk Kim, Byung-Hyun Park, Young-Rae Lee, Hyun Jo Youn
Summary: The study found that BTK inhibitors can attenuate TPA-induced cell invasion and migration in MCF-7 cells, and suppress MMP-9 expression by activating the MAPK or IκB kinase/NF-κB/activator protein-1 pathway.
Article
Biochemistry & Molecular Biology
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou
Summary: Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels. TA has been reported to inhibit MMP-2/- 9 activities, thereby improving tissue remodeling and wound healing. In this study, atomistic modeling was used to explore the mechanisms and structures of TA binding with MMP-2 and MMP-9, revealing the specific binding regions and molecular interactions involved. Understanding the binding mechanism and dynamics of TA with these MMPs provides crucial knowledge on the effects of TA on MMPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Article
Multidisciplinary Sciences
Seung Min Lee, Jin Woo Lee, Inki Kim, Dong-Cheol Woo, Chan-Gi Pack, Young Hoon Sung, In-Jeoung Baek, Chang Hee Jung, Young-Hak Kim, Chang Hoon Ha
Summary: CTRP9 induces a vasoprotective response via the AMPK/HDAC7/p38 MAPK pathway in vascular endothelial cells, promoting angiogenesis and preventing atherosclerosis and myocardial infarction (MI).
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ionut Luchian, Mihaela Moscalu, Ancuta Goriuc, Ludovica Nucci, Monica Tatarciuc, Ioana Martu, Mihai Covasa
Summary: Periodontitis results in destructive effects on periodontium, with increased levels of MMP-9. Periodontal treatment alone or combined with orthodontic treatment can improve clinical parameters and lower MMP-9 levels. The degree of malocclusion affects the treatment's impact on MMP-9 levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Sanu K. Shaji, G. Drishya, Damu Sunilkumar, Nanjan Pandurangan, Geetha B. Kumar, Bipin G. Nair
Summary: Less-studied flavonoid Tamarixetin demonstrated significant dose-dependent inhibition of MMP-9 expression and cancer cell migration and invasion potential, indicating its potential as an anti-cancer agent. The compound also inhibits crucial functions necessary for MMP-9 activation and modulates endogenous regulators of MMP-9 activity, suggesting it could be a template for novel therapeutic applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yihe Wang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies
Summary: Matrix metalloproteinase-9 (MMP9) plays a crucial role in the degradation of extracellular matrix (ECM) proteins. This study demonstrates that MMP9 can be activated by both chloramines and oxidation. The activation of MMP9 and ECM degradation are interdependent processes that may contribute to the progression of diseases.
Review
Biochemistry & Molecular Biology
Zhenshengnan Li, Jia Wei, Bowen Chen, Yaoqi Wang, Shuai Yang, Kehui Wu, Xianying Meng
Summary: Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent proteolytic metalloenzyme that degrades the extracellular matrix (ECM) and has been proven to be elevated in various pathological conditions, including thyroid carcinoma. Its expression level in malignant or metastatic thyroid tumor tissues is higher than in normal or benign tissues, and it correlates closely with clinical features such as lymph node metastasis, TNM stage, and tumor size.
Article
Biochemistry & Molecular Biology
Xiangyang Wu, Yong Wu, Ruijuan Zheng, Fen Tang, Lianhua Qin, Detian Lai, Lu Zhang, Lingming Chen, Bo Yan, Hua Yang, Yang Wang, Feifei Li, Jinyu Zhang, Fei Wang, Lin Wang, Yajuan Cao, Mingtong Ma, Zhonghua Liu, Jianxia Chen, Xiaochen Huang, Jie Wang, Ruiliang Jin, Peng Wang, Qin Sun, Wei Sha, Liangdong Lyu, Pedro Moura-Alves, Anca Dorhoi, Gang Pei, Peng Zhang, Jiayu Chen, Shaorong Gao, Felix Randow, Gucheng Zeng, Chang Chen, Xin-Shan Ye, Stefan H. E. Kaufmann, Haipeng Liu, Baoxue Ge
Summary: Research has shown that mycobacterial arabinogalactan (AG) is recognized by galectin-9, exacerbating mycobacterial infection. Inhibiting the interaction between AG and galectin-9 can potentially alleviate lung pathology caused by infection.
Article
Surgery
Jing Shen, Jian-bo Song, Jun Fan, Zhe Zhang, Zheng-jia Yi, Shuo Bai, Xiao-lin Mu, Yao-bo Yang, Liang Xiao
Summary: This study simulated the process of neointima generation and regression after stent implantation, demonstrating the spatial distribution and dynamic changes of MMP-2, MMP-9, and collagen in ISR. The expression of MMP-2 and MMP-9 decreased and collagen content reached its maximum when ISR occurred, suggesting their potential contribution to ISR.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Clinical Neurology
Yingqiong Xiong, Juanjuan Liu, Yang Xu, Shu Xie, Xinhua Zhou, Shaomin Cheng
Summary: Butylphtalide combined with conventional treatment can decrease MMP-9 levels and increase VEGF levels in patients with stroke, potentially leading to improved prognosis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Chih-Chung Lin, Li-Der Hsiao, Jing-Ming Kuo, Hui-Ching Tseng, Chuen-Mao Yang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Chih-Chung Lin, Wei-Ning Lin, Rou-Ling Cho, Chien-Chung Yang, Yi-Cheng Yeh, Li-Der Hsiao, Hui-Ching Tseng, Chuen-Mao Yang
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Immunology
Chien-Chung Yang, Chuen-Mao Yang
Summary: The pathogenesis of inflammatory diseases is associated with pro-inflammatory factors, ROS, bacterial toxins, and viruses. Oxidative stress plays a role in maintaining cellular redox balance, but excessive ROS production is often induced by excessive stimulation of the mitochondrial electron transport chain and xanthine oxidase, leading to inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Chih-Chung Lin, Chien-Chung Yang, Li-Der Hsiao, Chuen-Mao Yang
Summary: In rat brain astrocytes (RBA-1) cells, CORM-3-induced HO-1 expression is partially mediated through Nox and mitochondria/ROS-dependent PI3K/Akt/mTOR cascade to activate FoxO1 or ROS leading to activation of Nrf2 activity, as demonstrated by transfection with siRNAs or pretreatment with pharmacological inhibitors. Additionally, pretreatment with N-acetyl-L-cysteine, diphenyleneiodonium chloride, apocynin, or rotenone blocked nuclear translocation and promoter binding activity of Nrf2 induced by CORM-3 in RBA-1 cells.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Immunology
Chuen-Mao Yang, Chien-Chung Yang, Li-Der Hsiao, Chia-Ying Yu, Hui-Ching Tseng, Chih-Kai Hsu, Jiro Hasegawa Situmorang
Summary: The study found that TNF-α induces upregulation of COX-2 and PGE(2) through a TNFR1-dependent MitoROS/PKCα/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs. This sheds new light on the mechanisms of TNF-α in cardiac fibrosis and heart failure.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Zih-Yao Yu, Chuen-Mao Yang
Summary: This study demonstrates that rhamnetin attenuates the enhanced expression of MMP-9 induced by BK through inhibiting PKC delta/NOX/ROS/ERK1/2-dependent NF-kappa B activity in RBA-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Chen-Yu Wang, Chien-Chung Yang, Li-Der Hsiao, Chuen-Mao Yang
Summary: This study investigated the expression and regulatory mechanisms of NRROS in astrocytes under the influence of 15d-PGJ(2). The results demonstrated that 15d-PGJ(2) induced NRROS expression through the PI3K/Akt-dependent phosphorylation of FoxO1 and Sp1, as well as the Nrf2 cascade, which effectively suppressed ROS generation and IL-6 expression.
NEUROTOXICITY RESEARCH
(2022)
Article
Cell Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Chih-Kai Hsu, Chia-Yu Hu, Chuen-Mao Yang
Summary: Thrombin triggers the upregulation of COX-2 to promote the secretion of PGE(2), which involves the PAR1/G(q) or G(i/o)/PKCα/MAPK-dependent activation of NF-κB in HTSMCs.
MEDIATORS OF INFLAMMATION
(2022)
Article
Cell Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Hsin-Hui Lin, Chuen-Mao Yang
Summary: This study demonstrated that DDF induced upregulation of HO-1 expression via the EGFR/PKCα/PI3K/Akt-dependent Sp1 pathway in HCFs, leading to attenuation of inflammation responses.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Mei-Hsiu Su, Chuen-Mao Yang
Summary: This study explores the comprehensive mechanisms of how S1P promotes the expression of COX-2 and PGE(2) and induces apoptosis in human cardiac fibroblasts (HCFs) through the activation of MMP9/EGFR-mediated PI3K/Akt/MAPKs-dependent AP-1 activity.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Ching- Chang, Chuen-Mao Yang
Summary: 15d-PGJ(2) induces the expression of HO-1 in bEnd.3 cells through the activation of NOX- and mitochondria-derived ROS-dependent PKC delta/JNK1/2/Sp1/AP-1 signaling pathway, thus protecting against inflammatory responses.
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Li-Der Hsiao, Chen-Yu Wang, Wei-Ning Lin, Ya-Fang Shih, Yi-Wen Chen, Rou-Ling Cho, Hui-Ching Tseng, Chuen-Mao Yang
Summary: This study demonstrates that kaempferol (KPR) can induce HO-1 expression and attenuate inflammation in pulmonary alveolar epithelial cells (HPAEpiCs) through the activation of NOX/ROS/c-Src/Pyk2/PKCα/p38α MAPK and JNK1/2 pathways. The findings suggest that KPR could be a potential strategy for protecting against pulmonary inflammation.
Article
Biochemistry & Molecular Biology
Chuen-Mao Yang, Chien-Chung Yang, Wun-Hsin Hsu, Li-Der Hsiao, Hui-Ching Tseng, Ya-Fang Shih
Summary: Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of cardiac injury, inflammation, and apoptosis. TNF-alpha-induced CCL20 secretion in human cardiac fibroblasts is mediated through a TNFR1-dependent EGFR/p38 MAPK and JNK1/2/FoxO1 or NF-kappa B cascade.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, I-Ta Lee, Yan-Jyun Lin, Wen-Bin Wu, Li-Der Hsiao, Chuen-Mao Yang
Summary: This study confirmed that thrombin induces the production of COX-2 and PGE(2) in human tracheal smooth muscle cells, leading to inflammation in the airways and lungs. The study identified specific signaling pathways involved, including the PKC delta/Pyk2/c-Src/EGFR/PI3K/Akt/AP-1 pathway. Resveratrol was also found to inhibit COX-2 and PGE(2) production by blocking the activation of these signaling molecules, suggesting its potential use in managing airway inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Chien-Chung Yang, Li-Der Hsiao, Mei-Hsiu Su, Chuen-Mao Yang
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)