Editorial Material
Hematology
Thierry Leblanc
Summary: This study uses gene expression profiling to investigate the tumor microenvironment in biopsies from children with classical Hodgkin lymphoma. It compares the findings with an adult cohort and develops a pediatric prognostic model.
Article
Pathology
Sawako Shiraiwa, Yara Yukie Kikuti, Joaquim Carreras, Yusuke Kondo, Ken Ohmachi, Yoshiaki Ogawa, Hiroshi Kawada, Shinji Sato, Yuka Gion, Yasuharu Sato, Naoya Nakamura, Kiyoshi Ando
Summary: Although alterations in 9p24.1 chromosome locus and PD-L1 overexpression have been identified in nodular sclerosis classic Hodgkin lymphoma, it is unclear whether these aberrations occur in CHL and Hodgkin-like lesion (HLL) of methotrexate-associated lymphoproliferative disorder (MTX-CHL and MTX-HLL). This study compared clinicopathological features, genomic status of the 9p24.1 locus, and PD-L1 expression in different types of CHL using immunofluorescence in situ hybridization and immunohistochemistry. The results showed that MTX-CHL has a similar pathogenesis to de novo CHL, while MTX-HLL appears to be a different disease.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Cell Biology
Rajendra Gharbaran, Onyekwere Onwumere, Naomi Codrington, Latchman Somenarain, Stephen Redenti
Summary: The study showed that Prolactin receptor (PRLR) is overexpressed in Hodgkin's lymphoma and may play a role in tumor growth. However, further research is needed to understand the precise role of PRLR in the pathogenesis of Hodgkin's lymphoma.
Review
Oncology
Shaikha Alotaibi, Mehdi Hamadani, Mubarak Al-Mansour, Mahmoud Aljurf
Summary: BIA-ALCL is a rare lymphoproliferative disorder associated with textured implants, with unclear pathogenesis requiring further research. Proper evaluation for diagnosis confirmation is necessary, and treatment approaches vary depending on the disease severity.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2021)
Article
Veterinary Sciences
Hyo-Sung Kim, Han-Jun Kim, Hyun-Jeong Hwang, Sukhun Oh, Sun Hee Do
Summary: A 3-year-old castrated male ferret suspected of lymphoma showed invasive neoplastic cells in mesenteric lymph nodes, liver, and spleen. Immunohistochemistry revealed similarities to human Hodgkin's lymphoma, with significant PD-1 expression suggesting a potential novel diagnostic and prognostic factor for ferrets.
VETERINARNI MEDICINA
(2021)
Article
Pathology
Diede A. G. van Bladel, Michiel van den Brand, Jos Rijntjes, Samhita Pamidimarri Naga, Demi L. C. M. Haacke, Jeroen A. C. W. Luijks, Konnie M. Hebeda, J. Han J. M. van Krieken, Patricia J. T. A. Groenen, Blanca Scheijen
Summary: The clonality analysis plays an important role in diagnosing classic Hodgkin lymphoma, especially in cases with atypical presentation or histology resembling T cell lymphoma and patients with recurrent disease. The development of a novel NGS-based assay has significantly improved the detection of clonal gene rearrangements in cHL cases, particularly in formalin-fixed paraffin-embedded tissue specimens, demonstrating increased sensitivity and performance compared to conventional methods.
Review
Biochemistry & Molecular Biology
Blossom Damania, Shannon C. Kenney, Nancy Raab-Traub
Summary: This review discusses the life cycle of EBV, its impact on host immune responses, and the neoplastic and autoimmune diseases associated with EBV infection.
Article
Education, Special
Tahoora L. Taskeen, Keerthi Sasanka, Dhanraj Ganapathy, Vinay Sivaswamy
Summary: The current study investigated the knowledge and awareness of dental students in Chennai about the treatment protocol of Hodgkin's lymphoma. The results showed that the majority of students had a certain level of understanding about the disease, especially its common symptoms and diagnostic methods. This knowledge can help students in early detection and diagnosis of Hodgkin's lymphoma.
INTERNATIONAL JOURNAL OF EARLY CHILDHOOD SPECIAL EDUCATION
(2022)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)